dc.contributor.author | Senge, Mathias | |
dc.contributor.author | Callaghan, Susan | |
dc.contributor.author | Filatov, Mikhail A. | |
dc.contributor.author | Savoie, Huguette | |
dc.contributor.author | Boyle, Ross W. | |
dc.date.accessioned | 2020-02-04T16:47:55Z | |
dc.date.available | 2020-02-04T16:47:55Z | |
dc.date.issued | 2019 | |
dc.date.submitted | 2019 | en |
dc.identifier.citation | Callaghan, S., Filatov, M.A., Savoie, H., Boyle, R.W. & Senge, M.O., In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy, 2019, Photochemical and Photobiological Sciences, 18, 2 | en |
dc.identifier.other | Y | |
dc.description.abstract | The facile synthesis and in vitro activity of a library of heavy atom-free BODIPY-anthracene, -pyrene dyads (BAD-13–BPyrD-19) and a control (BODIPY 20) are reported. We demonstrate that singlet oxygen produced from dyad triplet states formed from charge-separated states is sufficient to induce cytotoxicity in human breast cancer cells (MDA-MB-468) at micromolar concentrations. The compounds in this series are promising candidates for photodynamic therapy, especially BAD-17 which displays significant photocytotoxicity (15% cell viability) at a concentration of 5 × 10−7 M, with minimal toxicity (89% cell viability) in the absence of light. | en |
dc.format.extent | 495-504 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Photochemical and Photobiological Sciences; | |
dc.relation.ispartofseries | 18; | |
dc.relation.ispartofseries | 2; | |
dc.rights | Y | en |
dc.subject | BODIPY | en |
dc.subject | Heavy atom-free BODIPY-anthracene, -pyrene dyads | en |
dc.subject | Photodynamic therapy | en |
dc.title | In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/sengem | |
dc.identifier.rssinternalid | 206059 | |
dc.identifier.doi | http://dx.doi.org/10.1039/C8PP00402A | |
dc.rights.ecaccessrights | openAccess | |
dc.contributor.sponsor | Science Foundation Ireland | en |
dc.contributor.sponsorGrantNumber | vP 13/IA/1894 | en |
dc.identifier.uri | https://pubs.rsc.org/en/content/articlelanding/2019/PP/C8PP00402A#!divAbstract | |
dc.identifier.uri | http://hdl.handle.net/2262/91438 | |