| dc.contributor.author | Kelly, Daniel | |
| dc.contributor.author | Mahon, Olwyn | |
| dc.contributor.author | McCarthy, Geraldine M. | |
| dc.contributor.author | Dunne, Aisling | |
| dc.date.accessioned | 2020-09-18T12:48:39Z | |
| dc.date.available | 2020-09-18T12:48:39Z | |
| dc.date.issued | 2020 | |
| dc.date.submitted | 2020 | en |
| dc.identifier.citation | Mahon, O.R., Kelly, D.J., McCarthy, G.M. & Dunne, A., Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism, Osteoarthritis and Cartilage, 28, 5, 2020, 603-612 | en |
| dc.identifier.other | Y | |
| dc.description | PUBLISHED | en |
| dc.description.abstract | A number of studies have demonstrated that molecules called ‘alarmins’ or danger-associated molecular patterns (DAMPs), contribute to inflammatory processes in the OA joint. Metabolic reprogramming of immune cells, including macrophages, is emerging as a prominent player in determining immune cell phenotype and function. The aim of this study was to investigate if basic calcium phosphate (BCP) crystals which are OA-associated DAMPs, impact on macrophage phenotype and metabolism. | en |
| dc.format.extent | 603-612 | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Osteoarthritis and Cartilage; | |
| dc.relation.ispartofseries | 28; | |
| dc.relation.ispartofseries | 5; | |
| dc.rights | Y | en |
| dc.subject | ‘alarmins’ or danger-associated molecular patterns (DAMPs) | en |
| dc.subject | Immunometabolism | en |
| dc.subject | Macrophage polarization | en |
| dc.subject | BCP crystals | en |
| dc.subject | Metabolic reprogramming | en |
| dc.title | Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/olmahon | |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/kellyd9 | |
| dc.identifier.rssinternalid | 220268 | |
| dc.identifier.doi | https://doi-org.elib.tcd.ie/10.1016/j.joca.2019.10.010 | |
| dc.rights.ecaccessrights | openAccess | |
| dc.identifier.uri | https://www-sciencedirect-com.elib.tcd.ie/science/article/pii/S1063458419312476?via%3Dihub | |
| dc.identifier.uri | http://hdl.handle.net/2262/93506 | |
