| dc.contributor.author | Bracken, Adrian | en |
| dc.date.accessioned | 2021-03-08T14:30:46Z | |
| dc.date.available | 2021-03-08T14:30:46Z | |
| dc.date.issued | 2020 | en |
| dc.date.submitted | 2020 | en |
| dc.identifier.citation | Glancy, E. and Ciferri, C. and Bracken, A.P., Structural basis for PRC2 engagement with chromatin, Current Opinion in Structural Biology, 67, 2020, 135-144 | en |
| dc.identifier.other | Y | en |
| dc.description | PUBLISHED | en |
| dc.description.abstract | The polycomb repressive complex 2 (PRC2) is a conservedmultiprotein, repressive chromatin complex essential fordevelopment and maintenance of eukaryotic cellular identity.PRC2 comprises a trimeric core of SUZ12, EED and EZH1/2,which together with RBBP4/7 is sufficient to catalyse mono-methylation, di-methylation and tri-methylation of histone H3 atlysine 27 (H3K27me1/2/3). These histone methyltransferaseactivities of PRC2 are deregulated in several human cancers and certain developmental disorders, such as WeaverSyndrome. Core PRC2 associates with several accessoryproteins, which organise to define two main subassemblies,PRC2.1 and PRC2.2. Here we review new biochemical andstructural studies that are providing critical insights into howcore and accessory PRC2 subunits coordinate the faithfuldeposition of H3K27 methylations genome-wide. | en |
| dc.format.extent | 135-144 | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Current Opinion in Structural Biology | en |
| dc.relation.ispartofseries | 67 | en |
| dc.rights | Y | en |
| dc.subject | histone methyltransferaseactivities of PRC2 | en |
| dc.subject | human cancers | en |
| dc.subject | polycomb repressive complex 2 (PRC2) | en |
| dc.subject.lcsh | histone methyltransferaseactivities of PRC2 | en |
| dc.subject.lcsh | human cancers | en |
| dc.subject.lcsh | polycomb repressive complex 2 (PRC2) | en |
| dc.title | Structural basis for PRC2 engagement with chromatin | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/brackea | en |
| dc.identifier.rssinternalid | 224441 | en |
| dc.identifier.doi | http://dx.doi.org/10.1016/j.sbi.2020.10.017 | en |
| dc.rights.ecaccessrights | openAccess | |
| dc.identifier.orcid_id | 0000-0002-1547-9443 | en |
| dc.identifier.uri | http://hdl.handle.net/2262/95582 | |
