Browsing Surgery (Theses and Dissertations) by Title
Now showing items 22-41 of 46
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Investigating the Role of Altered Energy Metabolism in the Therapeutic Response of Rectal Cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2022)Colorectal cancer (CRC) is the 3rd most commonly diagnosed cancer world-wide, accounting for an estimated 10% of all cancers diagnosed annually globally. One in three CRCs occur in the rectum. The standard of care for ... -
Investigation into mitochondrial function and energy metabolism and their connectivity with protumourigenic cellular proceses in Barrett's oesophagus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2016)Contemporary clinical management of Barrett’s oesophagus has highlighted the lack of accurate predictors of neoplastic progression. Currently all Barrett’s patients undergo surveillance, however, only a subset of patients ... -
Investigation of the link between obesity and breast cancer - the role of adipose tissue in the development and propagation of malignancy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Obesity and the metabolic syndrome are emerging risk factors for breast cancer. They are associated with increased incidence, an increased recurrence rate and a poorer prognosis. Despite this epidemiological evidence to ... -
Investigation of the molecular mechanisms underlying radioresistance in oesophageal cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2011)The current standard of care for oesophageal cancer in Ireland involves neoadjuvant chemoradiation therapy (CRT) followed by surgery. Despite advances in treatment, resistance to neoadjuvant CRT remains a significant ... -
Investigation of the role of the complement system in the radioresistance of rectal cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Colorectal cancer (CRC) is the third most common cancer globally, accounting for approximately 10% of all cancer diagnoses. A third of CRCs occur in the rectum. The majority of CRCs are diagnosed at advanced stages and ... -
Local and systemic inflammation in oesophageal disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Background: Reflux-induced injury and oxidative stress result in oesophageal inflammation and the potential for progression to intestinal metaplasia and adenocarcinoma. Proton-pump inhibitors represent the standard medical ... -
Malnutrition, deficiency, and nutritional practice in patients with acute and chronic pancreatitis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)Pancreatitis is an inflammatory disease of the pancreas and it may occur in either acute or chronic form, the former being life-threatening in its most severe form, and the latter being a progressive, irreversible disease ... -
Mechanisms linking obesity, genomic instability and the radioresponse in oesophageal adenocarcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)The increasing incidence of oesophageal adenocarcinoma (OAC) parallels the rapidly rising incidence of obesity. OAC is an exemplar model of obesity-associated cancer, with an increasing focus on the role of visceral adipose ... -
Mitochondrial dysfunction during disease progression in Barrett's oesophagus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)Barrett’s oesophagus is the leading risk factor for oesophageal adenocarcinoma. However, it is difficult to identify patients at risk of disease progression. Mitochondria are highly susceptible to mutations due to high ... -
Molecular analysis of cell proliferation and apoptosis in oesophageal adenocarcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2002)Cancer of the oesophagus is a particularly virulent gastrointestinal malignancy with poor prognosis. Replacement of the nomial squamous epithelium of the oesophagus with columnar epithelium (Barrett’s oesophagus) as a ... -
Molecular and radiological prediction of response to neo-adjuvant chemoradiation in patients with oesophageal cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2009)The initial phase of the project’s laboratory component involved optimising techniques that would become necessary when analysing fresh oesophageal tissue. There are a number of commercially available techniques for tissue ... -
Molecular interactions in obesity and cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)The incidence of overweight and obesity has reached pandemic proportions in modern society, affecting two thirds of the US and over half of the European population. Obesity is associated with increased morbidity and mortality ... -
Nutritional studies in upper gastrointestinal cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2008)Carcinoma of the oesophagus, gastro-oesophageal junction and stomach represent aggressive diseases with a poor prognosis even in patients undergoing curative resection. Where squamous cell histology once predominated, the ... -
Obesity and cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2011)Cancer rates are increasing with predictions of incidence rates doubling between 2000 and 2020. Although several factors are contributory, the rising incidence of overweight and obesity is currently thought to be fuelling ... -
Oesophageal cancer : association with visceral obesity, inflammation and optimisation of postoperative outcomes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2013)The incidence of oesophageal cancer is rising in the developed world and has paralleled the rising prevalence of obesity. This is an aggressive malignancy with poor overall survival rates. Thus there is an impetus to ... -
Oesophageal inflammation and tumourigenesis - inherited variation in an Irish population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Cancer is a major medical challenge of this era and early diagnosis of cancer is critical to curative therapy. The search for biomarkers that may indicate the risk or presence of cancer is ongoing in thousands of laboratories ... -
Pelvic floor dysfunction : its assessment by MRI and strength duration test and its response to biofeedback
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2006)The component features of pelvic floor dysfunction (PFD) are interrelated but the development of a unified strategy to investigate and treat these problems has been slow; this has invariably affected the outcome of available ... -
Predictors of response of rectal cancer to neoadjuvant radiochemotherapy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2007)Rectal cancers staged as cT3/T4 +/- node positive routinely receive neoadjuvant radiochemotherapy (RCT) followed by total mesorectal excision (TME). By this approach tumours can be both downstaged and downsized resulting ... -
Systemic inflammation after cardiac surgery
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2008)Genetically determined inter-individual variation in cytokine production, influences outcome in patients with systemic inflammation and severe sepsis. However outcome in patients with sepsis is also dependant on the presence ... -
The effect of major surgery on systemic and splanchnic immune function : examining the two-hit and gut hypotheses of the systemic inflammatory response syndrome
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2006)The systemic inflammatory response syndrome (SIRS), sepsis and multiple organ dysfunction syndrome (MODS) are recognized sequelae of complex major surgery and underlie significant morbidity and mortality. The systemic ...