Browsing Surgery (Theses and Dissertations) by Title
Now showing items 7-26 of 46
-
End-Of-Life Decision Making A Novel Entrustable Professional Activity?
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2022)Introduction: Making tough decisions about End-Of-Life situations and palliative care in acute surgical scenarios is a non-technical skill surgeons have to master over a number of years of experience. Data suggests that ... -
Enhancing treatment response to neo-adjuvant radiation therapy in oesophageal cancer using novel dual action drugs targeting tumour energy metabolism and angiogenesis
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2019)Oesophageal cancer is an aggressive malignancy associated with a poor 5-year survival of <20%, accounting for over 400,000 deaths each year. The current standard of care for oesophageal adenocarcinoma (OAC) ... -
The Epidemiological, Clinical and Genetic Aspects of Chronic Pancreatitis in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2018)Abstract: The epidemiological, clinical and genetic aspects of chronic pancreatitis in Ireland - Hazel Maria Ní Chonchubhair. Introduction: Chronic pancreatitis is a progressive, inflammatory, malabsorptive disease of the ... -
Examining the Radiation-induced Bystander Effect (RIBE) and its Effect on Metabolism and Inflammation in Gastrointestinal Cancers
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2021)Radiation therapy is a mainstay of treatment for cancer. However, resistance to therapy remains a major clinical problem in rectal and oesophageal cancer, with at best only 27-30% of patients achieving a complete pathological ... -
Expanding the role of positron emission tomography-computed tomography and its utility in the management of oesophageal cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2018)Purpose: 18F-fluorodeoxyglucose positron emission tomography and computed tomography (18F-FDG PET-CT) is an established diagnostic tool in the management of oesophageal cancer. The role of 18F-FDG PET-CT in assessing tumour ... -
Experimental reinforcement of the vertebral endplate : a biomechanical study on prevention of intervertebral cage subsidence
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2007) -
Exploring the influence of obesity, fatty acids, and current treatment modalities on the immune-metabolic profiles of adipose tissue in oesophageal cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Oesophageal adenocarcinoma (OAC) is a poor prognosis cancer with limited response rates to current standard of care treatments including chemotherapy and chemoradiotherapy. OAC has one of the strongest associations with ... -
Extending the limits of cardiovascular disease risk estimation : the roles of HDL cholesterol, resting heart rate and advancing years
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Background: Atherosclerotic cardiovascular diseases (CVD) including coronary heart disease, stroke and peripheral vascular disease are the commonest causes of death Worldwide. The underlying atherosclerosis starts early ... -
Gastro-oesophageal reflux disease : studies in physiology and innovations in surgical management
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2007)The work detailed in this thesis combined studies in surgical audit with assessment of outcomes relating to dysmotility, evaluated an innovative approach to quality assurance in surgery, explored new understandings of ... -
Gene expression profiling in patients with severe sepsis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)The human response to infection ranges from mild illness which is relatively well tolerated to a severe, potentially life-threatening syndrome termed severe sepsis. This thesis explored this response in patients hospitalised ... -
Harnessing natural killer cell-mediated immune responses in obesity-associated cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Oesophagogastric adenocarcinomas (OAC) encompass a group of inflammation-driven and obesity-associated cancers. Poor 5-year survival rates of less than 20% and treatment response rates of less than 30% place these as poor ... -
In vitro assessment of primary human chondrocyte viability following treatment with intra-articular contrast agents and local anaesthetic
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2021)Title In vitro assessment of primary human chondrocyte viability following treatment with intra-articular contrast agents and local anaesthetic. Introduction Magnetic resonance (MR) and computed tomography (CT) direct ... -
Integrative multi-omic analytics for the early detection of pancreatic cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Pancreatic cancer (PC) has the lowest 5-year survival rate of any cancer, at just 12% in 2023. The poor survival rates observed in this cancer are the result of an accumulation of shortcomings and gaps in many aspects of ... -
Investigating the applicability of immune checkpoint blockade in upper gastrointestinal cancers
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2022)Oesophagogastric junctional adenocarcinoma (OGJ) is an aggressive malignancy with a high propensity to metastasise. Response rates to first-line chemo(radio)therapy regimens remain poor therefore, better treatment options ... -
Investigating the impact of body composition and nutritional intervention strategies in pancreatic cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2020)Introduction: Pancreatic adenocarcinoma (PDAC), while often described a rare or neglected cancer, is the fourth cause of cancer-related mortality in the US and Europe. Unintentional weight loss is a prominent feature of ... -
Investigating the Role of Altered Energy Metabolism in the Therapeutic Response of Rectal Cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2022)Colorectal cancer (CRC) is the 3rd most commonly diagnosed cancer world-wide, accounting for an estimated 10% of all cancers diagnosed annually globally. One in three CRCs occur in the rectum. The standard of care for ... -
Investigation into mitochondrial function and energy metabolism and their connectivity with protumourigenic cellular proceses in Barrett's oesophagus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2016)Contemporary clinical management of Barrett’s oesophagus has highlighted the lack of accurate predictors of neoplastic progression. Currently all Barrett’s patients undergo surveillance, however, only a subset of patients ... -
Investigation of the link between obesity and breast cancer - the role of adipose tissue in the development and propagation of malignancy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Obesity and the metabolic syndrome are emerging risk factors for breast cancer. They are associated with increased incidence, an increased recurrence rate and a poorer prognosis. Despite this epidemiological evidence to ... -
Investigation of the molecular mechanisms underlying radioresistance in oesophageal cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2011)The current standard of care for oesophageal cancer in Ireland involves neoadjuvant chemoradiation therapy (CRT) followed by surgery. Despite advances in treatment, resistance to neoadjuvant CRT remains a significant ... -
Investigation of the role of the complement system in the radioresistance of rectal cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Colorectal cancer (CRC) is the third most common cancer globally, accounting for approximately 10% of all cancer diagnoses. A third of CRCs occur in the rectum. The majority of CRCs are diagnosed at advanced stages and ...