Browsing Surgery (Theses and Dissertations) by Subject "cancer"
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Targeting DNA Damage Repair Deficiency in Pancreatic Cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, School of Medicine, 2024)Pancreatic ductal adenocarcinoma is a lethal disease with a 5-year survival of <12%. Approximately 5-10% of the patients have BRCA1/2 mutations which cause homologous recombination (HR) deficiency and sensitise to cisplatin ...