Browsing Surgery (Theses and Dissertations) by Subject "chemotherapy"

Now showing items 1-2 of 2

    • Investigating the applicability of immune checkpoint blockade in upper gastrointestinal cancers 

      Davern, Maria (Trinity College Dublin. School of Medicine. Discipline of Surgery, 2022)
      Oesophagogastric junctional adenocarcinoma (OGJ) is an aggressive malignancy with a high propensity to metastasise. Response rates to first-line chemo(radio)therapy regimens remain poor therefore, better treatment options ...

    • Targeting DNA Damage Repair Deficiency in Pancreatic Cancer 

      Stoof, Jojanneke (Trinity College Dublin. School of Medicine. Discipline of Surgery, School of Medicine, 2024)
      Pancreatic ductal adenocarcinoma is a lethal disease with a 5-year survival of <12%. Approximately 5-10% of the patients have BRCA1/2 mutations which cause homologous recombination (HR) deficiency and sensitise to cisplatin ...