Surgery (Scholarly Publications): Recent submissions
Now showing items 81-100 of 131
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Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma.
(2014)Background Visceral obesity has a strong association with both the incidence and mortality of esophageal adenocarcinoma (EAC). Alterations in mitochondrial function and energy metabolism is an emerging hallmark of cancer, ... -
Presentation and management of gastrointestinal stromal tumours.
(2013)Duodenal gastrointestinal stromal tumors (GIST) have been described primarily in isolated case reports. In order to learn more about duodenal GIST, a retrospective review of patients with GIST managed at a single institution ... -
Severe epigastric pain following a birthday party.
(2013)Epigastric pain is a very common symptom which can be caused by a wide range of clinical conditions. A 28 year old male presented to our clinic with new onset severe epigastric pain. As part of the routine work up for pain ... -
Heritability of subcortical volumetric traits in mesial temporal lobe epilepsy.
(2013)OBJECTIVES: We aimed to 1) determine if subcortical volume deficits are common to mesial temporal lobe epilepsy (MTLE) patients and their unaffected siblings 2) assess the suitability of subcortical volumetric traits ... -
Diffuse oesophageal leiomyomatosis.
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Expression of neuroepithelial transforming gene 1 is enhanced in oesophageal cancer and mediates an invasive tumour cell phenotype.
(2013)Introduction Neuroepithelial Transforming Gene 1 (NET1) is a well characterised oncoprotein and a proven marker of an aggressive phenotype in a number of cancers, including gastric adenocarcinoma. We aimed to investigate ... -
Determinants of short- and long-term survival from colorectal cancer in very elderly patients
(2014)PURPOSE: Over 5100 colorectal cancers (CRCs) are diagnosed in the United Kingdom in 85years and older age group per year but little is known of cancer progression in this group. We assessed clinical, pathological and ... -
Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma
(2014)Neoadjuvant chemoradiation therapy (CRT) is increasingly the standard of care for locally advanced oesophageal cancer. A complete pathological response to CRT is associated with a favourable outcome. Radiation therapy is ... -
A prospective investigation of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2 gene carriers
(2013)Background Breast cancer is the most common female cancer worldwide. The lifetime risk of a woman being diagnosed with breast cancer is approximately 12.5%. For women who carry the deleterious mutation in either of the ... -
Decreased Mitochondrial DNA Mutagenesis in Human Colorectal Cancer
(2012)Genome instability is regarded as a hallmark of cancer. Human tumors frequently carry clonally expanded mutations in their mitochondrial DNA (mtDNA), some of which may drive cancer progression and metastasis. The high ... -
Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a -/- mutants
(2011)Genetic alterations in human topoisomerase II alpha (TOP2A) are linked to cancer susceptibility. TOP2A decatenates chromosomes and thus is necessary for multiple aspects of cell division including DNA replication, chromosome ... -
Heat shock protein derived from a non-autologous tumour can be used as an anti-tumour vaccine.
(2003)Antigenic cross-reactivity between certain tumours has allowed the development of more widely applicable, major histocompatibility complex-disparate (allogeneic) whole-cell vaccines. This principle should also allow heat ... -
Tumour Tissue Microenvironment Can Inhibit Dendritic Cell Maturation in Colorectal Cancer
(2011)Inflammatory mediators in the tumour microenvironment promote tumour growth, vascular development and enable evasion of anti-tumour immune responses, by disabling infiltrating dendritic cells. However, the constituents ... -
Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment.
(2014)The immune system has a key role to play in controlling cancer initiation and progression. T cell activation, which is central to anti-tumor immune responses, coincides with changes in cellular metabolism. Naïve T cells ...
