Chemistry (Theses and Dissertations): Recent submissions
Now showing items 201-220 of 435
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The design, synthesis and application of (thio)urea-based organocatalysts for a range of C-C bond transformations
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)The identification and development of small chiral organic molecules capable of mimicking the hydrogen-bonding capabilities of enzymes is the main thrust of this thesis concerning the design and application of new (thio)urea ... -
Synthetic and spectroscopic studies of novel nonplanar tetrapyrrolic macrocycles
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)The aim of this work was to develop a new synthetic route for the synthesis of hydroporphyrins and to investigate their photophysical properties. A second aim was to investigate the effect of protonation on the conformation ... -
Synthesis of nitropyrimidines as inactivators of 0-6-Methylguanine-DNA Methyltransferase
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)The cytotoxic effects of the chemotherapeutic N-(2-chloroethyl)-N-nitrosoureas (e.g. BCNU, CCNU, fotemustine) and the related methylating agents (e.g. DTIC, procarbazine, temozolomide) are primarily a consequence of their ... -
Redox cationic polymerisation
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)The aim of this work is the development of an initiation chemistry that allows preparation of storage stable single-component epoxy compositions, which polymerize when contacted with metallic substrates, at ambient ... -
Synthetic investigations towards the preparation of novel tetracycline antibiotics
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)This research initially concerned itself with the synthesis of a dimeric compound of tetracycline antibiotics linked by a flexible tether. Tetracycline antibiotics have been in use since their discovery in the 1940s but ... -
Diquaternerised and Ru(11) based polypyridyl conjugates as biological probes and phototherapeutic agents
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)This Thesis entitled 'Diquaternerised and Ru(ll) Based Polypyridyl Conjugates as Biological Probes and Phototherapeutic Agents' is divided into 8 Chapters. Chapter 1, the introduction, gives a brief introduction to the ... -
Novel colorimetric and fluorescent sensors for anions
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)This thesis, entitled "Novel Colorimetric and Fluorescent Sensors for Anions" consists of six Chapters. Chapter 1 provides an introduction into the field of anion sensing using fluorescent and colorimetric sensors, within ... -
Synthesis and biological evaluation of diaromatic guanidinium-like derivatives as protein kinase inhibitors for the treatment of cancer
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)The aim of a chemotherapeutic drug is to specifically target a biomolecule involved in the development of cancer whilst not affecting healthy tissues. Unfortunately, this is a difficult task due to the complexity of the ... -
Single-walled carbon nanotubes and photo switchable spiropyrans : novel multifunctional platforms for sensing and biological applications
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)Over the last years the applications of chemically modified carbon nanotubes have considerably expanded and progressed in both material and biomedical science. A vast number of SWNTs based materials have been rationally ... -
Development of new silica and magnetic-luminescent silica nanostructured materials
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)The main aim of this project is to develop a series of nanocomposite materials based on silica and magnetic-luminescent silica nanoparticles. The work involves the synthesis and characterisation of silica nanoparticles, ... -
Synthesis and biological evaluation of glycophorphyrins for use as photodynamic therapy agents
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)Photodynamic therapy (PDT) is a light activated anti-cancer treatment. Reagents for PDT have advanced dramatically since the earliest porphyrin based oligomers. Ultimately the focus is on improving the efficacy of these ... -
Novel biomimetic organocatalysts and asymmetric formal cycloaddition reactions using enolisable anhydrides as nucleophiles
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)The synthesis of a biomimetic organocatalyst bearing functional groups mimicking the active residues in the active site of the oxidoreductase enzyme non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (GAPN) has ... -
A synthetic development of tetrazines as ligands in Group 8 coordination complexes
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)Chapter 1 describes the synthesis and characterization of a number of novel pyridazinecentred ligands prepared from substituted tetrazines. The use of these compounds as precursors for planar nitrogen containing graphite-type ... -
Synthesis, photophysical and DNA binding studies of novel pyridinium based 1 ,8-naphthalimide derivatives
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)This thesis entitled "Synthesis, Photophysical and DNA Binding Studies of Novel Pyridinium Based 1,8-Naphthalimide Derivatives" is divided into six chapters. Chapter 1 is the introductory chapter, which provides a brief ... -
Stannyl porphyrins, ferrocenyl porphyrins and nonplanar porphyrins : synthesis and photophysical properties
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)The aim of this work was to synthesis the tin porphyrins, ferrocene porphyrins and nonplanar multiporphyrins arrays. The next step was to investigate their photophysical properties. -
Thio(Urea) derivatives : from anion sensing and recognition towards supramolecular assemblies
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)This thesis entitled (Thio)Urea Derivatives - From Anion Sensing and Recognition to Supramolecular Assemblies consists of seven chapters. Chapter 1 provides an introduction to the field of anion sensing using various organic ... -
Mechanical properties of one-dimensional nano-systems
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)The measurement of mechanical properties of nano-scale materials is paramount for their safe and efficient incorporation into devices. Techniques to perform these measurements are reviewed here with a particular interest ... -
Nanoelectromechanical relays for low power integrated circuits
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2019)The semiconductor industry roadmap was described by Intel cofounder, Gordon Moore, fifty years ago when he predicted that the number of transistor devices on a silicon integrated circuit would double with every new generation ... -
Electrochemical Studies of the Oxygen Evolution Reaction at Mn, Ni/Co Mixed Oxide Electrodes in Aqueous Alkaline Solution
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2019)There has been an abundance of publications over the last twenty years on electrode materials proposed to be suitable catalysts for the oxygen evolution reaction (OER) in alkaline solutions. Although it is widely accepted ... -
Synthesis of Transition Metal Dichalcogenides from Solid-Phase Precursors
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2019)Interest in telluride tranisition metal dichalcogenides (TMDs) has until very recently, lagged far behind that of more common TMDs such as MoS2. There are a number of potential reasons for this, such as these materials not ...
