Chemistry (Theses and Dissertations): Recent submissions
Now showing items 181-200 of 435
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Synthesis of some homochiral-2aminopyridine N-oxides as potential chiral hypernucleophilic acylation catalysts
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)This thesis is concerned with the study and attempted synthesis of an array of homochiral pyridines and their N-oxides and their ultimate use as potential hypernucleophilic promoters of the acylation of a variety of racemic ... -
Synthesis and photophysical investigation of novel supramolecular lanthanide luminescent architectures
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)This thesis is entitled "Synthesis and photophysical investigations of novel supramolecular architectures" and is composed of five chapters. In the first chapter the photopysical and chemical properties of the lanthanide ... -
Synthesis, functionalization and applications of silver nanoparticles
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)The aim of the work described in this thesis is to investigate various different methods for synthesis, functionalization and surface-enhanced Raman spectroscopy applications of silver nanoparticles. -
Novel system development for combined scanning tunneling microscopy & surface stress measurements to investigate the origins of surface forces
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)The oxidation of the silicon surface has been widely studied due to its vast scientific and technological importance. However, despite extensive work on the topic the exact details of the oxidation reaction still remain a ... -
Nanoparticle & luminescent ruthenium oligonucleotide conjugates
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)The field of plasmonies is a rapidly growing area of research and holds much promise for the improvement of diagnostics. The work in this thesis outlines the advances that have been made to assemble the components needed ... -
The design, synthesis and evaluation of aryl guanidinium derivatives as α2 adrenoceptor antagonists for the treatment of depression
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)Depression is among the leading causes of illness worldwide and is predicted to be the single largest contributor by 2020. Antidepressants are the most effective treatment but current drugs have slow onset of effects and ... -
Computational analysis of the defect chemistry of ceria
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)One of the most important issues facing humanity is the impending threat of climate change. In order to combat the rising levels of atmospheric pollutants, many new technologies are being developed to alleviate the strain ... -
The development of novel organocatalysts for asymmetric methylene transfer in the Corey-Chaykovsky reaction
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)To date, the enantioselective preparation of terminal three-membered heterocycles via the Corey-Chaykovsky (CC) reaction has been characterised by unsatisfactory enantioselectivities. In the benchmark literature report ... -
New families of minor groove binders : synthesis, biophysical and biochemical evaluation and their role in apoptosis
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)There is an active field in the design and synthesis of DNA targeting molecules as potential anticancer agents. Although a number of successful drug treatments against a variety of cancers are in clinical use, many of these ... -
Strategies towards the synthesis of linear tetrapyrroles and the reactions of substituted pyrroles with sulfuryl chloride
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)The research undertaken in the present study describes the synthesis of bilins from easily obtainable starting materials using robust methods and the unusual reaction of SO2CI2 with tetrasubstituted pyrroles. -
Photoluminescence properties of open and closed uranium compounds in non-aqueous media
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)Luminescence spectroscopy has been successfully applied to elucidate the photophysical properties of a family of uranium halides and pseudohalides, in two oxidation states (U IV and U VI) in non-aqueous media. The first ... -
Quantum dots and quantum dot based polymer composites
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)The main aim of this thesis is to develop a range of new nanomaterials and composite materials based on fluorescent semiconducting nanoparticles (quantum dots). The work involves the synthesis and characterisation of various ... -
Synthesis, characterisation and applications of chiral nanoparticles
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)The main aim of this thesis is to develop and investigate novel chiral nanomaterials, as well as explore potential applications that would exploit the chirality. Chapter 1 details a general introduction to nanotechnology, ... -
The electronic structure of transparent conducting oxides
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)Transparent conducting oxides (TCOs) are a unique class of materials which combine the normally mutually exclusive properties of transparency and conduction. Although their discovery dates back over a century and despite ... -
Research and development in the synthesis of cyanoacrylates
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)This dissertation is aimed at developing a new synthetic chemistry suitable for the selective production of highly reactive, high yield and purified electron deficient enes in bulk quantities. -
Quanutm dot metal nanoparticle based composites for biomedical applications
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)The main aim of this project is to develop a range of nanocomposite materials based on gold and silver nanostructures and semiconductor nanoparticles, or quantum dots (QDs). The work involves the synthesis, functionalisation ... -
Investigation into the interactions of quantum dot based systems
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)The main aim of this thesis is to develop a range of new nanomaterials and composite materials based on fluorescent semiconducting nanoparticles (quantum dots). The work involves the synthesis and characterisation of various ... -
Biological investigations of novel 1,8-naphthalimide compounds and the design and synthesis of pyridine based polyamides
(Trinity College (Dublin, Ireland). School of Chemistry, 2009)This thesis entitled "Biological Investigations of Novel 1,8-Naphthalimide Compounds and the Design and Synthesis of Pyridine Polyamides" is divided into six chapters. Chapter 1, the introduction focuses on the basic ... -
New methodologies for catalysis and combinatorial chemistry
(Trinity College (Dublin, Ireland). School of Chemistry, 2013)The enantioselective synthesis of chiral molecules, such as those required by the pharmaceutical industry, is one of the most important tasks in chemistry. Asymmetric catalysis is an attractive way to synthesise enantiopure ... -
Design, synthesis and pharmacological evaluation of novel heterocyclic guanidine derivatives as alpha₂-adrenoceptor antagonists for the treatment of depression
(Trinity College (Dublin, Ireland). School of Chemistry, 2012)Messages travel through the brain and nervous system in two ways, the first is in the form of an electrical impulse, called an action potential, which travels along a cell called a neuron. The second is via a chemical ...
