Chemistry (Theses and Dissertations): Recent submissions
Now showing items 61-80 of 435
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Development of a Scaleable Breath-figure Type Polymer Thin Film Patterning Process via Controlled Vapour Swelling of Thin Films
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)Efficient production of microporous polymeric films can be rapidly synthesised by changing the thermodynamics of a polymeric solution in a humid atmosphere. This conventional method, known as ?breath figure? (BF), involves ... -
The Design of Ruthenium and Iridium Triplet Photosensitisers
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)This thesis describes compounds designed to harness the energies of photon-induced transitions between electronic energy levels. Applications that involve such transitions include but are not limited to photodynamic therapy, ... -
High-Throughput Computational Investigation of Homogeneous and Heterogeneous Water Splitting Catalysts
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)Understanding the sources of activity and stability in oxygen evolution reaction catalysts remains an open challenge. This thesis attempts to understand these factors by studying many catalysts for both homogeneous OER to ... -
Development of novel porous materials via polymer self-assembly and phase separation
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)Polymer self-assembly is an ever-growing field that is attracting interest from a diverse range of research topics, which include the production of functional devices and membranes for electronic, optical and energy ... -
Synthesis and analysis of Nile Red functionalised Ru(II) and Ir(III) photosensitisers
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)Nile Red (9-(diethylamino)-5H-benzo[a]phenoxazin-5-one) is a common organic dye that exhibits strong absorption of visible light, and is highly fluorescent. Despite these properties, examples of transition metal complexes ... -
Design, synthesis, and biochemical evaluation of guanidine-based derivatives targeting protein kinases
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Kinases are some of the most intensively pursued classes of drug targets with approximately 243 distinct kinase inhibitors making it to human trials and most of these compounds are being investigated for the treatment of ... -
Synthetic Approaches to Metal-Organic Frameworks and Coordination Cages Incorporating Heterocycle-Based Linkers
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)This thesis, entitled Synthetic Approaches to Metal-Organic Frameworks and Coordination Cages Incorporating Heterocycle-Based Linkers, focuses on the synthesis of metal-organic frameworks (MOFs) and coordination cages using ... -
On the Synthesis and Utilization of geminal-Dimethyl Hydroporphyrins and Tetraphenylethylenes in Photodynamic Therapy
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Chapter 1 introduces the main concepts of this thesis: photodynamic therapy (PDT), chlorins and photosensitizer arrays. In the case of PDT multiple topics are discussed, namely, the qualities of an ideal photosensitizer, ... -
Unravelling the Pivotal Role of Atropisomerism for Cellular Internalization
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Atropisomerism presents an intriguing, often neglected, source of varied biological activity in drug development. For a stable atropisomeric drug mixture, assessment of individual atropisomers may reveal an individual ... -
Development of modified nucleosides for targeting the DNA repair enzyme SNM1A
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Certain cancers exhibit upregulation of DNA interstrand crosslink repair pathways, which contributes to resistance to crosslinking chemotherapy drugs and poor prognoses. Inhibition of enzymes implicated in interstrand ... -
Triplet Photosensitisers: From Molecular Designto Light-Driven Applications
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Transition metal complexes, particularly Ir(III) and Ru(II), exhibit attractive photophysical properties and have long been the subject of scientific research owing to their use in various light-driven applications. This ... -
Selective Deposition: Fabrication of Coherent Nano-Dimensioned Metal Oxide Films by Monolayer Polymer Brush Template Assisted Inclusion
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022) -
Synthesis and Physicochemical Characterisation of Pristine Metal-Organic Frameworks, Thin-Films and Derived Materials
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Metal-organic frameworks (MOFs) are hybrid coordination materials, characterised by their high surface area and internal porosity, formed from organic linkers and inorganic nodes. Additionally, MOFs have the ability to act ... -
Porphyrin Atropisomerism - a New Twist in Molecular Recognition and Supramolecular Architectures
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)The unifying theme of the work reported in this thesis is the exploitation of the flexibility of the porphyrin macrocycle using sterically demanding units to construct supramolecular receptors for selective guest encapsulations. ... -
Covalently cross-linked tetrafunctionalized m-THPC chitosan hydrogels as drug delivery platforms
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Photodynamic therapy (PDT) is an anti-cancer treatment method which uses the combined effect of a photosensitizing drug, light, and oxygen to cause selective damage to target tissue. The second generation photosensitizer ... -
Development of Supramolecular Coordination Materials Using Naphthalimide and 2,6-bis(triazol-4-yl)pyridine Motifs
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Structural coordination chemistry can be ultilised to develop functional supramolecular materials such as coordination polymers, soft materials, and metal organic frameworks. By applying the principles of self-assembly an ... -
Computational Modelling of Perovskite-based Materials for Solid Oxide Fuel Cell Applications
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)The development and use of clean and renewable modes of power generation is essential to address the increasing environmental and health concerns associated with fossil fuel consumption. Solid oxide fuel cells (SOFCs) ... -
Development and Studies of New Magnetic Core@Shell Nanostructures
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)In this work, the synthesis of various magnetic nanoparticles such as magnetite, manganese ferrite, cobalt ferrite and copper ferrite is explored using different synthetic protocols. The produced nanomaterials are characterised ... -
Development of 2D Nanomaterials Based Membranes for Nanofiltration Applications
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)The main aim of this work was to develop new membranes based on 2D nanomaterials, such as boron nitride (BN) and molybdenum disulphide (MoS2) for potential nanofiltration applications. The exfoliation and membrane preparation ... -
Selective Mineralisation by Hydrothermal Methods
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)The use of hydrothermal synthesis has led to the control of the size and shape of various materials of inorganic nature. It has also been highlighted as a green, cheap, and reliable synthetic method, by using water in ...
