Browsing Physiology (Scholarly Publications) by Sponsor "Health Research Board (HRB)"
Now showing items 1-8 of 8
-
Adenosine A(2A) receptors control neuroinflammation and consequent hippocampal neuronal dysfunction.
(2011)The blockade of adenosine A2A receptors (A2AR) affords a robust neuroprotection in different noxious brain conditions. However, the mechanisms underlying this general neuroprotection are unknown. One possible mechanism ... -
Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain
(2011)Abstract: Background: Microglial function is modulated by several factors reflecting the numerous receptors expressed on the cell surface, however endogenous factors which contribute to the age-related increase in microglial ... -
Immunology meets neuroscience - opportunities for immune intervention in neurodegenerative diseases
(2011)Neuroinflammatory changes are characteristic of many, if not all, neurodegenerative diseases but the extent to which the immune system is involved in the pathogenesis of these diseases is unclear. The findings of several ... -
Long-term potentiation is impaired in CD200-deficient mice: a role for Toll-like receptor activation.
(2011)The membrane glycoprotein CD200 is expressed on several cell types including neurons whereas expression of its receptor, CD200R, is restricted principally to cells of the myeloid lineage, including microglia. The interaction ... -
Neuroinflammatory changes negatively impact on LTP: a focus on IL-1β
(2015)In recent years it has become clear that neuroinflammatory changes develop in the brain with age and that similar, though more profound changes, occur in neurodegenerative conditions and in animal models of neurodegeneration. ... -
Priming exercise accelerates pulmonary oxygen uptake kinetics during "work-to-work" cycle exercise in middle-aged individuals with type 2 diabetes
(2021)Purpose: The time constant of phase II pulmonary oxygen uptake kinetics ([Formula: see text]) is increased when high-intensity exercise is initiated from an elevated baseline (work-to-work). A high-intensity priming exercise ... -
Removal of Synaptic Ca2+-Permeable AMPA Receptors during Sleep.
(2011)here is accumulating evidence that sleep contributes to memory formation and learning, but the underlying cellular mechanisms are incompletely understood. To investigate the impact of sleep on excitatory synaptic transmission, ... -
SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis.
(2008)Peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator-1alpha (PGC-1alpha) is a highly regulated transcriptional coactivator that coordinates energy metabolism in mammals. Misregulation of PGC-1alpha has ...
