Physiology
Collections in this Academic/Research Unit
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Physiology (Live Theses)
Physiology (Live Theses) -
Physiology (Scholarly Publications)
Physiology (Scholarly Publications) -
Physiology (Theses and Dissertations)
Physiology (Theses and Dissertations)
Recent Submissions
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Investigating the Immune System in Parkinson's Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2024)In 1817 James Parkinson first described the symptoms of the Parkinson's disease (PD). It is the second most common neurodegenerative disease worldwide, and cases are rising exponentially. Characteristic hallmarks of PD ... -
Investigating the therapeutic utility of Olaparib in Metachromatic Leukodystrophy and Krabbe Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2024)Leukodystrophies encompass a diverse group of genetically-based disorders that impact the development and preservation of myelin in the central nervous system's white matter. These conditions, affecting approximately 1 in ... -
The Impact and Influence of Sports Related Concussion and Cardiovascular Risk Factors on Brain and Heart Health across an Ageing Population
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)This study focused on the relationship between perceptual performance, brain health, and cardiovascular (CV) profiles in both recreational athletes and non-athletes, bridging the gap between sensory integration, cognitive ... -
Identifying the therapeutic potential of novel compounds in the treatment of Glioblastoma Multiforme
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)Glioblastoma multiforme (GBM) is the most common and aggressive brain cancer in adults with a dismal 5-year survival rate of <5%. Despite advanced diagnostic and multimodal treatments including surgery, followed by ... -
Antipsychotics Prevent Psychosine Induced Toxicity in Glial Cells.
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)Glial cells are implicated in the neuropathophysiology of schizophrenia and other neuropsychiatric disorders. Also, the role of altered myelin in the onset and development of schizophrenia and changes in myelin due to ... -
Low-volume HIIT and MICT speed VO2 kinetics during high-intensity "work-to-work" cycling with a similar time-course in type 2 diabetes
(2022)We assessed the rates of adjustment in oxygen uptake (V̇o2) and muscle deoxygenation [i.e., deoxygenated hemoglobin and myoglobin, (HHb + Mb)] during the on-transition to high-intensity cycling initiated from an elevated ... -
Priming exercise accelerates oxygen uptake kinetics during high-intensity cycle exercise in middle-aged individuals with type 2 diabetes
(2022)Background: The primary phase time constant of pulmonary oxygen uptake kinetics ( ⋅VO2 τ p) during submaximal efforts is longer in middle-aged people with type 2 diabetes (T2D), partly due to limitations in oxygen supply ... -
Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine
(2022)One area of microglial biology that has been relatively neglected until recently is sex differences and this is in spite of the fact that sex is a risk factor in several diseases that are characterized by neuroinflammation ... -
Central and peripheral characterisation of TLR7/8 and endocannabinoid signalling in multiple sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2022)Toll-like receptors (TLRs) are a class of pattern-recognition receptors (PRRs) involved in initiating an immune response to infection or endogenous damage. These receptors are expressed on cells of both the innate and ... -
Effects on an acute priming exercise and high-intensity interval training on oxygen uptake and muscle deoxygenation kinetics in older individuals with type 2 diabetes
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2021)Peak oxygen uptake (V̇O2peak) is consistently reduced in individuals with type 2 diabetes (T2D) of all ages compared with non-diabetic (ND) controls. In middle-aged (between 45 to 60 y) individuals with T2D these reductions ... -
Elucidating the complex organization of neural micro-domains in the locust Schistocerca gregaria using dMRI
(2021)To understand brain function it is necessary to characterize both the underlying structural connectivity between neurons and the physiological integrity of these connections. Previous research exploring insect brain ... -
From Mechanisms to Analgesia: Towards the Use of Non-Invasive Neuromodulation for Pain Relief in the Clinic
(Intech Open, 2020)The use of electricity for analgesic effects has a long history and yet currently neuromodulation devices based on electrical stimulation are typically restricted to being a last resort intervention for pain patients after ... -
The interactions of apolipoprotein E and inflammation in human iPSC-derived astrocytes
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Alzheimer’s disease (AD) is a devastating neurodegenerative disease characterised histologically by the presence of extracellular plaques and intracellular neurofibrillary tangles, and clinically by memory ... -
Targeting the Sphingosine 1-Phosphate Axis as a Therapeutic Strategy in Krabbe's Disease: A Pre-Clinical Study.
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Krabbe's disease (KD, globoid cell leukodystrophy) is a rare infantile neurodegenerative disorder, caused by the defective gene galc encoding the lysosomal hydrolase galactosylceramidase (GALC). A subsequent decreased ... -
Influence of type 2 diabetes on muscle deoxygenation during ramp incremental cycle exercise
(2019)We tested the hypothesis that type 2 diabetes (T2D) alters the profile of muscle fractional oxygen (O2) extraction (near-infrared spectroscopy) during incremental cycle exercise. Seventeen middle-aged individuals with ... -
Priming exercise accelerates pulmonary oxygen uptake kinetics during "work-to-work" cycle exercise in middle-aged individuals with type 2 diabetes
(2021)Purpose: The time constant of phase II pulmonary oxygen uptake kinetics ([Formula: see text]) is increased when high-intensity exercise is initiated from an elevated baseline (work-to-work). A high-intensity priming exercise ... -
A 2.5min cold water immersion improves prolonged intermittent sprint performance
(2019)Objectives: We investigated if cold water immersion (CWI) affects exercise performance during a prolonged intermittent sprint test (IST), designed to mimic activity patterns of team-sports. Design: Randomized-crossover ... -
Effect of low recumbent angle on cycling performance, fatigue and VO2 kinetics.
(2013)Purpose: This study aimed to examine the effect of the degree of inclination from upright to supine postures on cycling performance, fatigue, and oxygen uptake (V˙O(2)) kinetics. Methods: In experiment 1, 10 subjects ... -
Assessing Toll-like receptor 3/4 signalling as a phytocannabinoid target in immune cells
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Toll-like receptors (TLRs) are the sensors of pathogen associated molecules that trigger tailored innate immune intracellular signalling responses. TLRs are expressed on cells of the immune system and play an important ... -
Investigating the Effects of FTY720 on Spatial Memory and Neuroinflammation in a Rodent Model of Alzheimer's Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Alzheimer's disease (AD) is a progressive, age-related neurodegenerative disorder characterized by memory loss and cognitive decline, with loss of global functioning over time eventually leading to death. At the molecular ...