Physiology (Scholarly Publications): Recent submissions
Now showing items 101-120 of 138
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Effect of body tilt angle on fatigue and EMG activities in lower limbs during cycling
(2010)This study compared the rate of fatigue and lower limb EMG activities during high-intensity constantload cycling in upright and supine postures. Eleven active males performed seven cycling exercise tests: one upright graded ... -
Immunology meets neuroscience - opportunities for immune intervention in neurodegenerative diseases
(2011)Neuroinflammatory changes are characteristic of many, if not all, neurodegenerative diseases but the extent to which the immune system is involved in the pathogenesis of these diseases is unclear. The findings of several ... -
The kinematics of phonotactic steering in the cricket Gryllus bimaculatus
(2011)Female crickets, Gryllus bimaculatus, are attracted by the male calling song and approach singing males; a behaviour known as phonotaxis. Even tethered females walking on a trackball steer towards a computer-generated male ... -
A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus
(Elsevier, 2011)Neuroglial activation is a typical hallmark of ageing within the hippocampus, and correlates with age-related cognitive deficits. We have used quantitative immunohistochemistry and morphometric analyses to investigate ... -
Androgen receptor signaling in prostate cancer development and progression
(Carcinogenesis Press, 2011)The androgen receptor (AR) signaling axis plays a critical role in the development, function and homeostasis of the prostate. The classical action of AR is to regulate gene transcriptional processes via AR nuclear ... -
Analysing the operative experience of basic surgical trainees in Ireland using a web-based logbook
(BioMed Central, 2011)Background: There is concern about the adequacy of operative exposure in surgical training programmes, in the context of changing work practices. We aimed to quantify the operative exposure of all trainees on the National ... -
Neuropathology in Mice Expressing Mouse Alpha-Synuclein
(PLoS, 2011)?-Synuclein (?SN) in human is tightly linked both neuropathologically and genetically to Parkinson's disease (PD) and related disorders. Disease-causing properties in vivo of the wildtype mouse ortholog (m?SN), which carries ... -
Long-term potentiation is impaired in CD200-deficient mice: a role for Toll-like receptor activation.
(2011)The membrane glycoprotein CD200 is expressed on several cell types including neurons whereas expression of its receptor, CD200R, is restricted principally to cells of the myeloid lineage, including microglia. The interaction ... -
Removal of Synaptic Ca2+-Permeable AMPA Receptors during Sleep.
(2011)here is accumulating evidence that sleep contributes to memory formation and learning, but the underlying cellular mechanisms are incompletely understood. To investigate the impact of sleep on excitatory synaptic transmission, ... -
Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain
(2011)Abstract: Background: Microglial function is modulated by several factors reflecting the numerous receptors expressed on the cell surface, however endogenous factors which contribute to the age-related increase in microglial ... -
Neuroinflammatory changes increase the impact of stressors on neuronal function.
(2009)In the last few years, several research groups have reported that neuroinflammation is one feature common to several neurodegenerative diseases and that similar, although perhaps less profound, neuroinflammatory changes ... -
Effect of type 2 diabetes on the dynamic response characteristics of leg vascular conductance during exercise
(2011)In this study we tested the hypothesis that type 2 diabetes impairs the dynamic response of leg vascular conductance (LVC) during exercise. LVC (leg blood flow/mean arterial pressure) responses were studied during intermittent ... -
Age-related neuroinflammatory changes negatively impact on neuronal function.
(2010)Neuroinflammatory changes, characterized by an increase in microglial activation and often accompanied by upregulation of inflammatory cytokines like interleukin-1? (IL-1?), are common to many, if not all, neurodegenerative ... -
Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro.
(2009)Several neurodegenerative disorders are associated with evidence of inflammation, one feature of which is increased activation of microglia, the most likely cellular source of inflammatory cytokines like interleukin-1b. ... -
Bimodal magnetic-fluorescent nanostructures for biomedical applications
(2009)Magnetite-based polyelectrolyte-coated nanostructures were fabricated and the potential for biomedical application assessed in mixed glial cell cultures with nanostructure cellular internalization, cytotoxicty and contribution ... -
SIGIRR modulates the inflammatory response in the brain
(Elsevier, 2010)One of the more recently described members of the interleukin-1 (IL-1) receptor family, single-Ig-Interleukin-1 related receptor (SIGIRR), has been identified as a negative regulator of inflammation in several tissues. ... -
The age- and amyloid-beta-related increases in Nogo B contribute to microglial activation
(2011)The family of reticulons include 3 isoforms of the Nogo protein, Nogo A, Nogo B and Nogo C. Nogo A is expressed on neuronal tissue and its primary effect is widely acknowledged to be inhibition of neurite outgrowth. Although ... -
Noradrenaline reuptake inhibitors limit neuroinflammation in rat cortex following a systemic inflammatory challenge: implications for depression and neurodegeneration.
(Cambridge University Press, 2009)Evidence suggests that noradrenaline has a tonic anti-inflammatory action in the central nervous system (CNS) via its ability to suppress microglial and astrocytic activation, and inhibit production of inflammatory mediators. ... -
Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide-induced dysfunction in rat hippocampus
(Wiley & Sons, 2004)Eicosapentaenoic acid (EPA) protects hippocampus from age-related and irradiation-induced changes that lead to impairment in synaptic function; the evidence suggests that this is due to its anti-inflammatory effects, ... -
Tissue Engineering of Cartilage; Can Cannabinoids Help?
(2010)This review discusses the role of the cannabinoid system in cartilage tissue and endeavors to establish if targeting the cannabinoid system has potential in mesenchymal stem cell based tissue-engineered cartilage repair ...
