Physiology (Scholarly Publications): Recent submissions
Now showing items 41-60 of 138
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Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes
(2016)Check TCD e-journals(opens in a new window)|View at Publisher| RIS export | Download | Add to List | More... Journal of Neuroinflammation Volume 13, Issue 1, February 08, 2016, Article number 31 Open ... -
The EBI2 signalling pathway plays a role in cellular crosstalk between astrocytes and macrophages
(2016)EBI2 is a G protein-coupled receptor activated by oxysterol 7α, 25-dihydroxycholesterol (7α25HC) and regulates T cell-dependant antibody response and B cell migration. We recently found EBI2 is expressed in human astrocytes, ... -
The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures
(2016)Background BAF312 (Siponimod) is a dual agonist at the sphingosine-1 phosphate receptors, S1PR1 and S1PR5. This drug is currently undergoing clinical trials for the treatment of secondary progressive multiple sclerosis ... -
Long-term culture of pluripotent stem-cell-derived human neurons on diamonds" A substrate for neurodegeneration research and therapy
(2015)Brain Computer Interfaces (BCI) currently represent a field of intense research aimed both at understanding neural circuit physiology and at providing functional therapy for traumatic or degenerative neurological conditions. ... -
The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell deat
(2014)The parkin-associated endothelial-like receptor (PAELR, GPR37) is an orphan G protein-coupled receptor that interacts with and is degraded by parkin-mediated ubiquitination. Mutations in parkin are thought to result in ... -
Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP.
(2014)The intestinal microbiota is increasingly recognized as a complex signaling network that impacts on many systems beyond the enteric system modulating, among others, cognitive functions including learning, memory and ... -
Pressure pain thresholds increase after preconditioning 1 Hz repetitive transcranial magnetic stimulation with transcranial direct current stimulation.
(2014)BACKGROUND: The primary motor cortex (M1) is an effective target of non-invasive cortical stimulation (NICS) for pain threshold modulation. It has been suggested that the initial level of cortical excitability of M1 plays ... -
Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli
(2015)Background Lipopolysaccharide (LPS) and interferon-γ (IFNγ) increase expression of tumour necrosis factor-α (TNFα) that characterizes the M1 activation state of macrophages. Whereas it is accepted that the immune system ... -
Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice
(2015)There is a wealth of evidence indicating that macrophages adopt distinct phenotypes when exposed to specific stimuli and, in the past few years, accumulating data suggest that microglia behave somewhat similarly. Therefore, ... -
Cardiovascular Control during Exercise in Type 2 Diabetes Mellitus
(2015)Controlled studies of male and female subjects with type 2 diabetes mellitus (DM) of short duration (~3–5 years) show that DM reduces peak (L·min−1 and mL·kg−1·min−1) by an average of 12–15% and induces a greater slowing ... -
Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide
(2004)The mechanisms underlying the inhibition of long-term potentiation (LTP) induction by amyloid -peptide (A ) were investigated in the medial perforant path of the rat and mouse dentate gyrus in vitro . Evidence ... -
α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR.
(2015)The immunoregulatory function of single-Ig-interleukin-1 related receptor (SIGIRR) is derived from its ability to constrain the inflammatory consequences of interleukin (IL)-1R and toll-like receptor (TLR)4 activation. ... -
Bone Marrow-Derived Macrophages from AβPP/PS1 Mice are Sensitized to the Effects of Inflammatory Stimuli.
(2015)Macrophages are key cells in tissue defense in the periphery and, under certain circumstances, infiltrate the central nervous system, where they may play a similar role in the brain, perhaps supporting the function of ... -
Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia.
(2013)Accumulating evidence continues to underpin the role of the innate immune system in pathologies associated with neuroinflammation. Innate immunity is regulated by pattern recognition receptors that detect pathogens, and ...
