Browsing Clinical Microbiology (Theses and Dissertations) by Date of Publication
Now showing items 21-28 of 28
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Investigations of Aspergillus infection in Cystic Fibrosis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2015)Aspergillus fumigatus is a ubiquitous saprophytic fungus that is a pathogen in principally immunocompromised hosts. It is the most common fungal pathogen in Cystic Fibrosis (CF), most often associated with Allergic ... -
Molecular epidemiology, cluster analysis, and drug resistance prediction of Mycobacterium tuberculosis complex in Ireland using conventional methods and Whole Genome Sequencing
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2017)Tuberculosis (TB), caused by Mycobacterium tuberculosis Complex (MTBC), is the joint leading cause of death worldwide due to a single infectious agent, with HIV/AIDS, and remains a major challenge to public health in both ... -
Characterisation and Molecular Epidemiology of Mycobacterium chimaera isolates in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Microbiology, 2019)Mycobacterium chimaera is a slow-growing nontuberculous Mycobacterium spp. that is now recognized as a separate species within the Mycobacterium avium Complex (MAC). In the past, M. chimaera was mainly associated with ... -
Investigating the Role of Extracellular Polysaccharides in Biofilm Formation of Klebsiella pneumoniae
(Trinity College Dublin. School of Medicine. Discipline of Clinical Microbiology, 2020)Klebsiella pneumoniae (K. pneumoniae) is the most significant and clinically relevant species in the Klebsiella genus of Enterobacteriaceae and is the causative agent of a variety of infections, including pneumonia, urinary ... -
Evaluation of an in-house six-well screening plate as a means of detecting phenotypic triazole resistance in St. James's Hospital, Dublin with emphasis on Aspergillus fumigatus
(Trinity College Dublin. School of Medicine. Discipline of Clinical Microbiology, 2022)Aspergillus fumigatus is a ubiquitous saprophytic mould fungus found in nature. This fungus is present in the air, in soil, in foliage in our food stock and on inanimate surfaces. For healthy individuals, A. fumigatus poses ... -
Diverse Roles for the Extracellular Glycome of Extra-intestinal Pathogenic Escherichia coli in Serum Resistance and more
(Trinity College Dublin. School of Medicine. Discipline of Clinical Microbiology, 2023)Extra-intestinal pathogenic Escherichia coli (ExPEC) is a major cause of urinary tract infections, bacteraemia, and sepsis. This laboratory, among others, has previously shown that prototypic urosepsis strain CFT073 is ... -
Evaluating the role of angiogenesis in disease behaviour and therapy response in ulcerative colitis
Introduction Ulcerative colitis (UC) is a chronic inflammatory condition with a significant impact on quality of life. In this thesis two small molecule anti-angiogenic and anti-inflammatory agents were used to treat tissue ... -
Evaluation of Next-Generation Sequencing to Investigate the Epidemiology of Clostridioides difficile Infection
Introduction: Clostridioides difficile (C. difficile) is an anaerobic bacteria, which can cause gastrointestinal infection. There are approximately 2,000 cases of C. difficile infection (CDI) diagnosed in Ireland per year, ...