Browsing Psychiatry (Scholarly Publications) by Title
Now showing items 294-313 of 361
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Psychiatric Genetics in the post genome age
(The Royal College of Psychiatrists, 2003)Less than 50 years after publication of the structure of DNA, we possess a working draft of the human genome and expect a completed draft listing all genes and their location by 2003 (International Human Genome Sequencing ... -
Psychosis Susceptibility Gene ZNF804A and Cognitive Performance in Schizophrenia
(2010)Background: The Zinc Finger Protein 804A gene (ZNF804A) has been implicated in schizophrenia (SZ) susceptibility by several genome-wide association studies (GWAS). ZNF804A is brain-expressed, but of unknown function. ... -
The Psychosis Susceptibility gene ZNF804A: associations, functions and phenotypes
(2010)As the first gene to have achieved genome-wide significance for psychosis, ZNF804A has predictably been a subject of intense research activity. We review the evidence to date for the association between schizophrenia and ... -
A randomized controlled trial of cognitive remediation for a national cohort of forensic patients with schizophrenia or schizoaffective disorder
(2019)Background: Evidence is accumulating that Cognitive Remediation Training (CRT) is effective for ameliorating cognitive deficits experienced by patients with schizophrenia and accompanying functional impairment. There has ... -
A Randomized, Controlled Trial With 6-Month Follow-Up of Repetitive Transcranial Magnetic Stimulation and Electroconvulsive Therapy for Severe Depression
(American Psychiatric Association, 2007)OBJECTIVE: Repetitive transcranial magnetic stimulation (rTMS) has been reported to be as effective as electroconvulsive therapy (ECT) for major depression. The authors conducted a multicenter randomized, controlled trial ... -
Rare chromosomal deletions and duplications increase risk of schizophrenia.
(2008)Schizophrenia is a severe mental disorder marked by hallucinations, delusions, cognitive deficits and apathy, with a heritability estimated at 73-90% (ref. 1). Inheritance patterns are complex, and the number and type of ... -
Rare Pathogenic Copy Number Variation in the 16p11.2 (BP4–BP5) Region Associated with Neurodevelopmental and Neuropsychiatric Disorders:A Review of the Literature
(2020)Copy number variants (CNVs) play an important role in the genetic underpinnings of neuropsychiatric/neurodevelopmental disorders. The chromosomal region 16p11.2 (BP4–BP5) harbours both deletions and duplications that are ... -
Reappraising the long-term course and outcome of psychotic disorders: the AESOP-10 study.
(2014)BACKGROUND: Studies of the long-term course and outcome of psychoses tend to focus on cohorts of prevalent cases. Such studies bias samples towards those with poor outcomes, which may distort our understanding of ... -
Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depression.
(2013)BACKGROUND: Family history of major depressive disorder (MDD) increases individuals' vulnerability to depression and alters the way depression manifests itself. Emotion processing and attention shifting are functions ... -
Recurrent Rearrangements of Chromosome 1q21.1 and Variable Pediatric Phenotypes
(Massachusetts Medical Society, 2008)Background Duplications and deletions in the human genome can cause disease or predispose persons to disease. Advances in technologies to detect these changes allow for the routine identification of submicroscopic imbalances ... -
Regional Variation in Electroconvulsive Therapy Use
(2011)Although electroconvulsive therapy (ECT) is the most powerful treatment for depression, substantial variability in use has been described in Ireland. The Mental Health Commission collects usage data from approved centres ... -
Relapse following successful electroconvulsive therapy for major depression: A meta-analysis
(2013)High rates of early relapse following electroconvulsive therapy (ECT) are typically reported in the literature. Current treatment guidelines offer little information to clinicians on the optimal nature of maintenance therapy ... -
The relationship between ADHD and key cognitive phenotypes is not mediated by shared familial effects with IQ
(2011)Background. Twin and sibling studies have identified specific cognitive phenotypes that may mediate the association between genes and the clinical symptoms of attention deficit hyperactivity disorder (ADHD). ADHD is also ... -
Relationship between obesity and the risk of clinically significant depression: Mendelian randomisation study.
(2014)BACKGROUND: Obesity has been shown to be associated with depression and it has been suggested that higher body mass index (BMI) increases the risk of depression and other common mental disorders. However, the causal ... -
Repeated insulin-like growth factor 1 treatment in a patient with rett syndrome: a single case study.
(2014)Rett syndrome (RTT) is a devastating neurodevelopmental disorder that has no cure. Patients show regression of acquired skills, motor, and speech impairment, cardio-respiratory distress, microcephaly, and stereotyped hand ...