Browsing Psychiatry (Scholarly Publications) by Title
Now showing items 314-333 of 361
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Replication of an Association of a Promoter Polymorphism of the Dopamine Transporter Gene and Attention Deficit Hyperactivity Disorder
(Elsevier, 2009)Genetic associations for Attention Deficit Hyperactivity Disorder (ADHD), a common highly heritable childhood behavioural disorder, require replication in order to establish whether they are true positive findings. The ... -
Residential mobility among patients admitted to acute psychiatric wards
(Elsevier, 2011)Residential mobility among those with mental disorders is consistently associated with hospital admission. We studied 4485 psychiatric admissions in South London, aiming to describe the prevalence, timing and associations ... -
Resting-state connectivity deficits associated with impaired inhibitory control in non-treatment-seeking adolescents with psychotic symptoms.
(2014)OBJECTIVE: Psychotic symptoms are common in the population and index risk for a range of severe psychopathological outcomes. We wished to investigate functional connectivity in a community sample of adolescents who ... -
Rett syndrome and Fragile X: different etiology with common molecular dysfunctions
(2021)Rett syndrome (RTT) and Fragile X syndrome (FXS) are two monogenetic neurodevelopmental disorders with complex clinical presentations. RTT is caused by mutations in the Methyl-CpG binding protein 2 gene (MECP2) altering ... -
Rett syndrome in Ireland: a demographic study.
(2024)Background: Rett syndrome (RTT) is a rare neurodevelopmental condition associated with mutations in the gene coding for the methyl-CpG-binding protein 2 (MECP2). It is primarily observed in girls and affects individuals ... -
Review of statistical methodologies for the detection of parent-of-origin effects in family trio genome-wide association data with binary disease traits.
(2014)The detection of parent-of-origin effects aims to identify whether the functionality of alleles, and in turn associated phenotypic traits, depends on the parental origin of the alleles. Different parent-of-origin effects ... -
The role of rare compound heterozygous events in autism spectrum disorder.
(2020)The identification of genetic variants underlying autism spectrum disorders (ASDs) may contribute to a better understanding of their underlying biology. To examine the possible role of a specific type of compound heterozygosity ... -
The Role of Variation at AßPP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease.
(2011)Rare mutations in A?PP, PSEN1, and PSEN2 cause uncommon early onset forms of Alzheimer's disease (AD), and common variants in MAPT are associated with risk of other neurodegenerative disorders. We sought to establish whether ... -
Runs of homozygosity implicate autozygosity as a schizophrenia risk factor.
(2012)Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but ... -
Schizophrenia at a genetics crossroads: Where to now?
(2013)These are interesting times for schizophrenia genetics. The last 5 years has seen unprecedented progress, moving us from debate about putative genetic models to an understanding that susceptibility involves a complex ... -
Screening for autistic spectrum disorder at the 18-month developmental assessment: a population-based study
(2007)The objectives of this study were to assess the feasibility of administering the CHecklist for Autism in Toddlers (CHAT) at the 18-month developmental check, estimate the prevalence of screening positive for autism at the ... -
Semi-structured Interview of Moral cognitionS (SIMS)
(Trinity College Dublin, School of Medicine, Department of Psychiatry, 2018)This ‘Semi-structured Interview of Moral cognitionS’ (SIMS) is a synthesis of our experience and research in the fields of clinical/forensic psychology and forensic psychiatry. As an interview the SIMS aims to make ... -
Serotonergic System and Attention Deficit Hyperactivity Disorder (ADHD): a potential susceptibility locus at the 5-HT1B receptor gene in 270 Trios from a multi-center sample
(2002)Attention deficit hyperactivity disorder (ADHD) is a highly heritable and heterogeneous disorder, which usually becomes apparent during the first few years of childhood. Imbalance in dopamine neurotransmission has been ... -
Sex representation in neurodegenerative and psychiatric disorders' preclinical and clinical studies
(2023)Many studies show the importance of biological sex for the onset, progression, and response to treatment in brain disorders. In line with these reports, health agencies have requested that all trials, both at the clinical ... -
The SNP ratio test: pathway analysis of genome-wide association datasets
(2009)Summary: We present a tool that assesses the enrichment of significant associations from genome-wide association studies (GWAS) in a pathway context. The SNP ratio test (SRT) compares the proportion of significant to ... -
Social dysfunction in schizophrenia: An investigation of the GAF scale's sensitivity to deficits in social cognition.
(2013)BACKGROUND: Schizophrenia is accompanied by significant impairment in psychosocial functioning, which is only partially explained by clinical symptom severity. Recently, these impairments have been strongly associated ... -
Sodium-23 Magnetic Resonance Imaging has potential for improving penumbra detection but not for estimating stroke onset time
(2014)Tissue sodium concentration increases in irreversibly damaged (core) tissue following ischemic stroke and can potentially help to differentiate the core from the adjacent hypoperfused but viable penumbra. To test this, ...