Browsing Psychiatry (Scholarly Publications) by Title
Now showing items 334-353 of 361
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Spatial attentional bias as a marker of genetic risk, symptom severity and stimulant response in ADHD.
(2007)Attention-deficit hyperactivity disorder (ADHD) is a heritable childhood onset disorder that is marked by variability at multiple levels including clinical presentation, cognitive profile, and response to stimulant ... -
Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium
(2016)The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades of research using brain scans. To validate a prospective meta-analysis approach to analyzing multicenter ... -
Susceptibility (risk and protective) factors for in-patient violence and self-harm: Prospective study of structured professional judgement instruments START and SAPROF, DUNDRUM-3 and DUNDRUM-4 in forensic mental health services
(2013)Background The START and SAPROF are newly developed fourth generation structured professional judgement instruments assessing strengths and protective factors. The DUNDRUM-3 and DUNDRUM-4 also measure positive factors, ... -
Synaptosomal-Associated Protein 25 (SNAP-25) and Attention Deficit Hyperactivity Disorder (ADHD): Evidence of linkage and Association in the Irish Population.
(2002)Several lines of evidence have suggested that ADHD is a polygenic disorder produced by the interaction of several genes each of a minor effect. Synaptosomal-associated protein 25 (SNAP-25) is a presynaptic plasma membrane ... -
Synergistic Effect between Maternal Infection and Adolescent Cannabinoid Exposure on Serotonin 5HT1A Receptor Binding in the Hippocampus: Testing the "Two Hit" Hypothesis for the Development of Schizophrenia,
(2012)Infections during pregnancy and adolescent cannabis use have both been identified as environmental risk factors for schizophrenia. We combined these factors in an animal model and looked at their effects, alone and in ... -
Tailoring Cognitive Behavioral Therapy to Subtypes of Voice-Hearing.
(2015)Cognitive behavioral therapy (CBT) for voice-hearing (i.e., auditory verbal hallucinations; AVH) has, at best, small to moderate effects. One possible reason for this limited efficacy is that current CBT approaches tend ... -
Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis
(2019)Background Sequencing studies have pointed to the involvement in schizophrenia of rare coding variants in neuronally expressed genes, including activity-regulated cytoskeleton-associated protein (ARC) and N-methyl-D-aspartate ... -
Total and phosphorylated Tau protein as biological markers of Alzheimer's disease
(Elsevier, 2009)Advances in our understanding of tau-mediated neurodegeneration in Alzheimer?s disease (AD) are moving this disease pathway to center stage for the development of biomarkers and disease modifying drug discovery efforts. ... -
Transcriptome level analysis in Rett syndrome using human samples from different tissues
(BMC, 2018)The mechanisms of neuro-genetic disorders have been mostly investigated in the brain, however, for some pathologies, transcriptomic analysis in multiple tissues represent an opportunity and a challenge to understand the ... -
Transcriptomic analysis of Mecp2 mutant mice reveals differentially expressed genes and altered mechanisms in both blood and brain
(2019)Rett syndrome is a rare neuropsychiatric disorder with a wide symptomatology including impaired communication and movement, cardio-respiratory abnormalities, and seizures. The clinical presentation is typically associated ... -
Two patients walk into a clinic...a genomics perspective on the future of schizophrenia.
(BioMed Central, 2011)Progress is being made in schizophrenia genomics, suggesting that this complex brain disorder involves rare, moderate to high-risk mutations and the cumulative impact of small genetic effects, coupled with environmental ... -
Unlocking the treasure trove: From genes to schizophrenia biology
(2014)Significant progress is being made in defining the genetic etiology of schizophrenia. As the list of implicated genes grows, parallel developments in gene editing technology provide new methods to investigate gene function ... -
Use of codeine-containing medicines by Irish psychiatric in-patients before and after regulatory limitations on their supply.
(2013)Background. In recent years, concerns have been highlighted in several jurisdictions, including Ireland, regarding abuse of over-the-counter codeine-containing medicines. On the 1st of August 2010, national regulatory ... -
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.
(2012)Genome-wide association studies (GWASs) have been successful at identifying single-nucleotide polymorphisms (SNPs) highly associated with common traits; however, a great deal of the heritable variation associated with ... -
Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway.
(2014)IMPORTANCE We investigated the variation in neuropsychological function explained by risk alleles at the psychosis susceptibility gene ZNF804A and its interacting partners using single nucleotide polymorphisms (SNPs), ...