Browsing Psychiatry (Scholarly Publications) by Sponsor "Medical Research Council (MRC)"
Now showing items 1-8 of 8
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Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
(2011)Metformin is the most commonly used pharmacological therapy for type 2 diabetes. We carried out a GWA study on glycaemic response to metformin in 1024 Scottish patients with type 2 diabetes. Replication was in two cohorts ... -
Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis.
(2012)Psoriasis is a common, chronic, inflammatory skin disorder. A number of genetic loci have been shown to confer risk for psoriasis. Collectively, these offer an integrated model for the inherited basis for susceptibility ... -
Fine mapping of ZNF804A and genomime-wide significant evidence for it's involvement in Schizophrenia and bipolar disorder.
(2011)A recent genome-wide association study (GWAS) reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) and schizophrenia (P=1.61 × 10(-7)), and stronger evidence when the ... -
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.
(2012)Genetic factors have been implicated in stroke risk but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) in ischemic stroke and its subtypes in 3,548 cases and 5,972 ... -
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
(2009)We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 cases and 7,848 controls), we replicated the ... -
Interplay Between Childhood Physical Abuse and Familial Risk in the Onset of Psychotic Disorders.
(2014)Background : Childhood abuse is considered one of the main environmental risk factors for the development of psychotic symptoms and disorders. However, this association could be due to genetic factors influencing ... -
Reappraising the long-term course and outcome of psychotic disorders: the AESOP-10 study.
(2014)BACKGROUND: Studies of the long-term course and outcome of psychoses tend to focus on cohorts of prevalent cases. Such studies bias samples towards those with poor outcomes, which may distort our understanding of ...
