Psychiatry (Scholarly Publications): Recent submissions
Now showing items 141-160 of 363
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Unlocking the treasure trove: From genes to schizophrenia biology
(2014)Significant progress is being made in defining the genetic etiology of schizophrenia. As the list of implicated genes grows, parallel developments in gene editing technology provide new methods to investigate gene function ... -
Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium
(2016)The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades of research using brain scans. To validate a prospective meta-analysis approach to analyzing multicenter ... -
The correlation between reading and mathematics ability at age twelve has a substantial genetic component
(2014)Dissecting how genetic and environmental influences impact on learning is helpful for maximizing numeracy and literacy. Here we show, using twin and genome-wide analysis, that there is a substantial genetic component to ... -
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms
(2015)Atopic dermatitis and psoriasis are the two most common immune-mediated inflammatory disorders affecting the skin. Genome-wide studies demonstrate a high degree of genetic overlap, but these diseases have mutually exclusive ... -
Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci
(2016)Coeliac disease (CD) is a chronic immune-mediated disease triggered by the ingestion of gluten. It has an estimated prevalence of approximately 1% in European populations. Specific HLA-DQA1 and HLA-DQB1 alleles are established ... -
A genetic risk score combining 32 SNPs is associated with body mass index and improves obesity prediction in people with major depressive disorder.
(2015)Background Obesity is strongly associated with major depressive disorder (MDD) and various other diseases. Genome-wide association studies have identified multiple risk loci robustly associated with body mass index (BMI). ... -
Fom Child to Adult. A Longitudinal Study of Irish Children and their Families
(Criterion Press, 2005) -
Neuro-developmental Disorders with Co-Morbid Affective Disorders Sometimes Produce Psychiatric Conditions Traditionally Diagnosed as Schizophrenia
(2013)The knowledge in psychiatric genetics, neuroanatomy, functional neuroanatomy, neuropsychology, neuropsychopharmacology and clinical psychiatry, has immensely increased in the last decades. h ere, the psychiatric ... -
Pathways to Child Hospitalization
(Eastern Health Board. Dublin, 1988) -
Familiality and SNP heritability of age at onset and episodicity in major depressive disorder.
(2015)BACKGROUND: Strategies to dissect phenotypic and genetic heterogeneity of major depressive disorder (MDD) have mainly relied on subphenotypes, such as age at onset (AAO) and recurrence/episodicity. Yet, evidence on ... -
Relationship between obesity and the risk of clinically significant depression: Mendelian randomisation study.
(2014)BACKGROUND: Obesity has been shown to be associated with depression and it has been suggested that higher body mass index (BMI) increases the risk of depression and other common mental disorders. However, the causal ... -
Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a mendelian randomization analysis.
(2014)Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, the molecular mechanisms linking cholesterol ... -
Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants.
(2014)Objective Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) often co-occur and share genetic risks. The aim of this analysis was to determine more broadly whether ADHD and ASD share ... -
Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway.
(2014)IMPORTANCE We investigated the variation in neuropsychological function explained by risk alleles at the psychosis susceptibility gene ZNF804A and its interacting partners using single nucleotide polymorphisms (SNPs), ... -
Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study.
(2014)Genome-wide studies for SA were conducted in the RADIANT and GSK-Munich recurrent depression samples and London Bipolar Affective Disorder Case-Control Study (BACCs) then meta-analysis was performed. A GWAS on suicidal ... -
The phenotypic manifestations of rare genic CNVs in autism spectrum disorder.
(2014)Significant evidence exists for the association between copy number variants (CNVs) and Autism Spectrum Disorder (ASD); however, most of this work has focused solely on the diagnosis of ASD. There is limited understanding ...
