Biochemistry (Theses and Dissertations): Recent submissions
Now showing items 101-120 of 333
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Pre-clinical evaluation of targeting autophagy for the treatment of Oral Squamous Cell Carcinoma
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Oral Squamous Cell Carcinoma (OSCC) is the sixth most common form of cancer worldwide. It is typically aggressive and closely correlated with disease recurrence and poor survival. Chemoresistance is a critical problem ... -
NK cell function and metabolism in human cancer
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Natural Killer (NK) cells are important anti-cancer innate immune cells. They are essential for cancer immunosurveillance and their activity is associated with better outcome in cancer patients. Some of their key ... -
The Immunomodulatory Metabolite Itaconate Regulates NLRP3 Inflammasome Activation and Type I Interferon Signalling
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)The NLRP3 inflammasome is a multi-protein complex which activates caspase-1 for the cleavage and release of mature IL-1β and IL-18. Caspase-1 also cleaves gasdermin D, driving a process called pyroptosis. Results from ... -
Identification of novel innate immune mechanisms regulating oesophageal adenocarcinoma (OAC) progression and bacterial infection
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Inflammation is an essential immune system response to pathogens, damaged cells and stress stimuli and has an essential role in tissue repair and regeneration. The inflammatory response is the coordinated activation of ... -
Evidence of a role for Interleukin-6 in anoikis resistance and bioenergetic programming in oral squamous cell carcinoma
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Oral squamous cell carcinoma (OSCC) is the sixth most common type of cancer in the world and accounts for more than 90% of oral malignancies. Oral squamous cell carcinomas are usually preceded by oral premalignant ... -
Immune dysfunction in the skin disease hidradenitis suppurativa
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Hidradenitis suppurativa (HS) is a chronic, relapsing, inflammatory skin disease. Painful lesions and boils present at hair follicles of the inframammary fold, genitals, groin, buttocks and perianal areas. Severe cases ... -
Characterisation of Membrane Glycoproteins that are Essential for Flagellar Attachment in the Bloodstream Form of Trypanosoma brucei
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)The African trypanosome, Trypanosoma brucei, is a unicellular parasitic protist that causes a severe disease, trypanosomiasis, in humans and livestock in sub-Saharan Africa. The trypanosome has a single flagellum that ... -
Evaluation of the anti-cancer effects of a novel guanidinium-based compound, VP79s, in multiple myeloma
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Multiple myeloma (MM) is an incurable haematological malignancy accounting for 300-350 cancer diagnoses in Ireland each year. Mainly a disease of the elderly, MM is most prevalent in Western societies where aging populations ... -
Citrate, oxaloacetate and 2-hydroxyglutarate in the control of inflammatory macrophage activation
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Immunometabolism is the study of changes that occur in the metabolic pathways of an immune cell during its activation. For macrophages, the remodelling of their metabolism following activation supports the adoption of ... -
HAMLET and synthetic derivatives as pre-operative agents in the treatment of oral and oesophageal cancer
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Oral and oesophageal cancers are aggressive tumours that are frequently diagnosed late, with high morbidity, mortality, and difficulties in surgical and therapeutic intervention. Novel imaging probes could assist in early ... -
The immunomodulatory properties of L-rhamnose
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)L-Rhamnose is a non-mammalian monosaccharide ubiquitously found on the surface of both commensal and pathogenic bacteria. Previous publications had identified that L-rhamnose-rich Mycobacterium tuberculosis glycolipids, ... -
Inflammasome Involvement in Barrett's and Oesophageal Adenocarcinoma
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Barrett's oesophagus is an inflammatory condition and a neoplastic precursor to oesophageal adenocarcinoma (OAC). Inflammasome signalling pathways contribute to acute and chronic inflammation, and can be enhanced by obesity. ... -
Characterisation of the immune response to calcium phosphate particulates; implications for osteoarthritis and bone tissue engineering
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Early trauma, resulting in focal areas of cartilage damage with injury to the underlying subchondral bone (osteochondral damage) often progresses to arthritis. These so called osteochondral defects (OCDs) can arise from ... -
A novel role of SOCS-4 and SOCS-5 in cytokine signalling
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)The immune system is propagated by cytokines and their intracellular signal transduction. To ensure an appropriate immune response, these signalling pathways are tightly controlled. One such regulatory mechanism is the ... -
Modulation of macrophage responses by the vaccine adjuvant alum
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Recent findings have challenged the classical view of innate versus adaptive immunity, suggesting that innate cells can retain some memory of past immunological insults. This trained immunity which allows for primed cellular ... -
Sterol Regulatory Element Binding Proteins; Central Metabolic Regulators of Natural Killer Cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Natural killer (NK) cells have important functions in the immune response against pathogen- infected and transformed cells. NK cell metabolism is crucial for NK cell effector functions. In this study sterol regulatory ... -
The Role of miR-155 in Myeloid cells during Experimental Autoimmune Encephalomyelitis
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterised by multifocal demyelinating lesions with associated neuronal damage. Although MS is a CD4+ T cell-mediated disease, ... -
PKM2 regulation of metabolism but not transcription is important for natural killer cell responses
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating signal transduction and cellular metabolism is essential for effective NK cells responses. The PKM2 isoform of the ... -
The hepatic microenvironment and immune cell recruitment in colorectal liver metastasis
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)The liver is uniquely enriched with anti-tumour immune cells. However, liver metastasis is anticipated in over half of colorectal cancer patients. The value of the type and location of immune cells to prognosis has been ... -
CRISPR Gene Editing Approaches in the Study of Allergy and Infertility
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
