Biochemistry (Theses and Dissertations): Recent submissions
Now showing items 81-100 of 333
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A Bioenergetics Study of Mitochondrial Function in Bone Marrow Derived Macrophages
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Mitochondria are organelles involved in the generation of ATP, storage of intracellular calcium ions, regulation of the apoptotic pathway as well as numerous cell signalling pathways. Moreover, mitochondria are an important ... -
Modulation of hepatic autophagy for therapeutic correction of type 2 diabetes
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Glucagon is produced from pancreatic α-cells to control hepatic glucose production and glucose homeostasis. Hyperglycaemia is an early hallmark of type 2 diabetes, and therefore hepatic glucose production can contribute ... -
The role of Colony Stimulating Factor 1 Receptor in microglial phenotype and function in vitro and in vivo
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)As the brain ages multiple cellular processes become less efficient leading to a decline in cognitive and other functions, and in many cases giving rise to chronic neurodegenerative conditions such as Alzheimer’s Disease ... -
PATHOGENIC PROTEIN AGGREGATION IN VIVO AND IN VITRO
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Neurodegenerative disorders (ND) such as Alzheimer?s disease (AD), Parkinson?s disease (PD) and amyotrophic lateral sclerosis (ALS) are one of the leading causes of death and disabilities worldwide. While their aetiologies ... -
Exploration of a novel class of HO-1 inducers as potential therapeutics for inflammatory disease
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Autoimmune and inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), psoriasis, and inflammatory bowel disease (IBD) are characterised by excessive and uncontrolled inflammation. Most of these ... -
Innate resistance to hepatitis C virus infection in the Irish anti-D cohort
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Even within homogenous populations, outcome following exposure to a virus can vary substantially. This continuum of infection outcome spans viral resistance, spontaneous resolution and chronic infection, with further ... -
A study of bioenergetics and mitochondrial function in Cytotoxic T cell subsets
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)CD8 T cell fate and function have been linked to specific metabolic programs. T effector (T eff) and T memory (T mem) cells engage mitochondrial metabolism to different extents, as recognised by stark differences in ... -
The role of dietary fat in anti-tumour immunity
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Obesity increases the risk of many cancers and impairs immunosurveillance. However, little is known about whether the type of dietary fat affects tumour growth and anti-tumour immune responses. Here, we show that a ... -
Investigating a role for members of the respiratory tract microbiota in Th17 cell pathogenicity and CNS autoimmunity
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)The respiratory tract is home to a diverse microbial community whose influence on local and systemic immune responses is only beginning to be appreciated. Increasing reports have linked the airways with the trafficking ... -
Gone or Misplaced?: Investigation of Memory Engrams Across Development
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)All humans experience amnesia. While about 30% of adults who live to be over 65 will suffer from dementia, 100% of the human population experiences infantile amnesia, which is the loss of memories formed in early childhood ... -
Cyclosporine A modulates CD103+ DC responses to fungal PAMPs
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Cyclosporine A (CsA) is an immunosuppressant that protects against inflammatory diseases and graft rejection. Despite its strong efficacy, one side-effect of CsA is an increased risk of fungal infection. To minimise this, ... -
Modulation of prostaglandin production by indole-3-pyruvate and 4-octyl itaconate in proinflammatory
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)The recent surge in immunometabolism research has revealed how specific changes in the level of metabolites can affect the immune response. One important feature of the immune response is the production of a class of lipid ... -
Interactions Between Systemic Inflammation, Frailty And Neuroinflammation In Ageing And Neurodegeneration
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Compelling evidence continues to define the pivotal role which inflammation plays in the progression of neurodegenerative diseases and ageing. It has emerged that inflammation outside the brain significantly contributes ... -
Functional Relevance of Interleukin 8 Haplotype for the Innate Immune System in Holstein-Friesian Cattle
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Calves rely heavily on their innate immune response in the post-birth period before their adaptive immune system develops. Interleukin 8 (IL-8) is a major chemoattractant predominantly associated with neutrophils response ... -
The activation of unconventional T cells by Staphylococcus aureus
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Staphylococcus aureus is a major human pathogen of multiple tissue sites. The emergence of antibiotic-resistant strains promises greater morbidity in the future. No S. aureus vaccine has so far succeeded in translating ... -
Structural and Functional Studies of Lipoprotein Signal Peptidase (LspA) from Methicillin-resistant Staphylococcus aureus(MRSA)
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Antimicrobial resistance has drawn more and more attention from the world public health community and global leaders in the past decade. Staphylococcus aureus is one of the most threatening clinical pathogens and has caused ... -
Thermoregulation in the Brain and Body: Understanding the Influence of Memory on Innate Responses
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Thermoregulation is the ability for an organism to maintain a specific internal temperature while existing in an environment with constantly changing external temperatures. This is a critical homeostatic response and the ... -
Chitin-derived STING Activators as Adjuvants and Therapeutics
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)A significant challenge in the advancement of vaccine research is a lack of adjuvants that can safely drive potent cellular immunity against intracellular pathogens and cancer, a problem only exacerbated by our limited ... -
The Biochemical and Bioenergetic Consequences of the Myostatin SNP g.66493737C>T and SINE insertion 227 bp polymorphism in Skeletal Muscle of Thoroughbred Horses
(2017)The Thoroughbred horse is a tremendous athletic breed, which can be attributed to years of genetic selection for speed and stamina. This selection has led to the Thoroughbred having a very high aerobic capacity relative ... -
Helminth products promote anti-inflammatory trained innate immunity by imprinting long-term hematopoietic stem cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Recent research has shown that immunological memory is not confined to the cells of the adaptive immune system but can be imbued upon innate immune cells, including monocytes and macrophages, in a process known as trained ...
