Biochemistry (Theses and Dissertations): Recent submissions

Now showing items 121-140 of 333

    • Structural aspects of the regulation of Parkinson's Disease-associated LRRK2 Kinase by Rab GTPases 

      MCGRATH, EMMA MARGARET (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
      The Rab family of small GTPases are the premier organisers of endocytic and secretory pathways in cells. They behave as molecular 'on/off' switches and in their active GTP-bound state recruit soluble effector proteins to ...

    • Analysis of the role of Krebs cycle rewiring in macrophage cytokine production 

      RYAN, DYLAN GERARD (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
      A striking change has happened in the field of immunology whereby specific metabolic processes have been shown to be a critical determinant of immune cell activation. Multiple immune receptor types rewire metabolic pathways ...

    • An investigation into the role of TLR4 interactor with leucine rich repeats (TRIL) in Toll-like receptor responses in brain 

      Wochal, Paulina (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
      TLR4 interactor with leucine rich repeats (TRIL) was originally described as a protein required for Toll-like receptor 4 (TLR4) signalling. This thesis provides new insights into the function of TRIL within TLR signalling ...

    • Distinct local and systemic innate immune gene expression in response to Staphylococcus aureus-induced subclinical mastitis 

      Whelehan, Cormac (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)
      Both local and systemic innate immune activity has a critical role in maintaining immunological homeostasis in the mammary gland. Dysregulation of the homeostatic process leads to increased infection and related pathology, ...

    • The Queuine-Transfer RNA Pathway as a novel drug mechanism to treat Multiple Sclerosis 

      Varghese, Sreeja (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)
      Queuine is a pyrrolopyrimidine molecule that is irreversibly incorporated into the anticodon loop of transfer RNA (tRNA) for the amino acids Asparagine, Aspartate, Tyrosine and Histidine. Only bacteria synthesize queuine, ...

    • Immunomodulatory properties of endogenous danger signals 

      Tynan, Graham A. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)
      The 'danger model' proposes that dying cells release specific endogenous molecules into the extracellular milieu following loss of plasma membrane integrity. This model postulates that these endogenous molecules, referred ...

    • A structural study of ALgE, transporter of alginate from Pseudomonas aeruginosa PAOI 

      Tan, Jingquan (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
      Pseudomonas aeruginosa is an opportunistic human pathogen that causes serious diseases in humans with immune system deficiencies, such as cystic fibrosis, wound infections, urinary tract infections, and blood stream ...

    • Structural and functional studies of a turmour killing protein-fatty acid complex 

      Sullivan, Louise (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
      HAMLET (Human Alpha-lactalbumin Made LEthal to Tumour cells) is a complex between the milk protein a-lactalbumin (a-LA) and a fatty acid, oleic acid (OA), and displays remarkable properties of selectively killing tumour ...

    • Immunomodulatory activity of products from the helminth parasite Fasciola hepatica 

      Stefanska, Anna M. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
      Helminths have evolved strategies to evade host immune responses and these have been shown to be associated with simultaneous subversion of immune responses towards bystander antigens. This phenomenon forms the basis of ...

    • Delineating molecular mechanisms of inflammation-induced delirium using a novel mouse model 

      Skelly, Donal (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)
      Delirium is a syndrome of acute and transient confusion with disruption of attention and cognition; it is a common but underdiagnosed neuropsychiatric condition, which is predictive of increased fimctional decline, dementia ...

    • Modulation of microRNA by toll-like receptors 

      Sheedy, Frederick (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)
      Toll-like receptors (TLRs) play a key role regulating gene expression following the detection of a pathogen by cells to bring about an inflammatory response. I investigated whether or not activation of TLRs in dendritic ...

    • Characterisation of the innate immune response to Campylobacter jejuni colonisation in the chicken intestine 

      Shaughnessy, Ronan (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)
      Campylobacter jejuni is the leading cause of gastroenteritis in humans, and chickens are the primary vector for infection. The microbe colonises the caeca of birds as a commensal, and it is hypothesised that intestinal ...

    • The mechanism of action of particulate vaccine adjuvants 

      Sharp, Fiona A. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)
      Particulate vaccine adjuvants (PVA) have been used in vaccines both experimentally and clinically for almost a century. However, the mechanisms by which adjuvants, such as alum and poly lactide-co-glycolide (PLG) ...

    • Dendritic cell mediated mucosal cross talk 

      Ruane, Darren (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
      Developing efficacious vaccines against enteric diseases is a global challenge and priority. The rational design of such vaccines requires that novel pathways of cellular recruitment to the gastrointestinal (GI) tract be ...

    • Biological roles of semicarbazide sensitive amine oxidase 

      Olivieri, Aldo (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)
      SSAO is a multifunctional protein that catalyses the oxidative deamination of primary amines, according to the overall reaction RCH2NH2 + O2 + H2O -» RCHO + NH3 + H2O2. In this work, some of the recognised physiological ...

    • Regulation of innate and adaptive immunity by the vaccine adjuvant alum 

      Oleszycka, Ewa (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
      While many licensed vaccines consist of whole or inactivated pathogens, there is a move toward vaccines based on purified antigens which although safer are generally less immunogenic and therefore require adjuvants to ...

    • Investigation of the manipulation of phagocytes by Staphylococcus aureus 

      O'Keeffe, Kate (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
      The increasing prevalence of antibiotic resistance in Staphylococcus aureus (S. aureus) heralds the advent of a "post-antibiotic era" that urgently necessitates the development of novel treatment methods such as vaccines and ...

    • Investigating the role of inflammatory caspases during disease-associated inflammation 

      Oficjalska, Katarznya (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
      Caspases are a group of proteolytic enzymes involved in the co-ordination of cellular processes such as inflammation and apoptosis. Functional mechanisms surrounding the activation and signalling pathways mediated by ...

    • Structural basis for antagonism of innate immunity by poxvirus 

      Oda, Shunichiro (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)
      Vaccinia virus encodes many proteins that antagonize our innate immune system. It has been shown that some of them adopt a Bcl-2 like fold in spite of a lack of sequence identities to the Bcl-2 superfamily. Unlike viral ...

    • A study of the glycosylphosphatidylinositol phospholipase C in Trypanosoma brucei 

      O'Byrne, Robert (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
      Trypanosoma brucei represents a clade of flagellated parasites that cause human and animal trypanosomiases in sub-Saharan Africa. The glycosylphosphatidylinositol phospholipase C (GPI-PLC) is an endogenous enzyme that has ...