Biochemistry (Theses and Dissertations): Recent submissions
Now showing items 161-180 of 333
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Cancer cell bioenergetics in response to anti-cancer agents
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Altered metabolism is a hallmark of cancer (Hanahan and Weinberg, 2011) and while genetic and molecular modifications have enabled cancers to survive the onslaught of various cancer therapies (Pillai et al., 2010), changes ... -
Tubulin-targeting antiparasitic herbicides : new insights into putative ligand-binding pockets and computational design of molecular equivalents
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Neglected diseases are a group of tropical infections which are especially endemic in lowincome populations in developing regions of Africa, Asia, and the Americas. Collectively these diseases affect more more than a biUion ... -
The relative role of IRAK-2 in TLR signalling
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Toll-like receptors (TLRs) are pattern recognition receptors that recognise microbial ligands and subsequently trigger intracellular signalling pathways involving transcription factors such as NFkB and MAPKs such as p38. ... -
Immune modulation by the helminth parasite Fasciola hepatica
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)The incidence of allergic and autoimmune disease In the developed world has Increased dramatically In the past century. This has coincided with a reduction In the Incidence of infectious disease. The hygiene hypothesis ... -
Studies on the delirium-dementia continuum : CNS effects of systemic inflammation on hypocholinergia and chronic neurodegeneration
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Peripheral inflammation can signal to the normal, healthy CNS via multiple routes. During ageing and dementia, however, the brain is particularly susceptible to the deleterious effects of such insults. Delirium is an acute ... -
Ruthenium(11) metal complexes for photodynamic therapy (PDT) or as imaging agents
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Photodynamic therapy (PDT) represents a new localised method of treatment in cancer. The therapeutic effect is mediated by the generation of reactive oxygen species (ROS) and/or the formation of singlet oxygen (1 O2), a ... -
The pathogenesis of experimental autoimmune encephalomyelitis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Multiple Sclerosis (MS) is a chronic demyelinating disorder of the central nervous system (CNS) mediated by autoantigen-specific T cells. Experimental autoimmune encephalomyelitis (EAE) is an animal model for MS driven by ... -
Structural and biophysical investigations of Rab GTPase interacting proteins
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Summary: Rab GTPases are important regulators of cell trafficking steps such as vesicle fusion, budding and motility. They are often described as 'on/off' switches, interacting with specific effectors when bound to GTP. ... -
A comparative genomics analysis of the vertebrate immune system : genes, pathways and evolution
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)All species possess a selection-honed collection of genes whose products function in unison to form a barricade to invading pathogens. The exponential increase in publicly available sequence data has allowed the application ... -
An investigation into the role of TMED1 in IL-33/ST2L singalling pathway
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)This thesis set out to characterise the GOLD domain containing protein, TMED1 which had been shown to associate with ST2L, the receptor for the cytokine IL-33 and to investigate its relationship with ST2L. -
Immunoregulatory mechanisms in the lungs of mice and humans
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)The lungs are constantly exposed to inhaled antigen during respiration. The resident immune cells must be hyporesponsive to innocuous inhaled antigen, yet capable of responding appropriately to respiratory pathogens, with ... -
SOCS3 regulation by microRNAs, cytokines and HCV
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is the principal signalling mechanism for a wide array of cytokines. Dysregulation of JAK-STAT pathway has been noted in cancer and chronic ... -
The role of metabolism, hypoxia and immunomodulatory therapy in regulating the human Treg:Th17 cell axis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Th17 cells are important pathogenic effector cells in autoimmune diseases such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS). On the other hand, regulatory T (Treg) cells play a crucial role in ... -
An investigation into the role and regulation of uncoupling protein 1 (UCP 1)
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)The use of the uncoupling protein inhibitor GDP was used to investigate UCP 1 dependent ROS production in BAT and thymus mitochondria. The effect of UCP 1 inhibition by GDP was then corroborated using UCP 1 ablated mice ... -
Towards an improved understanding of local uterine innate immunity and histological change in postpartum cows : relevance to fertility?
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)Uterine involution in postpartum (pp) cows is necessary for establishment of the next pregnancy. Endometritis perturbs involution, impairs uterine function and causes systemic illness leading to significant involuntary cow ... -
Thinking outside the NR box : advancing novel non ligand binding pocket antagonists for the human androgen receptor
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Current treatment of prostate cancer (PCa) typically involves administration of 'classical' antiandrogens, competitive inhibitors of natural androgen receptor (AR) ligands, dihydrotestosterone (DHT) and testosterone (tes), ... -
Studies on the relationship between metabolism and control of N-linked Glycosylation in CHO cells
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)The process of post-translational attachment of oligosaccharide structures to asparagine residues in nascent polypeptides is termed N-linked glycosylation. These glycan structures can influence the folding, stability, ... -
Development of novel pyrrolo-1,5-benzoxazepines as anti-cancer agents for the treatment of chronic myeloid leukaemia
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)Chronic myeloid leukaemia (CML) is characterised by the presence of a constitutively active tyrosine kinase known as Bcr-Abl. The Bcr-Abl kinase inhibitor, STI571, is the first line treatment for CML, but the recent emergence ... -
Identification of the mammalian queuine transfer RNA ribosyltransferase complex and characterisation of QTRT1 gene-trap mice deficient in queuosine modified transfer RNA
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)Queuine, or Q-base, is a modified form of 7-deazaguanine that is synthesised de novo by eubacteria, but which is obtained from food or the gut flora by eukaryotes. Q-base is enzymatically inserted into the wobble position ... -
An investigation into the physiological expression and function of mitochondrial uncoupling protein 1 in thymus
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Our study confirms the presence of mitochondrial uncoupling protein 1 in thymus. Using laser scanning confocal microscopy, we showed the constitutive expression of UCP 1 in pure thymocytes. Using a primary peptide antibody ...
