Biochemistry (Theses and Dissertations): Recent submissions
Now showing items 181-200 of 333
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NK1.1 receptor ligation or tumour interactions prime NK cells for IL2-mediated metabolic and functional responses
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)Natural Killer (NK) cells undergo a distinct metabolic response following cytokine stimulation, which involves increased rates of glycolysis and oxidative phosphorylation (OxPhos). This metabolic response is essential for ... -
The role of amines in paraganglioma, neuroblastoma and carcinoid diagnosis
(Trinity College (Dublin, Ireland). Department of Chemical Pathology, 2000)The role of urinary noradrenaline, adrenaline, dopamine, 4-hydroxy-3-methoxy-mandelic acid (HMMA) and homovanillic acid (HVA) in the diagnosis of paraganglioma especially phaeochromocytoma and in neuroblastoma is investigated. ... -
Structure-function and pharmacological studies on the mammalian serotonin transporter
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2002)In Pichia pastoris, the existing membrane ergosterol was replaced by cholesterol in an attempt to improve folding of the low affinity heterologously expressed rat serotonin transporter, as judged by means of radioligand ... -
The alcohol dehydrogenases of Bacillus stearothermophilus
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)A 1.5-kb fragment of Bacillus stearothermophilus DSM 2334 DNA was subcloned into pUC18, and the nucleotide sequence was determined. The fragment contained a complete open reading frame that encoded a 339-residue amino-acid ... -
Semicarbazide-sensitive amine oxidase & 5-HT in dental pulp
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)This thesis investigated the behavior of semicarbazide sensitive amine oxidase (SSAO) and the unique activity that it possesses towards 5-hydroxytryptamine (5-HT) in various dental pulp tissues. This summary presents the ... -
Delayed cell death in human and fish skin cell lines after exposure to UVA and UVB
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)The effects of ultraviolet radiation on humans and animals are receiving increasing attention and much interest has recently been focused on the environmental effects of UVA and UVB. This study compares the effects of UVA ... -
Investigation into the mechanism underlying the antiproliferative and apoptotic effects of pyrrolo-1,5-benzoxazepine compounds
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)A novel series of pyrrolo-1,5-benzoxazepine (PBOX) compounds have potential as anti-cancer agents. The PBOX compounds appear to be subdivided into two groups, those that exert antiproliferative effects (e.g. PBOX-21) by ... -
Modulation of innate and adaptive immune responses by intranasally delivered adjuvants
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2002)Vaccines have had a significant impact on human health for over a hundred years, resulting in the prevention of many millions of deaths each year from infectious diseases. However in recent decades, the evolution of ... -
Investigation into the mechanism by which a novel series of pyrrolo-1,5-benzoxazepine compounds induce apoptosis in chronic myelogenous leukaemia cells
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)Some members of a novel series of pyrrolo-1,5-benzoxazepine compounds induce apoptosis in human chronic myeloid leukaemia (CML) cells. A representative compound, PBOX-6, induces apoptosis in a dose- and time-dependent ... -
A biochemical oscillator : experimental and theoretical studies of the peroxidase-oxidase reaction
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)The peroxidase-oxidase (PO) reaction is the haem-peroxidase catalysed reaction of molecular oxygen with NADH, and has been shown previously to behave in an oscillatory fashion. It has been used here as a useful laboratory ... -
Investigating the role of Small G Proteins in the activation of p38 MAPK by Interleukin-1
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)This study is an investigation into the role of small G proteins in IL-1 signalling. Lethal Toxin, from Clostridium sordellii, which specifically glucosylates and thereby inactivates the low molecular weight G proteins ... -
Bacterial products as activators of NF-ϰB
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)The ability of bacterial products to potently activate NF-xB has made this transcription factor one of the most widely studied in the immune response. A greater understanding of the mechanisms and signal transduction ... -
Factors affecting mitochondrial efficiency
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)Experiments were designed to investigate for the first time in situ synaptosomal mitochondrial bioenergetic function using synaptosomes prepared from the whole brain of rats and to compare bioenergetic functions in ... -
Involvement of the low molecular weight G protein Rac1 in IL-1 signalling to NFkB activation
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)The involvement of the low molecular weight G protein Rac1 in IL-1 signal transduction has been suggested by studies that have demonstrated that a dominant negative mutant of Rac1 can inhibit IL-1-induced activation of ... -
Structural and functional analysis of Interleukin-1 F5, a novel member of the Interleukin-1 family
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2003)This study is an investigation into novel members of the Interleukin-1 (IL-1) family; IL-IF5 and IL-1F6. The classical members of the IL-1 family, including IL -1a , IL-1β and IL-18, are involved in immune responses to ... -
The development of fish epithelial cell lines and primary cultures as diagnostic tools in environmental risk assessment
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)The objective of the this study was to attempt and develop fish epithelial cellular markers as diagnostic tools for effects assessment in ecotoxicolgy using established cell lines and primary cultures. As a target group ... -
Modulation of immune responses by Fasciola hepatica-derived products
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)Helminths are successful pathogens that infect 25% of the world s population. They cause chronic infections that are associated with type-2 and regulatory immune responses that suppress host anti-parasite immune responses. ... -
Immunomodulatory therapies for autoimmune diseases
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)Multiple sclerosis (MS) and psoriasis are both T cell mediated autoimmune diseases that are triggered in genetically susceptible individuals in response to environmental factors. Th17 cells are strongly implicated in the ... -
Factors influencing the induction of immune responses with DNA vaccines
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2002)Compared with any other medical discovery vaccines have prevented more deaths and suffering. Emergence of novel pathogens accentuates the requisite for ongoing development and improvement of traditional vaccination strategies. ... -
An investigation into the expression and physiological function of mitochondrial uncoupling proteins
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)Our study provides evidence that rat thymus contains a functioning mitochondrial uncoupling protein (UCP 1). Using reverse transcriptase-polymerase chain reaction (RT-PCR), we showed that rat thymus contains UCP 1 mRNA. ...
