Biochemistry (Theses and Dissertations): Recent submissions
Now showing items 221-240 of 333
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Identification and characterisation of serotonin transporter interacting proteins
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)The serotonin transporter (SERT) is an integral plasma membrane protein that mediates the high-affinity re-uptake of the neurotransmitter serotonin from the synaptic space. SERT is of particular clinical and phannacological ... -
Studies on the three cysteines of mouse glutathione s-transferase P1
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)The present study has identified the "alkahne thiol" of mGSTP1 originally described by Phillips and Mantle (1993) as cystein e-169. In addition cysteine-47 is confirmed as the reactive "neutral" pK thiol. Cysteine-14 in ... -
Glycerol-3-phosphatase from Trypanosoma brucei brucei
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)Glycerol-3-phosphatase activity was found in both bloodstream and procyclic form o f trypanosomes with a specific activity of 35 nmol/min/mg of protein and 28 nmol/min/mg of protein respectively. The localisation of the ... -
Investigation into folate metabolism and the effects of Methotrexate on folate metabolism in relation to the MTHFR C677T mutation in cultured mammalian cells
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)An English physician in 1920 identified an anaemia seen frequently in late pregnancy which responded well to treatment with a yeast extract called marmite (Wills, 1931). She called this anaemia "pernicious anaemia of late ... -
Modulation of immune responses by filamentous haemagglutinin from Bordetella pertussis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)The aim of this study was to investigate the mechanisms by which filamentous haemagglutinin (FHA) from Bordetella pertussis modulates immune responses. FHA is an adhesion molecule of B. pertussis and facilitates bacterial ... -
Schistosoma mansoni modulation of allergic responses
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)It has been proposed that in humans infection with certain parasitic helminths may reduce the propensity to develop allergies in infected populations. Schistosoma mansoni is a parasitic trematode that is implicated as a ... -
Trafficking and regulation of the serotonin transporter
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)The serotonin transporter (SERT) is responsible for the clearance of serotonin from the synaptic cleft. Together with the norepinephrine transporter and dopamine transporter, SERT is of great interest because it is the ... -
Modulation of innate and adaptive anti-tumour immune responses
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)Cancer is the second leading cause of death in the developed world after cardiovascular disease, with almost 25 million people living with cancer worldwide. The three main therapeutic approaches for the treatment of cancer ... -
Mechanisms of immunomodulatory activity of Cholera toxin
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)Cholera toxin (CT), a major enterotoxin produced by Vibrio cholerae, is a potent mucosal adjuvant that promotes type 2 T helper cell (Th2) responses to coadministered foreign antigen. However, the mechanisms involved in ... -
Modulation of TRAF6 function by the vaccinia virus protein A52
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)Large DNA viruses, like Vaccinia virus (VACV), encode numerous proteins that are not essential for viral replication but which modulate the antiviral immune response. A number of VACV immunomodulatory proteins have been ... -
Activation of innate immunity by Bordetella pertussis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)Respiratory infection with Bordetella pertussis is associated with the induction of Th1 cells and these cells, as well as antibody and cells of the innate immune system mediate the clearance of bacteria from the lungs. ... -
The glycosylphosphatidylinositol - phospholipase C (GPI-PLC) in bloodstream forms of Trypanosoma brucei
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)The localization of the GPI-PLC in bloodstream form trypanosomes was investigated using confocal microscopy and surface labelling techniques, namely biotinylation and iodination. The confocal data indicate that the GPI-PLC ... -
Rational discovery of second generation anti-cancer ligands
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)Recently, a novel series of Pyrrolo-1,5-BenzOXazepine (PBOX) compounds have shown apoptotic activity upon numerous cancer cell lines. Importantly, they have been suggested as potential antineoplastic agents in particular ... -
Kinetic studies on biliverdin-IXalpha reductase
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)The species distribution of biliverdin-IXa reductase (BVR-A) has been reinvestigated. It appears increasingly likely that birds and amphibia have the potential to express an active biliverdin-IXa reductase. The full length ... -
The type three secretion system of Bordetella pertussis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)Despite the description of whooping cough as a vaccine preventable disease, and the implementation of extensive vaccination programs, Bordetella pertussis remains a significant cause of childhood morbidity and mortality ... -
Characterisation of the role of Bruton's tyrosine kinase in toll-like receptor signalling
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)Toll-like receptors (TLRs) are the primary surveillance system for the detection of pathogens and are crucial to the activation of the host innate response. TLRs contain an extracellular leucine rich repeat region which ... -
Regulation of innate and adaptive immune responses by synthetic and pathogen-derived immunomodulatory molecules
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)The development of new and improved vaccine formulations for human use requires the discovery of efficacious non-toxic adjuvants that enhance immune responses to poorly immunogenic purified native or recombinant antigens. ... -
Development and application of novel virtual High Throughput Screening (vHTS) Technologies
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)The development of new pharmaceutical drugs is an expensive, timeconsuming task with an often low success rate. Traditionally, once a therapeutic target and its role in disease is identified, the process of identification ... -
Investigations of the human MTHFD1 promoter, folate response and neural tube defect risk
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)Nutritional genomics seeks to identify and understand interactions between nutrients and the genome and how these can influence individual susceptibility or resistance to common disease. Gene-nutrient interactions ... -
Characterisation of the novel leucine rich repeat containing protein KIAA0644
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)This thesis reports the existence o f a novel leucine rich repeat containing protein annotated as KIAA0644 in the Kazusa DNA Research Institute database (www.Kazusa.or.jp). which was discovered in a study for proteins ...
