Biochemistry (Theses and Dissertations): Recent submissions
Now showing items 261-280 of 333
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Sterol regulatory element binding protein is a crucial regulator of natural killer cell metabolism and function
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Natural Killer (NK) cells are a lymphocyte subset that has a key role in anti-viral and anti-tumour immunity. While the concept of immunometabolism has recently been recognised as critical in determining functions of immune ... -
Vaccine-induced protective immunity to Bordetella pertussis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Whooping cough (pertussis) is an infectious disease caused by the respiratory pathogen Bordetella pertussis that is re-emerging in many developed countries, despite extensive vaccine coverage. One of the proposed reasons ... -
Modulation of innate and adaptive immunity by Fasciola hepatica
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Helminth parasites have developed highly effective mechanisms of immune subversion that helps prolong their survival in the host, resulting in the development of chronic infections. A bystander effect ... -
Biophysical Investigations of the Specificity between Rab GTPases and their Effectors
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)The specificity of protein-protein interactions is a complex process that is poorly understood and difficult to predict. Understanding the molecular basis for specificity of a protein and its binding partner requires a ... -
The circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)The response of the innate immune system to an inflammatory insult is largely dependent on time-of-day, and many inflammatory conditions are associated with dysfunctional molecular clocks within immune cells. However, the ... -
An examination of the molecular control of feed efficiency in beef cattle
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Global agriculture is faced with the enormous challenge of feeding a rapidly growing population while being cognizant of the environmental footprint of such endeavours. A consequence of increased meat consumption worldwide ... -
HUMAN HEPATIC NATURAL KILLER CELLS IN HEALTH AND MALIGNANCY
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)The adult human liver is described as an immunologically tolerogenic organ, maintaining a homeostatic environment while bombarded by dietary antigens, microbial products and metabolic by-products. The liver is also a site ... -
Biochemical characterization of the human queine insertase complex
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Queuine is a bacterial metabolite that is salvaged by almost all eukaryotic species including algae, yeast, fungi and metazoans and is incorporated into transfer RNA for the amino acids asparagine, aspartic acid, histidine ... -
The role of IL-1 and Type I IFN in CNS function
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Cytokines including interleukins (ILs) and interferons (IFNs) are induced in response to tissue injury, infection or inflammation. Peripheral cytokines signal to the healthy Central Nervous System (CNS) to produce ... -
An Analysis of Glutathionylation in the Modulation of the Critical Innate Immune Regulators Mal and NEK7
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Macrophages are critical innate immune cells that sense pathogen associated molecular patterns (PAMPs) and host-derived damage associated molecular patterns (DAMPs) through specialized Toll-like receptors (TLRs) to maintain ... -
Development of Novel Anti-Trypanosomal Compounds via Computational, In Vitro and In Vivo Methods
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Human African Trypanosomiasis is a neglected parasitic disease caused by Trypanosoma brucei, which if left untreated eventually leads to coma and death. With no successful vaccine to date, treatment relies on chemotherapy. ... -
IL-33 regulates the immune response to particulate vaccine adjuvants
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Vaccines are one of the most successful tools contributing to global health. Despite their success, further research into safe and efficient vaccination is required to address two key issues; to combat emerging infectious ... -
Malonylation of GAPDH in the inflammatory response in macrophages
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Succinylation and malonylation are two recently discovered protein post-translational modifications. They involve the attachment to lysines of metabolism-derived succinyl and malonyl groups respectively, resulting in a ... -
In-depth Analytical Platforms Facilitating Serum Glycome, Proteome and Glycoproteome Investigation for Biomarker Discovery
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Human serum is a great source of potential protein disease biomarkers because of how blood interacts with all parts of the body, allowing it to contain proteins secreted from specific tissues of interest, and due the ... -
Size regulates particulate adjuvant induced IL-10 and IL-12p70 production
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Until recently, vaccines were largely comprised of whole cell killed and attenuated pathogens. However, over recent decades, there has been a shift towards subunit vaccine development, using purified antigens which although ... -
The novel immuno-regulatory effects of the Hepatitis C Virus (HCV) protein p7
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Hepatitis C virus (HCV) is a significant global pathogen and a leading cause of liver disease. HCV is highly effective at establishing a chronic infection, however its acute infection is often asymptomatic, for reasons ... -
Investigating the role of cell wall-anchored proteins during Staphylococcus aureus skin infection and as vaccine antigens
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Staphylococcus aureus has become increasingly resistant to antibiotics and community acquired methicillin resistant S. aureus (CA-MRSA) skin and soft tissue infections (SSTIs) are occurring with increasing frequency in ... -
Molecular investigation of mitophagy in neuronal cell models
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Autophagy functions as a cellular recycling and quality control pathway and is likely responsible for maintenance of viable mitochondria by mitophagy, even though exact mechanisms remain unclear. Mitophagy is characterised ... -
The immunmodulatory properties of chitin-derived polymers are dictated by their deacetylation patterns
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)The introduction of vaccines is regarded as one of the most successful medical interventions to date, due to their effectiveness at combating diseases that require the induction of a robust immune response. However there ... -
The Effects of Low-Dose Methotrexate on Metabolism in Primary Human PBMCs
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2017)Low-dose Methotrexate (MTX) is a powerful anti-arthritic drug used in the treatment of a variety of inflammatory diseases. It is an economical drug and is easily administered, but incomplete knowledge into its mechanism ...
