Biochemistry (Theses and Dissertations): Recent submissions
Now showing items 281-300 of 333
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A Study of Mitochondrial Dynamics and Glycosylation Events in PC12 Cells and Neurons
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2017)Summary Mitochondrial dysfunction is recognised as a hallmark of many neurodegenerative diseases. Altered electron transport chain (ETC) complex activities, mitochondrial fusion/fission dynamics, mitochondrial motility ... -
An immunomodulatory role for indole-3-pyruvate, an excreted metabolite of the parasite Trypanosoma Brucei
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2017)Human African trypanosomiasis, more commonly known as sleeping sickness, is one of the world's neglected diseases. Trypanosoma brucei, an extracellular parasitic protozoan of the genus Trypanosoma, is the causative agent. ... -
Metabolic flux control of mitochondrial dynamics in cancer cells
(Trinity College Dublin. School of Engineering. Discipline of Electronic & Elect. Engineering, 2017) -
The immunomodulatory effects of NOD1 activation
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)NOD1 and NOD2 are cytosolic pathogen recognition receptors (PRRs) which detect peptidoglycan derivatives and contribute to the host defence during bacterial infection. Transgenic mice lacking NOD1 or NOD2 are susceptible ... -
Genetic variation in bulls divergent for fertility
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2017)Bovine fertility remains a critical issue underpinning the sustainability of the agricultural sector. Since the realisation of an unfavourable relationship between fertility and production traits in cattle, methods to ... -
Regulation of bovine beta-defensin expression
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2017)Beta-defensins are a class of host defence peptides with antibacterial, antiviral and immunomodulatory roles. The bovine genome contains up to 57 putative beta-defensin genes in four syntenic clusters on different chromosomes. ... -
The roles of cytoplasmic aspartate aminotransferase in trypanosoma brucei
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2017) -
α-Lactalbumin-oleic acid complex : structure function dynamics
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Human alpha-lactalbumin made lethal to tumor cells (HAMLET) and its analogues are partially unfolded protein-oleic acid complexes that exhibit selective tumoricidal activity normally absent in the native protein itself, ... -
Regulation of the immunomodulatory cytokine IL-10 by Twist2
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)Dysregulation of cytokines can lead to infectious and inflammatory diseases. The anti-inflammatory cytokine IL-10 is known to control pro-inflammatory cytokines such as TNF-a, IL-6 and IL-12. The regulation of IL-10 is ... -
The role of Ets2 in the regulation of microRNA-155
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)MicroRNA-155 (miR-155) is highly expressed in many cancers such as B cell lymphomas and myeloid leukaemia, and inflammatory disorders such as rheumatoid arthritis, atopic dermatitis and multiple sclerosis. The role of ... -
In Vitro screening of novel compounds to assess their potential as anti-cancer, biological imaging and anti-inflammatory agents
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Gold nanoparticles (AuNps) are some of the most extensively studied nanomaterials. Because of their biocompatibility, unique size- and shape- dependence, optoelectronic and catalytic properties, AuNps have attracted enormous ... -
Activation and function of mucosal gamma delta T cells
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)γδ T cells are innate-like lymphocytes characterised by rapid activation following infection or tissue injury. They are enriched in the skin and epitheliae of various organs, where breach of the barrier is likely to occur. ... -
Role of infection and T cells in disease pathogenesis in a model of Alzheimer's disease
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Alzheimer's disease (AD) is a progressive neurodegenerative disease characterised by deposits of amyloid-β (Aβ) and neurofibrillary tangles. It has been suggested that inflammatory changes are associated with disease, ... -
The characterisation of Human Vδ3 T cells
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)Human γδ T cells expressing the Vδ3 TCR make up a minor lymphocyte subset in blood but are enriched in liver and in patients with some chronic viral infections and leukemias. We analysed the frequencies, phenotypes, ... -
Induction of regulatory immune responses that control autoimmune diseases
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Regulatory T (Treg) cells play a fundamental role in suppressing excessive inflammatory responses to pathogens and in maintaining peripheral tolerance to self-antigens. A breakdown in self-tolerance or defect in Treg cells ... -
Evaluation of the anti-cancer effects of novel pyrrolo-1, 5-benzoxazepines in neuroblastoma
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Neuroblastoma, a malignancy of neuroectodermal origin, accounts for 15% of childhood cancer deaths. Despite both advances in understanding the biology of the cancer and aggressive treatment strategies, it continues to be ... -
MicroRNA regulation of the bovine mammary immune response to a mastitis pathogen
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)Bovine mastitis is an inflammation-driven disease of the mammary gland that is associated with €2 billion in yearly losses to the European dairy industry. Streptococcus uberis is now ranked amongst the most prevalent ... -
Indentification and functionality of antigens reacting with antisperm antibodies and their role in male immunoinfertility
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)Antisperm antibodies (ASA) are a leading cause of male associated infertility. The male partner of 1 in 10 couples tests positive for sperm bound antibodies with immunoglobulins of the IgG class being found in all patients ... -
The influence of particle size in adjuvant induced innate and adaptive immune responses
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Advances in vaccine development have enabled the application of adjuvanted subunit vaccines as opposed to attenuated or killed whole organisms. However the efficacy of this approach is strongly dependent on the optimisation ... -
The mechanistic characterisation of misfolding proteins in disease and cancer therapy
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Protein folding is a highly ordered and governed event which results in the production of native peptide structures capable of carrying out a myriad of functions and processes within the cell. Failure to produce fully ...
