Biochemistry (Scholarly Publications): Recent submissions
Now showing items 101-120 of 734
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Next-generation pertussis vaccines based on the induction of protective t cells in the respiratory tract
(2020)Immunization with current acellular pertussis (aP) vaccines protects against severe pertussis, but immunity wanes rapidly after vaccination and these vaccines do not prevent nasal colonization with Bordetella pertussis. ... -
Diverse Immunoregulatory Roles of Oxysterols - The Oxidized Cholesterol Metabolites
(2020)Intermediates of both cholesterol synthesis and cholesterol metabolism can have diverse roles in the control of cellular processes that go beyond the control of cholesterol homeostasis. For example, oxidized forms of ... -
Metabolic but not transcriptional regulation by PKM2 is important for Natural Killer cell responses
(2020)Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating changes in signal transduction pathways and cellular metabolism is essential for effective NK cells responses. The ... -
Characterizing caspase-1 involvement during esophageal disease progression.
(2020)Barrett’s esophagus (BE) is an inflammatory condition and a neoplastic precursor to esophageal adenocarcinoma (EAC). Inflammasome signaling, which contributes to acute and chronic inflammation, results in caspase-1 activation ... -
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, 2 Synthesis, Structural Analysis, and Biological Evaluation
(2020)Histone deacetylase inhibitors (HDACi) have emerged as promising therapeutics for the treatment of neurodegeneration, cancer, and rare disorders. Herein, we report the development of a series of spiroindoline-based HDAC6 ... -
Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity
(2020)A multitude of diverse microorganisms, termed the microbiota, reside in the gut, respi-ratory tract, skin, and genital tract of humans and other animals. Recent advances inmetagenomic sequencing and bioinformatics have ... -
Caspase-11 promotes allergic airway inflammation
(2020)Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E2 (PGE2) inhibits caspase-11-dependent pyroptosis in murine and human macrophages. PGE2 ... -
Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner
(2020)Engineering a pro-regenerative immune response following scaffold implantation is integral to functional tissue regeneration. The immune response to implanted biomaterials is determined by multiple factors, including ... -
Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism
(2020)A number of studies have demonstrated that molecules called ‘alarmins’ or danger-associated molecular patterns (DAMPs), contribute to inflammatory processes in the OA joint. Metabolic reprogramming of immune cells, including ... -
Mitochondrial localization of SESN2
(2020)SESN2 is a member of the evolutionarily conserved sestrin protein family found in most of the Metazoa species. The SESN2 gene is transcriptionally activated by many stress factors, including metabolic derangements, reactive ... -
Partial inhibition of complex I activity increases Ca2+-independent glutamate release rates from synaptosomes
(2008)Mitochondria have been implicated in the pathogenesis of several neurodegenerative disorders and, in particular, complex I (NADH:ubiquinone oxidoreductase, EC 1.6.5.3) activity has been shown to be partially reduced in ... -
Autophagy in the immune response to tuberculosis: clinical perspectives
(2011)A growing body of evidence points to autophagy as an essential component in the immune response to tuberculosis. Autophagy is a direct mechanism of killing intracellular Mycobacterium tuberculosis and also acts as a modulator ... -
Metabolic reprogramming during the Trypanosoma brucei life cycle
(2017)Cellular metabolic activity is a highly complex, dynamic, regulated process that is influenced by numerous factors, including extracellular environmental signals, nutrient availability and the physiological and developmental ... -
Retroviral reporter systems for the assessment of activity of stress-induced signal transduction pathways controlled by p53, HIF-1 and HSF-1 transcription factors
(2005)The tumor suppressor p53, hypoxia-inducible factor 1 (HIF-1), and heat-shock factor 1 (HSF-1) are the key transcription factors involved in the stress response to damage of the genetic material, hypoxia, or heat shock, ... -
Transcriptional Inhibition of the Human Papilloma Virus Reactivates Tumor Suppressor p53 in Cervical Carcinoma Cells
(2007)Inactivation of tumor suppressor p53 accompanies the majority of human malignancies. Restoration of p53 function causes death of tumor cells and is potentially suitable for gene therapy of cancer. In cervical carcinoma, ... -
Sestrins orchestrate cellular metabolism to attenuate aging
(2013)The Sestrins constitute a family of evolutionarily conserved stress-inducible proteins that suppress oxidative stress and regulate AMP-dependent protein kinase (AMPK)-mammalian target of rapamycin (mTOR) signaling. By ... -
Stressin' Sestrins take an aging fight
(2010)Sestrins (Sesns) are a family of highly conserved stress‐responsive proteins, transcriptionally regulated by p53 and forkhead transcription factor that exhibit oxidoreductase activity in vitro and can protect cells from ... -
Sestrin-2 is significantly increased in malignant pleural effusions due to lung cancer and is potentially secreted by pleural mesothelial cells.
(2016)Objectives: Sestrin-2 (Sesn2) belongs to a family of highly conserved antioxidant proteins that were discovered as p53-inducible proteins and inhibits cell growth and proliferation. Our aim was to assess the levels of Sesn2 ... -
Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death
(2016)Sestrin2 is a member of a family of stress responsive proteins, which controls cell viability via antioxidant activity and regulation of the mammalian target of rapamycin protein kinase (mTOR). Sestrin2 is induced by ... -
Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.
(2012)Chronic activation of mammalian target of rapamycin complex 1 (mTORC1) and p70 S6 kinase (S6K) in response to hypernutrition contributes to obesity-associated metabolic pathologies, including hepatosteatosis and insulin ...
