Biochemistry (Scholarly Publications): Recent submissions
Now showing items 141-160 of 734
-
CD4 TRMcells following infection and immunization: Implications for more effective vaccine design
(2018)The induction of immunological memory, which is mediated by memory T and B cells, is central to adaptive protective immunity to pathogens induced by previous infection and is the cornerstone of effective vaccine design. ... -
A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia
(2018)Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and function remains to be investigated. To investigate the effect of ... -
Evidence against a role for NLRP3-driven islet inflammation in db/db mice
(2018)Objectives: Type 2 diabetes (T2D) is associated with chronic, low grade inflammation. Activation of the NLRP3 inflammasome and secretion of its target interleukin-1β (IL-1β) have been implicated in pancreatic β cell failure ... -
An oral alpha-galactosylceramide adjuvanted Helicobacter pylori vaccine induces protective IL-1R- and IL-17R-dependent Th1 responses
(2019)Helicobacter pylori causes chronic gastric infection that can lead to peptic ulcers and is an identified risk factor for gastric cancer development. Although much effort has been put into the development of a Helicobacter ... -
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
(2019)These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid ... -
Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation
(2019)NLRP3 inflammasome activation contributes to chronic inflammationassociated with autoinflammatorydisease, yet understanding of NLRP3inflammasome regulation is incomplete.Hughes et al. show that thedeglutathionylating enzyme ... -
Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity
(2019)Astrocytes are the most numerous cell type in the brain and perform several essential functions in supporting neuronal metabolism and actively participating in neural circuit and behavioral function. They also have ... -
Novel thioglycoside analogs of α-galactosylceramide stimulate cytotoxicity and preferential Th1 cytokine production by human invariant natural killer T cells
(2018)Invariant natural killer T (iNKT) cells recognize glycolipid antigens bound to CD1d molecules on antigen-presenting cells. Therapeutic activation of iNKT cells with the xenogeneic glycolipid α-galactosylceramide (α-GalCer) ... -
Single point mutations reveal amino acid residues important for Chromobacterium violaceum transaminase activity in the production of unnatural amino acids
(2018)Unnatural amino acids (UAAs) are chiral amines with high application potential in drug discovery and synthesis of other valuable chemicals. Biocatalysis offers the possibility to synthesise novel optically pure UAAs with ... -
Natural Killer cells integrate signals received from tumour interactions and IL2 to induce robust and prolonged anti-tumour and metabolic responses
(2019)Natural Killer (NK) cells are lymphocytes with an important role in anti-tumour responses. NK cells bridge the innate and adaptive arms of the immune system; they are primed for immediate anti-tumour function but can also ... -
Immunization with whole cell but not acellular pertussis vaccines primes CD4 T <inf>RM</inf> cells that sustain protective immunity against nasal colonization with Bordetella pertussis
(2019)Protective immunity wanes rapidly after immunization of children with acellular pertussis (aP) vaccines and these vaccines do not prevent nasal colonization or transmission of Bordetella pertussis in baboons. In this study, ... -
Mitochondrial physiology.
(2020)As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. ... -
PDK1 regulation of mTOR and Hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
(2012)mTORC1 (mammalian target of rapamycin complex 1) controls transcriptional programs that determine CD8+ cytolytic T cell (CTL) fate. In some cell systems, mTORC1 couples phosphatidylinositol-3 kinase (PI3K) and Akt to the ... -
Next-generation anti�Staphylococcus aureus vaccines: A potential new therapeutic option for atopic dermatitis?
(2019)Disease severity in patients with atopic dermatitis (AD) isdirectly correlated with colonization by Staphylococcus aureus.1 An increasing body of evidence now also supports a role for Saureusin the pathogenesis of AD in ... -
Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target
(2019)Staphylococcus aureus expresses a number of cell wall-anchored proteins that mediate adhesion and invasion of host cells and tissues and promote immune evasion, consequently contributing to the virulence of this organism. ... -
Would hemodialysis patients benefit from a Staphylococcus aureus vaccine?
(2019)Staphylococcus aureus bloodstream infection can have potentially catastrophic consequences for patients on hemodialysis. Consequently, an effective vaccine to prevent S aureus infection would have a significant influence ... -
IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections.
(2017)IL-10 is a potent anti-inflammatory mediator that plays a crucial role in limiting host immunopathology during bacterial infections by controlling effector T cell activation. Staphylococcus aureus has previously been shown ... -
Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms
(2018)Systemic inflammation can impair cognition with relevance to dementia, delirium and post-operative cognitive dysfunction. Episodes of delirium also contribute to rates of long-term cognitive decline, implying that these ... -
Chronic neurodegeneration induces Type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression
(2019)Type I interferons (IFN‐I) are the principal antiviral molecules of the innate immune system and can be made by most cell types, including central nervous system cells. IFN‐I has been implicated in neuroinflammation during ... -
A mechanism for bistability in glycosylation
(2018)Glycosyltransferases are a class of enzymes that catalyse the posttranslational modification of proteins to produce a large number of glycoconjugate acceptors from a limited number of nucleotide-sugar donors. The products ...
