Biochemistry (Scholarly Publications): Recent submissions
Now showing items 241-260 of 734
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Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
(2017)The imminent threat of viral epidemics and pandemics dictates a need for therapeutic approaches that target viral pathology irrespective of the infecting strain. Reactive oxygen species are ancient processes that ... -
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity
(2017)Glutathione transferase Omega 1 (GSTO1-1) is an atypical GST reported to play a pro-inflammatory role in response to LPS. Here we show that genetic knockout of Gsto1 alters the response of mice to three distinct ... -
Recombinant BCG expressing LTAK63 adjuvant induces superior protection against Mycobacterium tuberculosis
(2017)In order to develop an improved BCG vaccine against tuberculosis we have taken advantage of the adjuvant properties of a non-toxic derivative of Escherichia coli heat labile enterotoxin (LT), LTAK63. We have constructed ... -
Enrichment of inflammatory IL-17 and TNF-α secreting CD4+ T cells within colorectal tumours despite the presence of elevated CD39+ T regulatory cells and increased expression of the immune checkpoint molecule, PD-1.
(2016)T cell infiltration into colorectal tumors has been shown to correlate with improved patient outcomes. However, more detailed information on the makeup and relationships between the infiltrating T cell subsets is lacking. ... -
Increased expression of Tbet in CD4+ T cells from clinically isolated syndrome patients at high risk of conversion to clinically definite MS.
(2016)Background: The ability to identify clinically isolated syndrome (CIS) patients at high risk of progression to clinically definite multiple sclerosis (CDMS) would be clinically beneficial. The initiation of T cell ... -
A Metabolic Roadblock in Inflammatory Macrophages
(2016)n this issue of Cell Reports, Van den Bossche et al. (2016) reveal that, once the M1 macrophage forms, the accompanying metabolic alterations in the mitochondria are irreversible, preventing differentiation into the more ... -
X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex
(2016)Serial femtosecond X-ray crystallography (SFX) using an X-ray free electron laser (XFEL) is a recent advancement in structural biology for solving crystal structures of challenging membrane proteins, including G-protein ... -
Ternary structure reveals mechanism of a membrane diacylglycerol kinase
(2015)Diacylglycerol kinase catalyses the ATP-dependent conversion of diacylglycerol to phosphatidic acid in the plasma membrane of Escherichia coli. The small size of this integral membrane trimer, which has 121 residues per ... -
Ternary structure reveals mechanism of a membrane diacylglycerol kinase
(2015)Diacylglycerol kinase catalyses the ATP-dependent conversion of diacylglycerol to phosphatidic acid in the plasma membrane of Escherichia coli. The small size of this integral membrane trimer, which has 121 residues per ... -
Turning 21: Induction of miR-21 as a key switch in the inflammatory response
(2015)miR-21 is one of the most highly expressed members of the small non-coding microRNA family in many mammalian cell types. Its expression is further enhanced in many diseased states including solid tumors, cardiac injury, ... -
Staphylococcus aureus and influenza a virus: Partners in coinfection
(2016)Nasal carriage of Staphylococcus aureus is a significant risk factor for secondary staphylococcal pneumonia in influenza A virus (IAV)-infected hosts. However, little research has been undertaken to define the environmental ... -
Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa
(2016)The local immune response occurring during Staphylococcus aureus nasal colonization remains ill-defined. Studies have highlighted the importance of T-cell immunity in controlling S. aureus colonization of the nasal mucosa. ...
