Biochemistry (Scholarly Publications): Recent submissions
Now showing items 261-280 of 734
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Advances in immunotherapy for the treatment of glioblastoma.
(2017)Glioblastoma (GBM) is an aggressive brain tumour, associated with extremely poor prognosis and although there have been therapeutic advances, treatment options remain limited. This review focuses on the use of immunotherapy, ... -
Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages
(2016)Background: Particulate matter has been shown to stimulate the innate immune system and induce acute inflammation. Therefore, while nanotechnology has the potential to provide therapeutic formulations with improved efficacy, ... -
Editorial: Immune cells in the mucosa
(2016)The importance of autophagy as a key regulator of cellular homeostasis and responsiveness to stress and infection is being increasingly appreciated as reflected in the recent award of the Nobel Prize in Physiology or ... -
A novel immunomodulatory hemocyanin from the limpet Fissurella latimarginata promotes potent anti-tumor activity in melanoma
(2014)Porous silicon (pSi) microparticles, in diverse sizes and shapes, can be functionalized to present pathogen-associated molecular patterns that activate dendritic cells. Intraperitoneal injection of MPL-adsorbed pSi ... -
Epithelial expression of inflammatory caspases-4 and -5 is specific to malignancy in colorectal cancer patients.
(American Gastroenterology Association (AGA), 2016) -
The CD4 + T cell methylome contributes to a distinct CD4 + T cell transcriptional signature in Mycobacterium bovis-infected cattle
(2016)We hypothesised that epigenetic regulation of CD4+ T lymphocytes contributes to a shift toward a dysfunctional T cell phenotype which may impact on their ability to clear mycobacterial infection. Combined RNA-seq transcriptomic ... -
Liver immunology and its role in inflammation and homeostasis
(2016)The human liver is usually perceived as a non-immunological organ engaged primarily in metabolic, nutrient storage and detoxification activities. However, we now know that the healthy liver is also a site of complex ... -
Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication.
(2016)Recent advances in immunometabolism link metabolic changes in stimulated macrophages to production of IL-1β, a crucial cytokine in the innate immune response to Mycobacterium tuberculosis. To investigate this pathway in ... -
A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.
(2016)Humans that are heterozygous for the common S180L polymorphism in the Toll-like receptor (TLR) adaptor Mal (encoded by TIRAP) are protected from a number of infectious diseases, including tuberculosis (TB), whereas those ... -
Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1.
(2015)The circadian clock allows an organism to anticipate daily changes imposed by the environment. The response to LPS is altered depending on time of day; however, the molecular mechanisms underlying this are unclear. We find ... -
Protective role for caspase-11 during acute experimental murine colitis.
(2015)Activation of the noncanonical inflammasome, mediated by caspase-11, serves as an additional pathway for the production of the proinflammatory cytokines IL-1β and IL-18. Noncanonical inflammasome activity occurs during ... -
Metformin inhibits the production of reactive oxygen species from NADH: Ubiquinone oxidoreductase to limit induction of interleukin-1β (IL-1β) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages
(2015)Background: The antidiabetic drug and mitochondrial NADH:ubiquinone oxidoreductase (complex I) inhibitor metformin has anti-inflammatory activity. Results: Complex I inhibition decreases LPS-induced IL-1β and boosts IL-10. ... -
DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease
(2015)The detection of nucleic acids by the innate immune system is an essential host response during viral infection. In recent years, a number of immune sensors capable of recognizing cytosolic DNA have been identified and ... -
Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation
(2016)The main limitation to successful transplantation is the antigraft response developed by the recipient immune system, and the adverse side effects of immunosuppressive agents which are associated with significant toxicity ... -
γδ T cells and NK cells – Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity.
(2015)Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease that affects the central nervous system (CNS) resulting in progressive cognitive decline and physical disability. Experimental autoimmune encephalomyelitis ... -
Integrated analysis of the local and systemic changes preceding the development of post-partum cytological endometritis.
(2015)BACKGROUND: The regulation of endometrial inflammation has important consequences for the resumption of bovine fertility postpartum. All cows experience bacterial influx into the uterus after calving; however a significant ...
