Biochemistry (Scholarly Publications): Recent submissions
Now showing items 61-80 of 734
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Correction: IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils
(2021)The original version of this article unfortunately contained a mistake in Fig. 3h. Due to a typesetting error the lines on the graph have been moved below the X axis. We apologize for this error. The correct Fig. 3h can ... -
Overcoming waning immunity in pertussis vaccines: Workshop of the national institute of allergy and infectious diseases
(2020)Despite high vaccine coverage in many parts of the world, pertussis is resurging in a number of areas in which acellular vaccines are the primary vaccine administered to infants and young children. This is attributed in ... -
Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells
(2020)Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing promise in clinical trials in multiple sclerosis. In this ... -
Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors
(2021)It remains unresolved how retinal pigment epithelial cell metabolism is regulated following immune activation to maintain retinal homeostasis and retinal function. We exposed retinal pigment epithelium (RPE) to several ... -
Type ii nkt cell agonist, sulfatide, is an effective adjuvant for oral heat-killed cholera vaccines
(2021)Oral vaccination has the potential to offer a safer and more efficacious approach for protection against enteric pathogens than injection-based approaches, especially in developing countries. One key advantage is the ... -
Prolonged oral coenzyme Q10-β-cyclodextrin supplementation increases skeletal muscle complex I+III activity in young Thoroughbreds
(2020)In summary, this study demonstrated that oral supplemen- tation of young, healthy untrained Thoroughbreds on a pasture and oat diet with a CoQ 10 -β-cyclodextrin inclusion complex via syringe significantly increased ... -
Cold acclimation and oxygen consumption in the thymus
(2006)Mitochondrial uncoupling protein 1 is usually associated with brown adipose tissue but has recently been discovered in rat and mouse thymus. We wished to establish whether there was a thermogenic role for UCP 1 in thymus ... -
Uncoupling mechanism and redox regulations of mitochondrial uncoupling protein UCP1
(2018)Brown adipose tissue (BAT) and brown in white (brite) adipose tissue, termed also beige adipose tissue, are major sites of mammalian nonshivering thermogenesis. Mitochondrial uncoupling protein 1 (UCP1), specific for these ... -
Effect of dietary restriction and subsequent realimentation on hepatic oxidative phosphorylation in cattle
(2021)Compensatory growth (CG) is a naturally accelerated growth which occurs upon realimentation, following a prior period of dietary restriction. The process is harnessed worldwide as a management practice to reduce feed costs ... -
Pro-inflammatory Stimulation of Monocytes by ANCA Is Linked to Changes in Cellular Metabolism
(2020)Clinical and experimental data suggest that pathogenesis in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is driven by ANCA-mediated activation of neutrophils and monocytes. While the role of neutrophils ... -
Mitochondrial abundance and function in skeletal muscle and liver from Simmental beef cattle divergent for residual feed intakee
(2020)Cellular mitochondrial function has been suggested to contribute to variation in feed efficiency (FE) among animals. The objective of this study was to determine mitochondrial abundance and activities of various mitochondrial ... -
TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer
(2021)Background Natural killer (NK) cells provide important immune protection from cancer and are a key requirement for particular immunotherapies. There is accumulating evidence that NK cells become dysfunctional during cancer. ... -
Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation
(2021)Fructose intake has increased substantially throughout the developed world and is associated with obesity, type 2 diabetes and non-alcoholic fatty liver disease. Currently, our understanding of the metabolic and mechanistic ... -
The HCV protein, p7, suppresses inflammatory responses to TNF-a via STAT3 and ERK-mediated induction of SOCS3
(2019)Viruses use a spectrum of immune evasion strategies that enable infection and replication. The acute phase of hepatitis C virus (HCV) infection is characterized by nonspecific and often mild clinical symptoms, suggesting ... -
Mycobacterium tuberculosis Limits Host Glycolysis and IL-1? by Restriction of PFK-M via MicroRNA-21
(2020)Increased glycolytic metabolism recently emerged as an essential process driving host defense against Mycobacterium tuberculosis (Mtb), but little is known about how this process is regulated during infection. Here, we ... -
Technological Approaches for Improving Vaccination Compliance and Coverage
(2020)Vaccination has been well recognised as a critically important tool in preventing infectious disease, yet incomplete immunisation coverage remains a major obstacle to achieving disease control and eradication. As medical ... -
Modulation of immune responses using adjuvants to facilitate therapeutic vaccination
(2020)Therapeutic vaccination offers great promise as an intervention for a diversity of infectious and non-infectious conditions. Given that most chronic health conditions are thought to have an immune component, vaccination ... -
Editorial: Challenges in Vaccinology
(2020)The COVID19 pandemic has focused minds as rarely before on the vital contribution of vaccines to modern life. In addition to issues related to antigen identification, vaccine adjuvants, vectors and formulations, knowledge ... -
Prevention and treatment of COVID-19 disease by controlled modulation of innate immunity
(2020)The recent outbreak of coronavirus disease 2019 (COVID‐19), triggered by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) poses an enormous threat to global public health and economies. Human coronaviruses ...
