Microbiology (Scholarly Publications): Recent submissions
Now showing items 201-220 of 238
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Regulation of transcription by DNA supercoiling in Mycoplasma genitalium: global control in the smallest known self-replicating genome.
(2011)The mollicute Mycoplasma genitalium causes sexually transmitted disease in humans. It has recently come to widespread public attention through its involvement in pioneering synthetic biology experiments. The 580-kilo-base-pair ... -
Synthesis and evaluation of phosphoramidate and phosphorothioamidate analogues of amiprophos methyl as potential antimalarial agents
(Elsevier, 2011)A series of phosphoramidate and phosphorothioamidate compounds based on the lead antitubulin herbicidal agents amiprophos methyl (APM) and butamifos were synthesised and evaluated for antimalarial activity. Of these ... -
Pervasive post-transcriptional control of genes involved in amino acid metabolism by the Hfq-dependent GcvB small RNA.
(2011)GcvB is one of the most highly conserved Hfq-associated small RNAs in Gram-negative bacteria and was previously reported to repress several ABC transporters for amino acids. To determine the full extent of GcvB-mediated ... -
Staphylococcus lugdunensis IsdG Liberates Iron from Host Heme
(2011)Staphylococcus lugdunensis is often found as part of the normal flora of human skin but has the potential to cause serious infections even in healthy individuals. It remains unclear what factors enable S. lugdunensis to ... -
The Sbi Protein Is a Multifunctional Immune Evasion Factor of Staphylococcus aureus
(2011)The second immunoglobulin-binding protein (Sbi) of Staphylococcus aureus has two N-terminal domains that bind the Fc region of IgG in a fashion similar to that of protein A and two domains that can bind to the complement ... -
Rational design of an artificial genetic switch: co-option of the H-NS-repressed proU operon by the VirB virulence master regulator
(2011)The H-NS protein represses the transcription of hundreds of genes in Gram-negative bacteria. De-repression is achieved by a multitude of mechanisms, many of which involve binding of a protein to DNA at the repressed promoter ... -
Fibrinogen is a ligand for the S. aureus MSCRAMM Bbp (Bone sialoprotein-binding protein).
(2011)MSCRAMMs (microbial surface components recognizing adhesive matrix molecules) are bacterial surface proteins mediating adherence of the microbes to components of the extracellular matrix of the host. On Staphylococci the ... -
Overexpression, purification and assessment of cyclosporin binding of a family of cyclophilins and cyclophilin-like proteins of the human malarial parasite Plasmodium falciparum
(2011)Malaria represents a global health, economic and social burden of enormous magnitude. Chemotherapy is at the moment a largely effective weapon against the disease, but the appearance of drug-resistant parasites is reducing ... -
Staphylococci and staphylococcal infections
(2010)The International Symposium of Staphylococci and Staphylococcal Infections is a biennial conference that brings together clinicians who treat staphylococcal infections in the community and in hospitals, veterinary ... -
Evolutionary Genomics of Staphylococcus aureus Reveals Insights into the Origin and Molecular Basis of Ruminant Host Adaptation
(Oxford University Press, 2010)Phenotypic biotyping has traditionally been used to differentiate bacteria occupying distinct ecological niches such as host species. For example, the capacity of Staphylococcus aureus from sheep to coagulate ruminant ... -
Genetic analysis of gentamicin resistance in methicillin- and gentamicin-resistant strains of Staphylococcus aureus isolated in Dublin hospitals.
(American Society for MIcrobiology, 1988)Methicillin- and gentamicin-resistant strains of Staphylococcus aureus isolated in Dublin hospitals have been classified into groups I, II, and III based on resistance to antimicrobial agents and plasmid profiles. Each ... -
Identification and characterization of novel Plasmodium falciparum cyclophilins and their roles in the antimalarial actions of cyclosporin A and derivatives
(BioMed Central, 2010)Cyclophilins are distributed widely among different organisms and are proposed drug targets for a number of diseases including HIV and hepatitis C infection and ischemia. Cyclophilins play roles in folding and chaperoning ... -
An Incomplete TCA Cycle Increases Survival of Salmonella Typhimurium during Infection of Resting and Activated Murine Macrophages
(PLoS, 2010)Background: In comparison to the comprehensive analyses performed on virulence gene expression, regulation and action, the intracellular metabolism of Salmonella during infection is a relatively under-studied area. We ... -
Transcriptomic analysis of Escherichia coli O157:H7 and K-12 cultures exposed to inorganic and organic acids in stationary phase reveals acidulant and strain-specific acid tolerance responses
(2010)The foodborne pathogen Escherichia coli O157:H7 is commonly exposed to organic acid in processed and preserved foods, allowing adaptation and the development of tolerance to pH levels otherwise lethal. Since little is known ... -
Clumping factor A interaction with complement factor I increases C3b cleavage on the bacterial surface of Staphylococcus aureus, and decreases complement-mediated phagocytosis
(2010)The human complement system is important in the immunological control of Staphylococcus aureus infection. We showed previously that S. aureus surface protein clumping factor A (ClfA), when expressed in recombinant form, ... -
The effect of mobile element IS10 on experimental regulatory evolution in Escherichia coli
(2010)Mobile genetic elements are widespread in bacteria, where they cause several kinds of mutations. Although their effects are on the whole negative, rare beneficial mutations caused by insertion sequence elements are frequently ... -
The role of Staphylococcus aureus surface protein SasG in adherence and biofilm formation
(2007)Staphylococcus aureus colonizes the moist squamous epithelium of the anterior nares. One of the adhesins likely to be responsible is the S. aureus surface protein G (SasG), which has sequence similarity with the proteins ... -
Effect of intranasal administration of Semliki Forest virus recombinant particles expressing interferon-? on the progression of experimental autoimmune encephalomyelitis.
(Spandidos, 2008)The effect of intranasal (IN) administration of Semliki Forest virus (SFV) recombinant particles expressing interferon-? [IFN-?, a partially effective treatment for multiple sclerosis (MS)] on the progression of experimental ... -
Fibronectin-binding protein B variation in Staphylococcus aureus
(2010)Background: Fibronectin binding proteins A and B (FnBPA and FnBPB) mediate adhesion of S.aureus to fibrinogen, elastin and fibronectin. We previously identified seven different isotopes of FnBPA based on divergence in the ... -
Molecular genetic typing reveals further insights into the diversity of animal-associated Staphylococcus aureus
(2009)Staphylococcus aureus is an important pathogen of man, but is also able to colonize and cause disease in a wide variety of mammals and birds. An extended multilocus sequencing approach, involving multilocus sequence typing ...
