Clinical Medicine (Theses and Dissertations): Recent submissions
Now showing items 1-20 of 355
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Asclepiades of Bithynia's Medical Molecular Theory and his Contribution to Evolving Understandings of Mental Illness
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Asclepiades of Bithynia (124 BC-40 BC) was a Greek physician who practiced and taught Greek medicine in Rome in the late second and early first century BC. His unique medical system was strongly influenced by Epicurean ... -
A Feasibility Study of Implantable Loop Recorder Monitoring Capacity in Older Fallers
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)INTRODUCTION: Falls are one of the most common causes of injury, prolonged hospitalisation, increased dependency and residential care admission amongst older people. There is a known association between cardiovascular ... -
The assessment, identification and management of Circadian rest-Activity Rhythm Disorders in patients with advanced Cancer (CARDiC)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)People with cancer may experience restless nights and be less physically active during the daytime. People with cancer may also find that the amount of time they spend being physically active or resting changes a lot between ... -
Seroprevalence, Molecular Epidemiology and Immunological Aspects of Human Herpesvirus 8 in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Human herpesvirus 8 (HHV-8) seroprevalence and molecular epidemiology vary both geographically and between sub-populations. Recent work has highlighted the importance of proinflammatory cytokines in the pathogenesis of ... -
The relationship of medications and hyperparathyroidism to bone mineral density in older adults
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Introduction and Aim Bone mineral density (BMD) is one of the strongest predictors of future fracture risk. As the population ages, understanding the effects of commonly prescribed medications on BMD is increasingly ... -
SARS-CoV-2 Hospital Epidemiology, Risks, Responses and Viral Dynamics Study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Background: Healthcare workers (HCW) are at increased risk for SARS-CoV-2 infection compared to the general community. The HERD study hypothesises that host, occupational and social factors influence this infection risk. ... -
Preventing Dementia: The Prevalence of Modifiable Risk Factors in People Attending Ireland's First Brain Health Clinic
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Cognition exists on a spectrum which ranges from normal cognition, subjective memory complaints (SMC), mild cognitive impairment (MCI) and dementia. Dementia prevalence is rising globally, driven largely by changing ... -
Molecular and clinical aspects of blood-brain barrier dysfunction in traumatic brain injury
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBI ranges from mild to severe, with concussion being considered a form of mild TBI (mTBI). Long-term issues, such as cognitive impairment ... -
Novel Non-Invasive Investigation of Spinal Cord Electrical Activity in Health and Neurodegeneration
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)The spinal cord (SC) extends from the lower end of the medulla oblongata to the lumbar region and is divided into five segments: cervical, thoracic, lumbar, sacral, and coccygeal. The spinal cord, as part of the central ... -
The Effects of Immunoregulatory Therapies on Human Macrophage Function and Metabolism: Implications for Mycobacterial Infections and Diseases
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Tuberculosis (TB), an endemic infecƟous disease caused by Mycobacterium tuberculosis (Mtb) is a huge burden globally. Dexamethasone is a potent long-acƟng syntheƟc glucocorƟcoid (GC) and presently, the role of GC as an ... -
An Investigation of the Effect of Pulsed Radiofrequency Treatment of the Dorsal Root Ganglion on Cerebrospinal fluid, peripheral venous blood and DRG washings in patients with chronic lumbosacral radicular pain
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, Department of Surgery, Trinity College Dublin, the University of Dublin, 2025)The objective of this thesis is to investigate alterations in the cellular and peptide composition of cerebrospinal fluid, blood, DRG washings and saliva in patients with a diagnosis of chronic lumbar radicular pain scheduled ... -
An Exploration of the Neurological Manifestations of Non-Cirrhotic Chronic Hepatitis C Infection in Ireland in the Direct-Acting Antiviral Era
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)An Exploration of the Neurological Manifestations of Non-Cirrhotic Chronic Hepatitis C Infection in Ireland in the Direct-Acting Antiviral Era. Ferguson, Damien. University of Dublin, Trinity College, School of Medicine. ... -
Reduced intensity conditioning with fludarabine, busulfan and anti-T lymphocyte globulin (FluBu3ATLG) for older patients with myeloid disease: determinants of outcome and the role of cytokine-based predictive modelling
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, School of Medicine, Trinity College Dublin, 2025)Fludarabine, busulfan and anti-T lymphocyte globulin (FluBu3ATLG) for reduced intensity conditioned (RIC) haematopoietic stem cell transplantation is an established regimen for older patients with myeloid disease. We ... -
Differential Pathogenic Mechanisms Driving Stromal Cell Inflammatory Pathways in RA and PsA
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Rheumatoid arthritis (RA) and Psoriatic arthritis (PsA) encompass two of the most prevalent forms of inflammatory arthritis (IA), an umbrella term for the vast range of autoimmune driven arthropathies characterised by ... -
The optimisation of a preselection methodology of heterotypic spheroids for the in vitro investigation of angiogenesis in lung cancer.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Lung cancer, particularly non-small cell lung cancer (NSCLC), is a leading cause of cancer-related deaths. Angiogenesis, the formation of new blood vessels, is essential for disease progression. The tumour microenvironment ... -
IFN-gamma-induced trained immunity as a strategy to enhance anti-microbial responses in human monocytes and macrophages.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Infectious diseases remain a significant global health threat, exacerbated by the rise in multi-drug- resistant infections and the potential for epidemics. Mycobacterium tuberculosis (M.tb) and Staphylococcus aureus are ... -
Investigating the effects of TLR2/MyD88 deficiency in mouse models of age-related macular degeneration
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Age-related macular degeneration (AMD) is the leading cause of blindness among older populations. Despite its global prevalence, a definitive cure for AMD remains elusive. To tackle this, we are focused on modulating the ... -
An Exploration of Cellular Signatures of Ageing, and the Effects of Age-Related Dysregulated Myeloid Circadian Rhythm in Retinal Disease.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Age-related macular degeneration (AMD) is the most common cause of vision loss and blindness in the elderly population across the developed world. This disease is characterised by a gradual degeneration and death of ... -
Hereditary Haemochromatosis: Hepatic and Cardiac Iron content and cardiac function at baseline and after a treatment course of venesection.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Background Hereditary haemochromatosis (HH) is the most common inherited genetic disorder in Europe1. Although there are several genetic mutations which can lead to the development of HH, the p.C282Y mutation (tyrosine ... -
The Role of Vascular Ultrasound in GCA-PMR Spectrum Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Background Timely and accurate identification of ‘GCA-PMR Spectrum Disease’ and its subsets is important so vascular complications can be averted. Traditional diagnostic and monitoring tools such as Temporal Artery ...
