RSS 1.0Clinical Medicine
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Clinical Medicine (Theses and Dissertations)
Recent Submissions
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Asclepiades of Bithynia's Medical Molecular Theory and his Contribution to Evolving Understandings of Mental Illness
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Asclepiades of Bithynia (124 BC-40 BC) was a Greek physician who practiced and taught Greek medicine in Rome in the late second and early first century BC. His unique medical system was strongly influenced by Epicurean ... -
A Feasibility Study of Implantable Loop Recorder Monitoring Capacity in Older Fallers
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)INTRODUCTION: Falls are one of the most common causes of injury, prolonged hospitalisation, increased dependency and residential care admission amongst older people. There is a known association between cardiovascular ... -
The assessment, identification and management of Circadian rest-Activity Rhythm Disorders in patients with advanced Cancer (CARDiC)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)People with cancer may experience restless nights and be less physically active during the daytime. People with cancer may also find that the amount of time they spend being physically active or resting changes a lot between ... -
Seroprevalence, Molecular Epidemiology and Immunological Aspects of Human Herpesvirus 8 in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Human herpesvirus 8 (HHV-8) seroprevalence and molecular epidemiology vary both geographically and between sub-populations. Recent work has highlighted the importance of proinflammatory cytokines in the pathogenesis of ... -
The relationship of medications and hyperparathyroidism to bone mineral density in older adults
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Introduction and Aim Bone mineral density (BMD) is one of the strongest predictors of future fracture risk. As the population ages, understanding the effects of commonly prescribed medications on BMD is increasingly ... -
SARS-CoV-2 Hospital Epidemiology, Risks, Responses and Viral Dynamics Study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Background: Healthcare workers (HCW) are at increased risk for SARS-CoV-2 infection compared to the general community. The HERD study hypothesises that host, occupational and social factors influence this infection risk. ... -
Preventing Dementia: The Prevalence of Modifiable Risk Factors in People Attending Ireland's First Brain Health Clinic
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Cognition exists on a spectrum which ranges from normal cognition, subjective memory complaints (SMC), mild cognitive impairment (MCI) and dementia. Dementia prevalence is rising globally, driven largely by changing ... -
Molecular and clinical aspects of blood-brain barrier dysfunction in traumatic brain injury
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBI ranges from mild to severe, with concussion being considered a form of mild TBI (mTBI). Long-term issues, such as cognitive impairment ... -
Novel Non-Invasive Investigation of Spinal Cord Electrical Activity in Health and Neurodegeneration
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)The spinal cord (SC) extends from the lower end of the medulla oblongata to the lumbar region and is divided into five segments: cervical, thoracic, lumbar, sacral, and coccygeal. The spinal cord, as part of the central ... -
The Effects of Immunoregulatory Therapies on Human Macrophage Function and Metabolism: Implications for Mycobacterial Infections and Diseases
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Tuberculosis (TB), an endemic infecƟous disease caused by Mycobacterium tuberculosis (Mtb) is a huge burden globally. Dexamethasone is a potent long-acƟng syntheƟc glucocorƟcoid (GC) and presently, the role of GC as an ... -
An Investigation of the Effect of Pulsed Radiofrequency Treatment of the Dorsal Root Ganglion on Cerebrospinal fluid, peripheral venous blood and DRG washings in patients with chronic lumbosacral radicular pain
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, Department of Surgery, Trinity College Dublin, the University of Dublin, 2025)The objective of this thesis is to investigate alterations in the cellular and peptide composition of cerebrospinal fluid, blood, DRG washings and saliva in patients with a diagnosis of chronic lumbar radicular pain scheduled ... -
An Exploration of the Neurological Manifestations of Non-Cirrhotic Chronic Hepatitis C Infection in Ireland in the Direct-Acting Antiviral Era
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)An Exploration of the Neurological Manifestations of Non-Cirrhotic Chronic Hepatitis C Infection in Ireland in the Direct-Acting Antiviral Era. Ferguson, Damien. University of Dublin, Trinity College, School of Medicine. ... -
Reduced intensity conditioning with fludarabine, busulfan and anti-T lymphocyte globulin (FluBu3ATLG) for older patients with myeloid disease: determinants of outcome and the role of cytokine-based predictive modelling
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, School of Medicine, Trinity College Dublin, 2025)Fludarabine, busulfan and anti-T lymphocyte globulin (FluBu3ATLG) for reduced intensity conditioned (RIC) haematopoietic stem cell transplantation is an established regimen for older patients with myeloid disease. We ... -
Differential Pathogenic Mechanisms Driving Stromal Cell Inflammatory Pathways in RA and PsA
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Rheumatoid arthritis (RA) and Psoriatic arthritis (PsA) encompass two of the most prevalent forms of inflammatory arthritis (IA), an umbrella term for the vast range of autoimmune driven arthropathies characterised by ... -
Allogeneic haematopoietic stem cell transplantation using reduced-intensity fludarabine, busulfan and anti-T lymphocyte globulin with strategic donor lymphocyte infusion in older patients with myeloid malignancy
(2025)Fludarabine, busulfan and anti-T lymphocyte globulin (FLUBU3+ATLG) reduced-intensity conditioning is an established preparative regimen for allogeneic haematopoietic stem cell transplantation in older patients with myeloid ... -
The optimisation of a preselection methodology of heterotypic spheroids for the in vitro investigation of angiogenesis in lung cancer.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Lung cancer, particularly non-small cell lung cancer (NSCLC), is a leading cause of cancer-related deaths. Angiogenesis, the formation of new blood vessels, is essential for disease progression. The tumour microenvironment ... -
Limitations of observational data in interpreting SPRINT results
(2018)We read with interest the Research Letter in a recent issue of JAMA Internal Medicine by Sexton et al 1 on the rates of syncope and injurious falls in Irish Longitudinal Study of Aging (TILDA) participants 75 years or ... -
Identifying key health system components associated with improved outcomes to inform the re-configuration of services for adults with rare autoimmune rheumatic diseases: a mixed-methods study
(2024)Background: Adults with rare autoimmune rheumatic diseases face unique challenges and struggles to navigate health-care systems designed to manage common conditions. Evidence to inform an optimal service framework for their ... -
Data driven subclassification of ANCA associated vasculitis: model-based clustering of the FAIRVASC cohort
(2024)Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a heterogenous autoimmune disease. While traditionally stratified into two conditions, granulomatosis with polyangiitis (GPA) and microscopic ...
