RSS 1.0Clinical Medicine (Scholarly Publications)
Recent Submissions
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Allogeneic haematopoietic stem cell transplantation using reduced-intensity fludarabine, busulfan and anti-T lymphocyte globulin with strategic donor lymphocyte infusion in older patients with myeloid malignancy
(2025)Fludarabine, busulfan and anti-T lymphocyte globulin (FLUBU3+ATLG) reduced-intensity conditioning is an established preparative regimen for allogeneic haematopoietic stem cell transplantation in older patients with myeloid ... -
Limitations of observational data in interpreting SPRINT results
(2018)We read with interest the Research Letter in a recent issue of JAMA Internal Medicine by Sexton et al 1 on the rates of syncope and injurious falls in Irish Longitudinal Study of Aging (TILDA) participants 75 years or ... -
Identifying key health system components associated with improved outcomes to inform the re-configuration of services for adults with rare autoimmune rheumatic diseases: a mixed-methods study
(2024)Background: Adults with rare autoimmune rheumatic diseases face unique challenges and struggles to navigate health-care systems designed to manage common conditions. Evidence to inform an optimal service framework for their ... -
Data driven subclassification of ANCA associated vasculitis: model-based clustering of the FAIRVASC cohort
(2024)Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a heterogenous autoimmune disease. While traditionally stratified into two conditions, granulomatosis with polyangiitis (GPA) and microscopic ... -
Ontology-based integration and querying of heterogeneous rare disease data sources - POLVAS perspective
(2025)The integration of rare disease medical databases belonging to different countries is an important problem, as a large number of observations are required for reliable statistical inference of patient data in order to ... -
Data quality and patient characteristics in European ANCA-associated vasculitis registries: data retrieval by federated querying
(2024)Objectives: This study aims to describe the data structure and harmonisation process, explore data quality and define characteristics, treatment, and outcomes of patients across six federated antineutrophil cytoplasmic ... -
Effect of Immunosuppression on the Immune Response to SARS-CoV-2 Infection and Vaccination.
(2024)Immunosuppressive treatment in patients with rheumatic diseases can maintain disease remission but also increase risk of infection. Their response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination ... -
Emergence of dysfunctional neutrophils with a defect in arginase-1 release in severe COVID-19
(2024)Neutrophilia occurs in patients infected with SARS-CoV-2 (COVID-19) and is predictive of poor outcomes. Here, we link heterogenous neutrophil populations to disease severity in COVID-19. We identified neutrophils with ... -
Type 2 innate lymphoid cells are not involved in mouse bladder tumor development
(2024)Therapies for bladder cancer patients are limited by side effects and failures, highlighting the need for novel targets to improve disease management. Given the emerging evidence highlighting the key role of innate ... -
Supportive care: the "keystone" of modern oncology practice
(2023)The Multinational Association of Supportive Care in Cancer (MASCC) defines supportive care as "the prevention and management of the adverse effects of cancer and its treatment. This includes management of physical and ... -
Taste disturbance in patients with advanced cancer: a scoping review of clinical features and complications
(2023)Purpose: The purpose of this scoping review is to appraise the published literature on taste disturbance in patients with advanced cancer, with the specific objectives being to determine its prevalence, clinical features ... -
Circadian rhythm disorders in patients with advanced cancer: a scoping review
(2023)Circadian rhythms can be demonstrated in several biomarkers and behavioural activities, with rhythmical patterns occurring roughly over a 24-h period. Circadian disorders occur in patients with cancer and may be associated ... -
Challenges to delivering evidence-based palliative medicine
(2023)Established as a medical specialty in 1987, palliative medicine approaches middle age facing existential questions of identity, purpose and vision. Time has weakened strong foundations laid by Dame Cicely Saunders in ... -
Xerostomia in patients with advanced cancer: a scoping review of clinical features and complications
(2023)Background: The aim of this project was to review the literature on dry mouth / xerostomia in patients with advanced cancer, with the objectives being to determine its prevalence, clinical features, and complications. Methods: ... -
Vital signs in palliative care: a scoping review
(2023)Vital signs are routinely measured in secondary healthcare settings and can be used to detect clinical problems, guide treatment, and monitor response to treatment. Vital signs are less frequently measured in palliative ... -
Validation of a French version of the Breakthrough Pain Assessment Tool in cancer patients: factorial structure, reliability and responsiveness
(2023)Objective: Breakthrough cancer pain should be properly assessed for better-personalized treatment plan. The Breakthrough Pain Assessment Tool is a 14-item tool validated in English developed for this purpose; no French ... -
International e-Delphi consensus recommendations for the assessment and diagnosis of circadian rest-activity rhythm disorders (CARDs) in patients with cancer
(2023)Purpose: Circadian rest-Activity Rhythm Disorders (CARDs) are common in patients with cancer, particularly in advanced disease. CARDs are associated with increased symptom burden, poorer quality of life, and shorter survival. ... -
Specialist palliative for patients with cancer: more than end-of-life care
(2023)Palliative care has traditionally focused on end-of-life care for patients with advanced cancer. This has since expanded to include symptom management and quality-of-life improvement from the moment of cancer diagnosis. ... -
Multinational Association of Supportive Care in Cancer (MASCC) expert opinion / guidance on the use of clinically-assisted hydration in patients with advanced cancer
(2024)Purpose: The provision of clinically assisted hydration (CAH) in patients with advanced cancer is controversial, and there is a paucity of specific guidance and so a diversity in clinical practice. Consequently, the ...
