Mechanical & Manufacturing Eng (Theses and Dissertations): Recent submissions
Now showing items 81-100 of 244
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The influence of scoliosis and wheechair customisations in rear impact
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)Considerable advances in wheelchair occupant frontal impact safety have been achieved, but further research in rear impact is required. Future analysis would benefit from more biofidelic representation of wheelchair ... -
Simulation of microcrack growth and repair in living bone
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)As they are the structural components of the body, bones are subjected to the accumulation of damage because of cyclical stress (fatigue). The fatigue damage in bone takes the form of microscopic cracks (microcracks) that ... -
The effect of mechanical cues on the chondrogenic differentiation of bone marrow derived mesenchymal stem cells
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2012)Tissue engineering strategies utilising mesenchymal stem cells (MSCs) represent a promising treatment option for a range of injuries and diseases. If MSCs are to be implanted in vivo, understanding the intricacies of how ... -
The characterisation of electrical energy consumption in complex manufacturing process chains
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)The combination of increasing energy costs, corporate image concerns, and environmental legislation is driving a transition towards energy and resource efficiency within the manufacturing sector. Developing a more comprehensive ... -
Heat transfer behaviour of a dilute impinging air-water mist jet
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2015)While the convective heat transfer characteristics of conventional air jets have received a large amount of attention, mist Jets remain relatively under-represented within the literature. The mist jet has the potential to ... -
Composite scaffold development and bioreactor culture for bone tissue engineering
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)Bone tissue engineering involves seeding bone cells onto a scaffold, culturing this construct so that mineralisation occurs (by using signalling mechanisms such as growth factors or bioreactors) and then implanting it into ... -
Mechanoregulated tissue organisation during skeletal repair : a computational study
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2012)Articular cartilage is a highly specialised bearing material that provides low friction, wear resistant contact between the ends of articulating bones in diarthrodial joints. In order to function in this mechanically ... -
Computational investigation into the mechanoregulation of osteoporosis
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)Trabecular bone remodelling involves the continual resorption and formation of bone along the surface of a strut. Experimental studies have shown that mechanical stimuli, such as strain and damage, initiate and regulate ... -
Analysis of the elastic and inelastic behaviour of healthy and diseased arterial tissue
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2012)Mechanical factors play a key role in determining the success of clinical procedures such as balloon angioplasty and stenting that aim to increase lumen size in atherosclerotic lesions. Finite element modelling is commonly ... -
Characterisation of an integrated telemetric temperature sensor for CFRP milling applications
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)The concept of a sensor designed to measure the behaviour of a machining process is a fundamental part of process monitoring and control. The perception of such a sensor is often underestimated when novel applications are ... -
An investigation of structure-function relations in articular cartilage during skeletal maturation
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)The over-riding objective of this thesis was to build upon our current understanding of the evolving nature of articular cartilage mechanics by elucidating how changes to structure and composition of the tissue during ... -
Experimental study of aeroacoustic noise production through combined flow measurements and array signal processing
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)The underlying processes behind sound generation in turbulent flows are still a source of debate. The investigation presented in this thesis focuses on the experimental approaches that aim to clarify this issue by estimating ... -
Stochastic failure modelling of total hip replacement
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)Failure of total hip replacement (THR) can be a highly variable phenomenon. Many factors of a different nature may affect the outcome of this operation, e.g. loads occuring in the joint, patient geometry, implant design, ... -
The evolution of an impinging synthetic air jet
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)Impinging synthetic jets are considered to offer great potential for many applications, including the thermal management of electronics. In this study, an experimental investigation into the evolution of an impinging ... -
Fundamental investigations into the micromilling of a biomedical grade polymer
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)The demand for polymer micromachining has been rapidly growing for a number of years in various diverse applications. Polymer components are generally produced by moulding; however, in some instances machining may be ... -
An investigation into the role of substrate stiffness and oxygen availability in the regulation of stem cell differentiation during tissue regeneration
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)Mesenchymal stem cells (MSCs) are multipotent cells which can differentiate down multiple lineages and potentially generate tissues such as cartilage, bone or adipose tissue. It is becoming increasingly clear that mechanical ... -
Deciphering the Molecular Mechanisms of Stem Cell Mechanotransduction: A New Avenue for the Development of Therapeutics for Osteoporosis
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Osteoporosis is characterised by reduced bone density and weakened bone architecture leading to high fracture risk. The changes in bone result from an imbalance in the bone remodelling cycle whereby the rate of resorption ... -
Hydrodynamics and heat transfer of laminar pulsating flow in a rectangular channel
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2017)The exploitation of flow pulsation is a potentially useful technique for enhanced cooling in single-phase cooling systems. This thesis contains parametric analyses of the hydrodynamics and heat transfer of a laminar ... -
The effect of stress concentrations on fatigue and fracture of 316L stainless steel micro-scale components
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004)The aim of this work was to investigate the fatigue and fracture behaviour of microscopic specimens based on a biomedical component (the cardiovascular stent) and to modify existing theories to take account of the observed ... -
Thermal aspects of the grinding process
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2000)Grinding is a commonly used process for material removal. It has been used for a long time mainly as a finishing process, although this situation is changing, with the development of creep feed grinding, and high efficiency ...
