Genetics (Theses and Dissertations): Recent submissions
Now showing items 161-180 of 218
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Exploration of novel therapeutics for autosomal dominant Retinitis Pigmentosa
(Trinity College (Dublin, Ireland). Department of Genetics, 2006)This thesis is concerned with exploration of a suppression and replacement therapeutic approach for the dominant form of Retinitis Pigmentosa (ADRP). Retinitis Pigmentosa is the most heterogeneous of all hereditary disorders ... -
Evolution of the genomes of two nematodes in the genus Caenorhabditis
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)The soil-dwelling nematode Caenorhabditis elegans has been intensively studied as a model organism for the last 40 years. It was the first animal for which we had a complete description of development, anatomy, a neural ... -
An investigation into the complex genetics of bipolar affective disorder : potential susceptibility loci and candidate genes from the Irish population
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Bipolar affective disorder (BPAD) is a serious and debilitating psychiatric illness characterised by extreme changes in mood, ranging from depression to mania. BPAD is undoubtedly caused by genetic factors, with some ... -
Post-polyploidy evolution in yeasts
(Trinity College (Dublin, Ireland). Department of Genetics, 2007)Whole-genome duplication (WGD) and gene duplication are topics central to the study of genome evolution. With the availability of genome sequences for both paleopolyploid (post-WGD) and non-polyploid outgroup (pre-WGD) ... -
Functional characterisation of Arabidopsis genes encoding members of the AP2/ERF transcription factor family
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)The EU Framework 5 REGIA (Regulatory Gene Initiative in Arabidopsis) Consortium, comprising 29 laboratories, was established to investigate transcription factor gene function in Arabidopsis. As part of the REGIA project, ... -
The essential YycFG two-component system controls cell wall metabolism in Bacillus subtilis
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)The work presented in this thesis describes a comprehensive analysis of the YycFG two-com ponent system (TCS) in Bacillus subtilis. TCSs are widespread mechanisms used by bacteria to sense and respond to the prevailing ... -
The monocyte protein C pathway : implications in human diseases
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)The protein C (PC) pathway provides an important link between the coagulation, fibrinolytic, and inflammatory pathways. PC/activated protein C (APC) is one o f very few therapies shown to effectively reduce the morbidity ... -
Exploration of RNAi-based therapeutic strategies for dominantly inherited disorders
(Trinity College (Dublin, Ireland). Department of Genetics, 2006)The primary aim of this thesis was to explore genetic agents with the ability to suppress expression of certain gene products i.e. those involved in the etiology of dominant disorders such as osteogenesis imperfecta (OI) ... -
Ancient Goat Genomics: Structure, Selection, and Admixture
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)The wild bezoar Capra aegagrus was brought under human control c. 8,000 BC, leading to the domestic goat Capra hircus. This livestock species remains in use 10,000 years later, and is of particular importance to communities ... -
Understanding the diverse roles of polycomb-like proteins in the regulation of chromatin and transcriptional landscapes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)The Polycomb repressive complex 2 (PRC2) is a multiprotein chromatin modifying complex that is essential for vertebrate development and frequently deregulated in cancer. In higher eukaryotes, PRC2 is responsible for all ... -
Blood-retina barrier regulation and sterile inflammation in retinal homeostasis and disease
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)Age-related macular degeneration (AMD) is the leading cause of central vision loss and blindness in the elderly. It is caused by a progressive loss of photoreceptors in the macula, thought to occur secondary to the damage ... -
Alternative routes to optimal expression levels: Evolutionary evidence for competitive RNAs and dosage compensation by gene duplication
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)Expression evolution and dosage constraints are important factors shaping genomic content and innovation. It has become increasingly clear that non-coding RNAs perform various regulatory functions in different cellular ... -
Comparative analysis of human and mouse acute phase Serum Amyloid A gene expression
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)The Serum Amyloid A (S AA) proteins are a family of highly conserved lipoproteins secreted by the liver. Their production and release is massively induced under conditions of inflammation or infection by pro-inflammatory ... -
Therapeutic approaches to halting photoreceptor cell death in the retina
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)Retinitis pigmentosa (RP) is a group of hereditary retinopathies affecting approximately 1 in 3500 people in the developed world. The disorders are characterised by the early onset of night blindness followed by a ... -
Novel therapeutic strategies for autosomal dominant retinitis pigmentosa
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)A major difficulty associated with the design of gene therapies for autosomal dominant diseases is the immense intragenic heterogeneity often encountered in such conditions. Two strategies which circumvent the difficulties ... -
A leaf-specific phage T7 RNA polymerase-based system for transgene expression in tobacco chloroplasts
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)This thesis describes the development of a chloroplast-localised gene expression system based on the phage T7 RNA polymerase. In order to direct T7 RNAP expression in a leaf-specific manner and to target it to the ... -
A bioinformatics approach to (intra-) genome comparisons
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2002)The analysis of large volumes of genomic data generates special computational needs. A Beowulf-type computer cluster was set up for high-performance computing. Improvements over existing tools for the efficient ... -
A novel gene-based therapy for galaucoma:from discovery to preclinical development
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Introduction: Glaucoma is a multifactorial condition that will often result in complete bilateral blindness if untreated. Elevated intraocular pressure (IOP) is both a major risk factor and indicator of disease. IOP is ... -
Complex evolutionary dynamics in simple genomes: the paradoxical survival of intracellular symbiotic bacteria
(Trinity College (Dublin, Ireland). Department of Genetics, 2009)Symbiosis is one of the ways in which nature has been able to generate biological innovation by fusing two organisms with different complexities. Because of these differing complexities, many problems for both organisms ... -
The genetics of Mycobacterium bovis infection in Irish cattle
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)Infection of livestock with Mycobacterium bovis, is the causing agent of bovine tuberculosis and is of major economic and health concern globally, with the cost of livestock loss estimated at €2 billion globally. In developed ...
