Genetics (Theses and Dissertations): Recent submissions
Now showing items 181-200 of 218
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Interpretation and improvement of the current genetic epidemiology methodology for schizophrenia
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Recent technological advancements have allowed for the development of new methodologies in the investigation of the genetic epidemiology of schizophrenia. Two of the most prominent methods in that field are the Polygenic ... -
Genetic analyses of thalamocortical axon guidance and subpallial development
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)Normal brain functioning in mammals depends on the establishment of specific, finely-organised neural networks connecting distant regions during development. In particular, sensory stimuli processing is supported by ... -
A new family of vertebrate-specific Polycombs encoded by the Lcor/Lcorl genes balance PRC2 subtype activities
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)The Polycomb Repressive Complex 2 (PRC2) is composed of the core subunits SUZ12, EED, RBBP4/7 and EZH1/2, which together are responsible for all di- and tri- methylation of lysine 27 on Histone H3 (H3K27me2/3). In addition, ... -
A Genomic Compendium of an Island: Documenting Continuity and Change across Irish Human Prehistory
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Abstract embargoed until 24/5/2023 -
The Multilayered Prehistory of Wild Aurochs and Domestic Cattle
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)This thesis explores 122 ancient genomes of domestic cattle and wild aurochs to investigate past population events such as domestication and admixture. Population genomics of ancient taurine domestics from the ancient Near ... -
The role of death receptors in ER stress and Inflamation
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Cell death induced in response to ER stress, particularly in response to classical ER stress-inducing agents thapsigargin, brefeldin A and tunicamycin, has been shown to be dependent on the ER stress-dependent upregulation ... -
Herding Ancient Domesticates: From Bones to Genomes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)This thesis demonstrates the power of the analysis of ancient domesticate genomes of cattle and sheep in order to analyse past population dynamics of the two species. In total 113 whole genomes and 127 mitogenomes of wild ... -
Analysis of stage-specific gene perturbations and characterisation of two novel F-box genes during flower development in Arabidopsis thaliana
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)The model plant Arabidopsis thaliana has been used for past three decades to study the genetic and molecular processes underlying floral organogenesis. Flowers of this small plant consist of four concentric whorls, containing ... -
Primary open-angle glaucoma: on the development of novel therapeutic approaches
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Glaucoma is one of the most prevalent forms of preventable blindness, affecting more than 60 million people worldwide. While normotensive forms of the disease do exist, the majority of cases are caused by elevations in ... -
Optimisation of therapies for inherited retinal and mitochondrial diseases
Inherited retinal degenerations (IRDs) are the most frequent cause of vision loss in people of working age. They have highly varied causes and pathophysiologies, and are typically incurable. Gene therapy has emerged as a ... -
The blood-brain barrier in neuropsychiatric disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Schizophrenia is a severe and disabling mental disorder that affects approximately 1% of the population. Such is the heterogeneous nature of the disease that genetic, neurobiological and environmental factors all contribute ... -
Targeting the tight-junctions of the conventional outflow pathway in primary open-angle glaucoma.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Primary open-angle glaucoma (POAG) is one of the leading causes of blindness worldwide, affecting an estimated 44.1 million people (Tham et al. 2014). POAG is characterised by elevated intraocular pressure (IOP) due to ... -
Investigation of the PhoPR two-component signal transduction system in Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Investigation of the PhoPR two-component signal transduction system in Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis. Michael Prunty The PhoPR two-component signal transduction system (TCS) ... -
Tight junctions of blood-brain barrier in Alzheimer's disease
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Located along the brain endothelium, the blood-brain barrier (BBB) is essential for regulating the exchange of ions and macromolecules between the blood circulation and neural tissue and restricting brain entry of potentially ... -
Inflammatory consequences of divergent cell death signals
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Tumor Necrosis Factor (TNF) is an apical cytokine that drives inflammation through triggering the synthesis and secretion of multiple downstream pro-inflammatory cytokines and chemokines. Generally, TNF stimulation does ... -
Persistent, ancient constraints shape copy number and expression variation of dosage-sensitive genes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2017) -
Control of floral meristem activity in the model plant Arabidopsis thaliana
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2017)Over the past 30 years, the flower development has been one of the main model to study the genetic control of organogenesis in higher plants. The work on Arabidopsis thaliana has led to the proposal of the ABC model of ... -
MicroRNA regulation of the bovine alveolar macrophage response to Mycobacterium bovis
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Bovine tuberculosis is one of the most economically significant infectious diseases of cattle in Ireland and globally, resulting in economic losses of approximately €2 billion annually. The causative agent is Mycobacterium ... -
Genetics of calving performance
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Calving performance is a significant contributor to the profitability of cattle production systems whilst also becoming an increasingly important welfare issue in recent years. Calving performance includes both dystocia ... -
Sterile inflammation and age-related macular degeneration
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Age-related macular degeneration (AMD) is the leading cause of legal blindness in elderly individuals in the developed world, estimated to affect 196 million people worldwide by 2020 (Wong et ai, 2014). AMD primarily affects ...
