Genetics (Scholarly Publications): Recent submissions
Now showing items 261-280 of 360
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Bacterial L-forms on tap: an improved methodology to generate Bacillus subtilis L-forms heralds a new era of research
(2012)Bacterial L-forms are cell wall-less forms of bacteria that usually grow with a conventional cell wall. Despite being important for research, L-forms are difficult to generate reproducibly and research in this area is ... -
Rethinking the genetic architecture of schizophrenia
(Cambridge University Press, 2011)Background. For many years, the prevailing paradigm has stated that in each individual with schizophrenia (SZ) the genetic risk is due to a combination of many genetic variants, individually of small effect. Recent empirical ... -
What Tyndall read: provenance, contents and significance of the Proby Bequest to Carlow Library
(CARLOW HISTORICAL AND ARCHAEOLOGICAL SOCIETY, 2011-11-30)We give a preliminary description of the provenance and contents of the library that the Tyndalls kept in Hind Head House, in Surrey, and the path it followed to end up in the Carlow County Council Library. For the provenance ... -
A letter from William B. Brownrigg to Thomas H. Huxley, dated 29 November 1865, authorising him to describe his fossil vertebrates from Jarrow Colliery, Co. Kilkenny and giving details of his find
(2011)William Bookey Brownrigg, who discovered the Upper Carboniferous (Pennsylvanian) vertebrate fossils at Jarrow Colliery, Co. Kilkenny in 1864, published a short paper on the material. Shortly afterwards E.P. Wright, a ... -
Following the genes: a framework for animal modeling of psychiatric disorders.
(2011)The number of individual cases of psychiatric disorders that can be ascribed to identified, rare, single mutations is increasing with great rapidity. Such mutations can be recapitulated in mice to generate animal models ... -
Parallel evolution of the make?accumulate?consume strategy in Saccharomyces and Dekkera yeasts
(Nature, 2011)Saccharomyces yeasts degrade sugars to two-carbon components, in particular ethanol, even in the presence of excess oxygen. This characteristic is called the Crabtree effect and is the background for the 'make?accumulate?consume' ... -
Treatment with a BH3 mimetic overcomes the resistance of latency III EBV (+) cells to p53-mediated apoptosis.
(Nature, 2011)P53 inactivation is often observed in Burkitt's lymphoma (BL) cells due to mutations in the p53 gene or overexpression of its negative regulator, murine double minute-2 (MDM2). This event is now considered an essential ... -
De Novo Origins of Human Genes
(2011)Where do new genes come from? For a long time the answer to that question has simply been ?from other genes?. The most prolific source of new loci in eukaryotic genomes is gene duplication in all its guises: exon shuffling, ... -
The uneasy correspondence between T. H. Huxley and E. P. Wright on fossil vertebrates found in Jarrow, Co. Kilkenny (1865-67)
(2011)The collection of Carboniferous fish and amphibian fossils found in Jarrow in 1864 has been the object of several studies, and has resided successively in at least three Irish museums. This paper draws from the Huxley ... -
The parallel lives of Joseph Allen Galbraith (1819-90) and Samuel Haughton (1821-97): religion, friendship, scholarship and politics in Victorian Ireland.
(Royal Irish Academy, 2012)Joseph Allen Galbraith and Samuel Haughton were both Junior Fellows at Trinity College Dublin, who in the 1840s became popular lecturers of mathematics-based subjects as well as successful textbook authors. In the 1880s ... -
Systematic discovery of unannotated genes in 11 yeast species using a database of orthologous genomic segments
(BioMed Central, 2011)Background: In standard BLAST searches, no information other than the sequences of the query and the database entries is considered. However, in situations where two genes from different species have only borderline ... -
Mechanisms of Chromosome Number Evolution in Yeast
(PLoS, 2011)The whole-genome duplication (WGD) that occurred during yeast evolution changed the basal number of chromosomes from 8 to 16. However, the number of chromosomes in post-WGD species now ranges between 10 and 16, and the ... -
Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90)
(2010)Retinitis pigmentosa (RP) is the most prevalent cause of registered visual handicap among working aged populations of developed countries. Up to 40% of autosomal dominant cases of disease are caused by mutations within the ... -
Caspase-1 promiscuity is counterbalanced by rapid inactivation of the processed enzyme.
(2011)Members of the caspase family of cysteine proteases coordinate the highly disparate processes of apoptosis and inflammation. However, while hundreds of substrates for the apoptosis effector caspases (caspase-3 and caspase-7) ... -
Ohnologs in the human genome are dosage balanced and frequently associated with disease
(2010)About 30% of protein-coding genes in the human genome are related through two whole genome duplication (WGD) events. Although WGD is often credited with great evolutionary importance, the processes governing the retention ... -
The complex relationship of gene duplication and essentiality.
(2009)In yeast and worm, duplicate genes overlap in function so that deleting one of a pair from the genome is less likely to be lethal than deleting a singleton gene. By contrast, previous analyses showed that mouse duplicate ... -
Evolutionary steps of sex chromosomes are reflected in retrogenes
(2008)It has been shown that selective pressure to compensate for the silencing of the sex chromosomes during male meiosis resulted in many X-linked genes being duplicated as functional retrogenes on autosomes. Sex chromosome ... -
Chromosomal G + C content evolution in yeasts: systematic interspecies differences, and GC-poor troughs at centromeres.
(2010)The G + C content at synonymous codon positions (GC3s) in genes varies along chromosomes in most eukaryotes. In Saccharomyces cerevisiae, regions of high GC3s are correlated with recombination hot spots, probably due to ... -
Structural Calibration of the Rates of Amino Acid Evolution in a Search for Darwin in Drifting Biological Systems.
(Oxford University Press, 2010)In the last two decades, many reports of proteins under positive selection have brought the neutral theory into question. However, the methods used to detect selection have ignored the evolvability of amino acids within ... -
Localized hypermutation and associated gene losses in legume chloroplast genomes
(2010)Point mutations result from errors made during DNA replication or repair, so they are usually expected to be homogeneous across all regions of a genome. However, we have found a region of chloroplast DNA in plants related ...
