Pharmacy and Pharmaceutical Sciences (Scholarly Publications): Recent submissions
Now showing items 381-400 of 452
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Danggui to Angelica sinensis root: Lost in translation? Are potential benefits of a TCM lost to European women? A review
(2014)AbstractEthnopharmacological relevance Danggui (Chinese Angelica root; Dong quai; Angelica sinensis (Oliv.) Diels.) is a traditional Chinese herbal remedy with a long history of use in China, Korea and Japan. Even today ... -
Synthesis and antiproliferative action of a novel series of maprotiline analogues
(2014)The synthesis of a diverse library of compounds structurally related to maprotiline, a norepinephrine reuptake transporter (NET) selective antidepressant which has recently been identified as a novel in vitro antiproliferative ... -
Collaborative pharmaceutical care in an Irish hospital: uncontrolled before-after study
(2014)Background We investigated the benefits of the Collaborative Pharmaceutical Care in Tallaght Hospital (PACT) service versus standard ward-based clinical pharmacy in adult inpatients receiving acute medical care, particularly ... -
Formation and physicochemical properties of crystalline and amorphous salts with different stoichiometries formed between ciprofloxacin and succinic acid
(2013)Multi-ionisable compounds, such as dicarboxylic acids, offer the possibility of forming salts of drugs with multiple stoichiometries. Attempts to crystallise ciprofloxacin, a poorly water soluble, amphoteric ... -
Troglitazone attenuates TGF-β1-induced EMT in alveolar epithelial cells via a PPARγ-independent mechanism
(2012)Peroxisome proliferator activated receptor ? (PPAR?) agonists are effective antifibrotic agents in a number of tissues. Effects of these agents on epithelial-mesenchymal transition (EMT) of primary alveolar epithelial cells ... -
Steroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery
(2013)In a number of pulmonary diseases, patients may develop abnormally viscous mucus reducing drug efficacy. To increase budesonide diffusion within lung fluid, we developed nanoporous microparticles (NPMPs) composed of ... -
The verapamil transporter in human alveolar epithelial cells (A549) does not interact with β2-receptor agonists
(2014)Affinity of different organs for verapamil is highly variable and organ-specific. For example, the drug exhibits high levels of accumulation in lung tissues. A transporter recognising verapamil as substrate has previously ... -
Tumour vasculature targeting agents in hybrid/conjugate drugs.
(2013)Tumour vasculature targeting has been a very active area of cancer drug discovery over the last decade. Growth of solid tumours beyond a certain point requires a sufficient blood supply in order for them to develop and ... -
Design template for a medication safety programme in an acute teaching hospital
(2012)Background: Very limited data have been published about the design of medication safety programmes in hospitals. Objective: To describe a template for the structure and operation of a medication safety programme in an ... -
Profiling harmful medication errors in an acute Irish teaching hospital.
(2012)Background: Medication error reporting systems in hospitals are faced with the challenge of processing vast numbers of reports which identify a myriad of safety issues. With such large volumes of data and limited resources ... -
Single oral dose study of two isosorbide-based aspirin prodrugs in the dog
(2003)The objective of this study was to compare two aspirin prodrugs, isosorbide diaspirinate (ISDA) and a nitroaspirin (ISMNA), with aspirin in terms of effects on dog platelet function after administration of a single oral ... -
A comparison of community pharmacy methadone services between Dublin and Glasgow: (1) Extent of service provision in 1997/8 and views of pharmacists on existing provision and future service developments.
(2004)Objectives: To determine the extent of pharmacists' participation in methadone services, type of services provided, views on current service provision and suggestions for future service developments. Methods and setting: ... -
N1-dansyl-spermine: a potent polyamine antagonist.
(2004)The potential polyamine antagonist action of N1-dansyl-spermine (a potent NMDA antagonist) was assessed in two in vivo mouse models of polyamine action. Co-administration of N1-dansyl-spermine (2?10 ?g, i.c.v.) with spermine ... -
Pharmacological effects of a novel isosorbide-based butyrylcholinesterase inhibitor
(2008)Isosorbide-2-benzylcarbamate-5-benzoate, a novel butyrylcholinesterase inhibitor, shows interspecies variation in its inhibitory activity (IC50 of 4.3 nM for human plasma butyrylcholinesterase, but 1.09 ?M for mouse plasma ...
