Pharmacy and Pharmaceutical Sciences (Scholarly Publications): Recent submissions
Now showing items 401-420 of 452
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Novel isosorbide di-ester compounds as inhibitors of acetylcholinesterase
(2008)We report herein that a variety of isosorbide di-esters, previously reported to be novel substrates for butyrylcholinesterase (BuChE, EC 3.1.1.8), are in fact inhibitors of the homologous enzyme acetylcholinesterase (AChE), ... -
Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability
(2010)Isosorbide-2-carbamate-5-esters are highly potent and selective butyrylcholinesterase inhibitors with potential utility in the treatment of Alzheimer?s Disease (AD). They are stable in human plasma but in mouse plasma they ... -
Measuring and benchmarking safety culture: application of the safety attitudes questionnaire to an acute medical admissions unit.
(2009)Objectives: To assess the safety culture in an acute medical admissions unit (AMAU) of a teaching hospital in order to benchmark results against international data and guide a unit-based, integrated, risk management ... -
The interrelation of Physicochemical Parameters and Topological Descriptors for a series of O-blocking Agents
(American Chemical Society, 2002)The intercorrelation between a series of physicochemical parameters and topological indices for a set of a-blockers is investigated. Partition coefficients are calculated using the ClogP program, and the results are compared ... -
Cytoskeletal re-arrangement in TGF-beta1-induced alveolar epithelial-mesenchymal transition studied by atomic force microscopy and high-content analysis
(2012)Epithelial-mesenchymal transition (EMT) is closely implicated in the pathogenesis of idiopathic pulmonary fibrosis. Associated with this phenotypic transition is acquisition of an elongated cell morphology and establishment ... -
Approaches to the safety assessment of engineered nanomaterials (ENM) in food
(Elsevier, 2011)A systematic, tiered approach to assess the safety of engineered nanomaterials (ENMs) in foods is presented. The ENM is first compared to its non-nano form counterpart to determine if ENM-specific assessment is required. ... -
In-vivo impact of prodrug isosorbide-5-nicotinate-2-aspirinate on lipids and prostaglandin D2: is this a new immediate-release therapeutic option for niacin?
(2012)Objectives: To evaluate the pharmacokinetics and effects of the first immediate-release (IR) niacin-aspirin prodrug (ST0702) on lipid, prostaglandin and thromboxane levels in non-human primates (NHPs). Methods: We ... -
The potential of metabolic fingerprinting as a tool for the modernisation of TCM preparations
(2012)A vast majority Chinese Herbal Medicines (CHM) are traditionally administered as individually prepared water decoctions (tang) which are rather complicated in practice and their dry extracts show technological problems ... -
Transport of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+) in human respiratory epithelial cells
(2012)Organic cation/carnitine transporters (OCT/N) mediate uptake of positively charged molecules. Their role in lung epithelium, however, is not well understood. OCT/N expression and activity was studied in cell lines of human ... -
Mechanisms of aggregation inhibition by aspirin and nitrate-aspirin prodrugs in human platelets
(2012)OBJECTIVES: Aspirin is the mainstay of anti-platelet therapy in the secondary prevention of cardiovascular disease. However, problems with aspirin safety and resistance demand clinical strategies based on multiple ... -
The PSD-95/nNOS Complex: New Drugs for Depression?
(2012)Drug treatment of major depressive disorder is currently limited to the use of agents which influence monoaminergic neuronal transmission including inhibitors of presynaptic transporters and monoamine oxidase. Typically ... -
A novel toxic alkaloid from poison hemlock (Conium maculatum L., Apiaceae): identification, synthesis and antinociceptive activity
(2012)2-Pentylpiperidine, named conmaculatin, a novel volatile alkaloid related to coniine was identified from the renowned toxic weed Conium maculatum L. (Apiaceae). The structure of conmaculatin was corroborated by synthesis ... -
Characterisation, solubility and intrinsic dissolution behaviour of benzamide:dibenzyl sulfoxide cocrystal
(2012)This study examined the 1:1 cocrystal benzamide:dibenzyl sulfoxide, comprising the poorly water soluble dibenzyl sulfoxide (DBSO) and the more soluble benzamide (BA), to establish if this cocrystal shows advantages in terms ... -
Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells inflammatory and cytotoxicity effects.
(2011)BACKGROUND: The purpose of this study was to investigate the mechanism of noxious effects of amorphous silica nanoparticles on human endothelial cells. METHODS: Nanoparticle uptake was examined by transmission electron ... -
Characterisation and manipulation of docetaxel resistant prostate cancer cell lines
(2011)Background: There is no effective treatment strategy for advanced castration-resistant prostate cancer. Although Docetaxel (Taxotere?) represents the most active chemotherapeutic agent it only gives a modest survival ... -
Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis
(2010)Background: Malignant melanoma, generally described as incurable, is notoriously refractory to chemotherapy. The mechanisms contributing to this have not yet been defined and the contributions of drug efflux pumps, ... -
Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation
(2011)The present study investigated the effect of operating parameters of a laboratory spray dryer on powder characteristics, in order to optimise the production of trehalose and raffinose powders, intended to be used as carriers ... -
Investigating the effect of solubility and density gradients on local hydrodynamics and drug dissolution in the USP 4 dissolution apparatus
(2011)The aim of this investigation was to evaluate the effect of solubility and related solution density gradients, on hydrodynamics and dissolution rate in a low velocity pulsing flow, in the USP 4 flow-through dissolution ... -
N-subsituted homopiperazine barbiturates as gelatinase inhibitors
(2011)Matrix metalloproteinases are implicated in a wide range of pathophysiological processes and potent selective inhibitors for these enzymes continue to be eagerly sought. 5,5-Disubstituted barbiturates hold promise as ... -
Engineering of therapeutic proteins production in Escherichia coli
(Bentham, 2011)Low cost and simplicity of cultivating bacteria make the E. coli expression system a preferable choice for production of therapeutic proteins both on a lab scale and in industry. In addition straightforward recombinant DNA ...
