Pharmacy and Pharmaceutical Sciences (Scholarly Publications): Recent submissions
Now showing items 421-440 of 452
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An evaluation of ciprofloxacin pharmacokinetics in critically ill patients undergoing continuous veno-venous haemodiafiltration.
(PLoS, 2011)BACKGROUND: The study aimed to investigate the pharmacokinetics of intravenous ciprofloxacin and the adequacy of 400 mg every 12 hours in critically ill Intensive Care Unit (ICU) patients on continuous veno-venous ... -
Solid state characterisation of novel active pharmaceutical ingredients: co-crystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt
(Wiley, 2011)The production of salt or cocrystalline forms is a common approach to alter the physicochemical properties of pharmaceutical compounds. The goal of this work was to evaluate the impact of anion choice (succinate, adipate, ... -
Polystyrene nanoparticles activate ion transport in human airway epithelial cells
(2011)Background: Over the last decade, nanotechnology has provided researchers with new nanometer materials, such as nanoparticles, which have the potential to provide new therapies for many lung diseases. In this study, we ... -
Gene expression analysis of mouse embryonic stem cells following levitation in an ultrasound standing wave trap.
(2011)In the present paper, gene expression analysis of mouse embryonic stem (ES) cells levitated in a novel ultrasound standing wave trap (USWT) (Bazou et al. 2005a) at variable acoustic pressures (0.08?0.85 MPa) and times ... -
The DUMP Campaign
(green cross publishing, 2009-05)From an initial group of six pharmacies in 2002, now every pharmacy in the area is a part of the DUMP initiative, which urges consumers to `Dispose of Unused Medication Properly? and attempts to achieve this by ... -
Identification of a new antinociceptive alkaloid isopropyl N-methylanthranilate from the essential oil of Choisya ternata Kunth
(2011)Ethnopharmacological relevance: Mexican people employed infusion of leaves of Choisya ternata Kunth for their antispasmodic and ?simulative properties? Aim of the study: In the present study the detailed GC and GC-MS ... -
In vivo assessment of parenteral formulations of oligo(3-hydroxybutyric acid) conjugates with the model compound ibuprofen
(2010)Polymer-drug conjugates have gained significant attention as pro-drugs releasing an active substance as a result of enzymatic hydrolysis in physiological environment. In this study, a conjugate of 3-hydroxybutyric acid ... -
Effects of a nanocomposite containing Orbignya speciosa lipophilic extract on Benign Prostatic Hyperplasia
(2011)Aim of the study : Lower urinary tract symptoms (LUTS) are a common complaint among aging men and are usually caused by Benign Prostatic Hyperplasia (BPH). A number of medical treatments for LUTS/BPH exist, such as ... -
Synthesis, evaluation and structural studies of antiproliferative tubulin-targeting azetidin-2-ones
(2011)A series of azetidin-2-ones substituted at positions 2, 3 and 4 of the azetidinone ring scaffold were synthesised and evaluated for antiproliferative, cytotoxic and tubulin binding activity. In these compounds, the cis ... -
Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds
(Elsevier, 2011)In a continuation of our studies into indan and tetralin systems as novel modulators of allergic and inflammatory phenomena, we have extended our work to include dimers linked via C-C bonds. Of these compounds, ... -
Nanoparticles attenuate P-glycoprotein/MDR1 function in A549 human alveolar epithelial cells
(2011)P-glycoprotein/MDR1 (P-gp) is a well characterised membrane transporter relevant in drug disposition and multi-drug resistance. In this study, we aimed to investigate in how far nanoparticulates impair the function of the ... -
Synthesis and pharmacological evaluation of the individual stereoisomers of 3- [methyl(1,2,3,4-tetrahydro-2-naphthalenyl)amino]-1-indanone, a potent mast cell stabilising agent
(Elsevier, 2011)Each stereoisomer of 3-[methyl(1,2,3,4-tetrahydro-2-naphthalenyl)amino]-1-indanone, 1a-d, was prepared and evaluated in vitro for its ability to prevent mediator release induced by different degranulating agents from rodent ... -
Particle engineering of materials for oral inhalation by dry powder inhalers. II - Sodium cromoglicate
(2011)Sodium cromoglicate is an antiasthmatic and antiallergenic drug used in inhalation therapy and commonly administered by a dry powder inhaler. In the present study we sought to examine the feasibility of producing nanoporous ... -
Particle engineering of materials for oral inhalation by dry powder inhalers. I - Particles of sugar excipients (trehalose and raffinose) for protein delivery
(2011)The pulmonary route of delivery offers a potential alternative to parenteral administration of peptides and proteins. Protection of protein structure is essential in both processing and storage of the final formulation. ... -
Preparation and characterisation of novel chlorothiazide potassium solid-state salt forms: intermolecular self assembly suprastructures
(Elsevier, 2011)Chlorothiazide (CTZ) is a poorly soluble diuretic agent. The aim of the present work was to produce and characterise a potassium salt form of chlorothiazide which has the potential advantages of improved aqueous solubility ... -
Preparation and solid state characterisation of chlorothiazide sodium intermolecular self assembly suprastructure
(Elsevier, 2010)Chlorothiazide (CTZ), unlike other thiazide diuretics, can form salts. An injectable formulation containing the sodium salt is available; however neither the physicochemical characteristics of the salt nor its solid state ... -
The particle has landed - characterizing the fate of inhaled pharmaceuticals
(2010)Although there is a modest body of literature on the absorption of inhaled pharmaceuticals by normal lungs and some limited information from diseased lungs, there is still a surprising lack of mechanistic knowledge about ... -
A role for adenosine A1 receptor blockade in the ability of caffeine to promote MDMA "Ecstasy"-induced striatal dopamine release
(2011)Co-administration of caffeine profoundly enhances the acute toxicity of 3,4 methylenedioxymethamphetamine (MDMA) in rats. The aim of this study was to determine the ability of caffeine to impact upon MDMA-induced dopamine ... -
Development and characterisation of soluble polymeric particles for pulmonary peptide delivery
(2010)Pulmonary administration of protein and peptide drugs using inhaled dry powder particles is an interesting alternative to parenteral delivery. The stabilisation of these molecules is essential to the maintenance of biological ... -
Stability of salmon calcitonin against trypsin, chymotrypsin and neutrophil elastase in human lung epithelial cells
(2010)At least three enzymes (i. e., trypsin, chymotrypsin and neutrophil elastase) are responsible for the degradation of salmon calcitonin (sCT) in the human body. Here, we investigated how these proteinases affect drug ...
