School of Genetics & Microbiology: Recent submissions
Now showing items 21-40 of 911
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A history of multiple Denisovan introgression events in modern humans
(2024)The identification of a new hominin group in the Altai mountains called Denisovans was one of the most exciting discoveries in human evolution in the last decade. Unlike Neanderthal remains, the Denisovan fossil record ... -
Population genetics of Ancient Western Europe
(Trinity College (Dublin, Ireland). Department of Genetics, 2017)The field of Ancient DNA has been the subject of significant progress during the last decade, shifting from the analysis of a few hundred basepairs to whole-genome data. The main advantage of ancient DNA is the direct ... -
Control of floral meristem activity in the model plant Arabidopsis thaliana
(Trinity College (Dublin, Ireland). Department of Genetics, 2017)Over the past 30 years, the flower development has been one of the main model to study the genetic control of organogenesis in higher plants. The work on Arahidopsis thaliana has led to the proposal of the ABC model of ... -
Genomic and transcriptomic profiling of Coeliac Disease
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)Coeliac Disease (CD) is a chronic immune mediated disease triggered by the ingestion of gluten. It has an estimated prevalence of approximately 1% in European populations. Genome-wide association studies (GWAS) have ... -
Neutrophil-derived proteases act as global regulators of IL-1 family cytokine activation states
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)IL-1 family cytokines are pleiotropic cytokines capable of eliciting robust proinflammatory cytokine and chemokine secretion from a broad variety of cell types and tissues. Recent evidence has strongly implicated IL-36 ... -
Investigating the contributions to cell function of the different Swi-Snf complex subunits in Saccharomyces cerevisiae
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)The eukaryotic genome is packaged as a DNA-protein structure known as chromatin. The basic subunit of chromatin is the nucleosome, which contains two copies of each of the core histone proteins H2A, H2B, H3, and H4, around ... -
Investigating a role for linker histone H1 in quiescent cells of Saccharomyces cerevisiae
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)The aim of this study was to determine whether either Hho1p or Hmo1p can be considered the best candidate to function as linker histone H1 in Saccharomyces cerevisiae. The hypothesis was that yeast linker histone H1 would ... -
Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection
(2024)Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and must be tightly regulated to avoid ... -
The ophthalmic manifestations of neurological disease
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)The retina is responsible for visual processing by converting light signals into nerve impulses. It comprises both the central retina, termed the macula, and the peripheral retina. There are several subtypes of peripheral ... -
Characterisation of the floral transcriptome of Sinapis alba and analysis of PRC2 accessory proteins in Arabidopsis thaliana
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Flower development has been studied in the model organism Arabidopsis thaliana for decades. Years of research into the development of the floral organs - carpels, stamens, petals and sepals - led to the formation of the ... -
Investigating the recruitment, interactions, and activity of Polycomb proteins in development and disease.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Polycomb group proteins are chromatin regulators associated with transcriptional repression of developmentally important genes. They assemble into multiprotein complexes, including Polycomb Repressive Complex 1 (PRC1) and ... -
Investigating the roles of the floral-associated genes TRIPTYCHON, SHATTERPROOF and AGAMOUS in Arabidopsis thaliana and Brassica rapa
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)The genetic mechanisms responsible for flower development has been studied for over four decades now in Arabidopsis thaliana, a model organism for plants. However, more recently, plant research has become increasingly ... -
RNP Granules and Neurodegeneration: Molecular Strategies to Regulate Condensation and Aggregation
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Eukaryotic cell organisation is classically described in terms of a cytoplasm and discrete, membrane-bound organelles enclosed within a plasma membrane. However, more recently it has been recognised that cells also organise ... -
Secondary messenger signalling influences Pseudomonas aeruginosa adaptation to sinus and lung environments
(2024)Pseudomonas aeruginosa is a cause of chronic respiratory tract infections in people with cystic fibrosis (CF), non-CF bronchiectasis, and chronic obstructive pulmonary disease. Prolonged infection allows the accumulation ... -
The role of non-coding regulatory elements and PRC2 proteins in disease and development
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Nucleosomes are the basic repeating units of chromatin. Not only do they provide a way to package the DNA into a tight nucleus, but they also contribute to the regulation of our genome. Composed of histone proteins, ... -
Understanding Tolerance to Biocides and its Consequences in Clinical Isolates of Klebsiella pneumoniae - How to Treat an ESKAPE Pathogen
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)Biocides such as Triclosan, Benzalkonium Chloride, and Chlorhexidine have been used as disinfectants for many years, however the effects of their use and the subsequent selective pressures applied to microbial populations ... -
The transcriptional landscape and small RNAs in Acinetobacter baumannii AB5075 during antibiotic and environmental stress.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)Multi-drug resistant Acinetobacter baumannii is considered a major challenge because it causes a variety of serious infections. Studying these bacteria at the level of their genetic response could facilitate finding a way ... -
Understanding benzalkonium chloride tolerance and its implications in antibiotic resistance and other phenotypes in clinical isolates of Klebsiella pneumoniae
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)In this study, clinical isolates of Klebsiella pneumoniae, a Gram-negative pathogen associated with hospital acquired infections, were tested for both phenotypic and genotypic changes following adaptation to the commonly ... -
Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement
(2022)Interleukin-1 (IL-1) family cytokines are key barrier cytokines that are typically expressed as inactive, or partially active, precursors that require proteolysis within their amino termini for activation. IL-37 is an ... -
Ancient Genomics and Human Health
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Studies of ancient DNA over the last decade have been pivotal in answering archaeological, evolutionary and ecological questions. More recently, this data has also been used in the analysis of human health in the past, in ...
