School of Genetics & Microbiology: Recent submissions
Now showing items 281-300 of 911
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Molecular genetic typing characteristics of human and animal isolates of Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2009)Staphylococcus aureus is a commensal and an opportunistic pathogen of both man and animals. It is capable of causing a broad spectrum of diseases, ranging in severity from superficial skin complaints such as boils and ... -
Investigating regulation of gene transcription by the Tup1-Ssn6 co-repressor complex in Saccharomyces cerevisiae
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)Transcriptional repression is an important part of gene regulation. In the budding yeast Saccharomyces cerevisiae the Tup1-Ssn6 corepressof complex is recruited to gene promoters to repress transcription in response to ... -
Fibronectin-binding protein B (FnBPB) from Staphylococcus aureus protects against the antimicrobial activity of histones
(2019)Staphylococcus aureus is a Gram-positive bacterium that can cause both superficial and deep-seated infections. Histones released by neutrophils kill bacteria by binding to the bacterial cell surface and causing membrane ... -
Protein coadaptation and the design of novel approaches to identify protein-protein interactions
(2011)Proteins rarely function in isolation but they form part of complex networks of interactions with other proteins within or among cells. The importance of a particular protein for cell viability is directly dependent upon ... -
Investigation of the molecular mechanisms of functional innovation
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)The robustness to perturbations and evolvability of genomes are two major principles that govern the emergence of genetic diversity across all forms of life. Functional innovations that occur through the genetic diversity ... -
The role of granzyme B and other granule proteases as modulators of cytokine activity
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)Excerpt from introduction: In all vertebrate organisms a properly functioning immune system is absolutely required for protection against infectious agents and also acts as a safeguard against tumour development. Over time ... -
Genetic mechanisms establishing thalamocortical connectivity : novel genes and a role for Semaphorin6B
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)One of the main functions of the brain is to process information from the environment. All input to the neocortex passes through the thalamus in order to be handled. Therefore, proper connectivity between the thalamus and ... -
ITap, a novel irhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
(eLife Sciences Publications, 2018)The apical inflammatory cytokine TNF regulates numerous important biological processes including inflammation and cell death, and drives inflammatory diseases. TNF secretion requires TACE (also called ADAM17), which cleaves ... -
To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps
(Springer Nature, 2019)Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics andphysiological functions of NETs have been uncovered. Nowadays, thefield continues to expand and novel ... -
How to prepare and deliver a great talk
(2019)Giving a talk can be daunting, particularly for scientists at the very early stages of their careers. Standing in front of an audience and speaking for 20–30 minutes do is never easy, and even those who do it for a ... -
The role of π?π stacking and hydrogen-bonding interactions in the assembly of a series of isostructural group iib coordination compounds
(2019)The supramolecular chemistry of coordination compounds has become an important research domain of modern inorganic chemistry. Herein, six isostructural group IIB coordination compounds containing a 2-{[(2-methoxyphe ... -
Molecular Engineering of Free-Base Porphyrins as Ligands-The N-H? ? ? X Binding Motif in Tetrapyrroles
(2019)The core N-H units of planar porphyrins are often inaccessible to forming hydrogen-bonding complexes with acceptor molecules. This is due to the fact that the amine moieties are “shielded” by the macrocyclic system, ... -
Nonconjugated Hydrocarbons as Rigid-Linear Motifs: Isosteres for Material Sciences and Bioorganic and Medicinal Chemistry
(2018)Nonconjugated hydrocarbons, like bicyclo[1.1.1]pentane, bicyclo[2.2.2]octane, triptycene, and cubane are a unique class of rigid linkers. Due to their similarity in size and shape they are useful mimics of classic benzene ... -
Claudin-5: Gatekeeper of neurological function
(2019)Tight junction proteins of the blood–brain barrier are vital for maintaining integrity of endothelial cells lining brain blood vessels. The presence of these protein complexes in the space between endothelial cells creates ... -
Discovery and engineering of antimicrobial peptides to combat food spoilage
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)This work sought to use a bioinformatics based approach to discover plant derived antimicrobial peptides which were structurally similar to human β-defensin 3 (HBD3) and which possessed effective antimicrobial activity ... -
FNR is a regulator of Salmonella pathogenicity Island 2 in Salmonella Typhimurium
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)During infection, S. Typhimurium employs Salmonella pathogenicity island (SPI)-encoded type three secretion systems (T3SS) 1 and 2 to invade and survive in host cells. However, expression of SPI-2 is seen at the epithelial ... -
Variance components for bovine tuberculosis infection and multi-breed genome-wide association analysis using imputed whole genome sequence data
(2019)Bovine tuberculosis (bTB) is an infectious disease of cattle generally caused by Mycobacterium bovis, a bacterium that can elicit disease humans. Since the 1950s, the objective of the national bTB eradication program in ... -
DNA supercoiling and transcription: a two-way street
(2019)Background : The processes of DNA supercoiling and transcription are interdependent because the movement of a transcription elongation complex simultaneously induces under- and over winding of the DNA duplex and because ... -
Investigating factors that contribute to the ability of Staphylococcus aureus to colonise atopic dermatitis skin
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)The skin of atopic dermatitis (AD) patients is frequently colonised by Staphylococcus aureus. Colonisation by S. aureus correlates with disease severity and exacerbated disease symptoms. The factors involved in S. aureus ... -
A novel anti-viral role for STAT3 in IFN-α signalling responses.
(Springer, 2017-05)The cytokine, Interferon (IFN)-α, induces a wide spectrum of anti-viral mediators, via the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. STAT1 and STAT2 are well characterised ...
