School of Genetics & Microbiology: Recent submissions
Now showing items 301-320 of 911
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A molecular genetic investigation of Irish origins
(Trinity College (Dublin, Ireland). Department of Genetics, 2000)Three hundred and ninety-four male DNA samples, from Ireland, Turkey and Togo, were genotyped for 5 X chromosome simple tandem repeat (STR) loci. Six Y chromosome STR loci and 8 Y chromosome unique event polymorphisms were ... -
Testing the hypothesis of genome duplications in vertebrates
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)The hypothesis that the human genome has undergone at least two rounds of genome duplication has become widely accepted, but has never been rigorously tested. In this study, several map-based inter- and intra-species ... -
Gene order evolution and genomic analyses of the model eukaryote, Saccharomyces cerevisiae, and other yeast species
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)The complete genome sequence of the yeast Saccharomyces cerevisiae can be used to form a clearer picture of the evolution of the diverse species of yeast and to construct a model of eukaryote genome evolution. In this study ... -
Family-based molecular genetic studies in bipolar affective disorder
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)This thesis covers gene mapping experiments applied to bipolar affective disorder (BPD), a severe recurrent psychiatric condition with a lifetime prevalence of 1-2%, and a substantial familial component. The study sample ... -
Genome sequencing and functional genomics in Bacillus subtilis : the expression and roles of the superoxide dismutases and NADH dehydrogenases
(Trinity College (Dublin, Ireland). Department of Genetics, 2002)The work in this thesis spans genome sequencing of Bacillus subtilis, functional analysis of genes of unknown function and more detailed characterisation of the function and regulation of specific genes. Approximately 0.7% ... -
Trypanotolerace in West African cattle and the population genetic effects of selection
(Trinity College (Dublin, Ireland). Department of Genetics, 2002)A panel of 69 microsatellite loci was used to investigate the population genetic effects of selection at genes on linked, neutral markers. Loci were typed in African and European Bos taurus cattle and Bos indicus populations ... -
Analysis of the role of human papillomaviruses and the p53/Rb tumour suppressor genes in the development of cutaneous squamous cell carcinoma
(Trinity College (Dublin, Ireland). Department of Microbiology, 2000)Nonmelanoma skin cancers (NMSC) are the most frequent cancers in Caucasian populations. Renal transplant recipients (RTR) are at an increased risk of neoplasia, particularly skin cancer. Studies on anogenital cancer have ... -
Molecular and quantative analyses of genetic variation in farmed Atlantic salmon
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)Genetic diversity between three farmed and four wild populations and within six 6 year classes of one farmed population of Atlantic salmon were analysed using 15 microsatellite markers. High levels of polymorphism were ... -
A study of the expression and roles of Bacillus subtilis HtrA-type serine proteases
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)Upon sequencing a region of the Bacillus subtilis genome assigned to the author of this thesis, an open reading frame encoding a homologue of an HtrA-type serine protease, YkdA, was identified. The HtrA serine protease ... -
Investigations on apoptosis-associated caspase activation cascades
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)Apoptosis is an important process in a wide variety of different biological systems such as the immune system, normal cell turnover and embryonic development (Stennicke et al., 2002). Apoptosis is characterized by a series ... -
Identification and characterisation of an FK506-binding protein from Plasmodium falciparum
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)Malaria remains one of the most significant diseases worldwide. The most common and severe form of the disease is caused by Plasmodium falciparum. The need for new anti-malarial compounds has intensified in recent years ... -
Gene therapy strategies for dominant heterogeneous disorders and the identification of a novel gene causing retinitis pigmentosa and sensorineural deafness
(Trinity College (Dublin, Ireland). Department of Genetics, 2000)The purpose of this Ph.D. thesis has been to contribute towards the generation of therapies for inherited disorders such as retinitis pigmentosa (RP) and osteogenesis imperfecta (OI). In chapter 2, a novel mitochondrial ... -
On the development of animal models for degenerative retinal disease
(Trinity College (Dublin, Ireland). Department of Genetics, 2000)Retinitis pigmentosa (RP) is one of the leading causes of inherited blindness within the working population of many developed countries. There is presently no cure for this disorder. The projects outlined in this thesis ... -
Recombinant vaccines against infectious pancreatic necrosis virus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2000)The rapid expansion of the aquaculture industry in recent years has led to an increase in disease outbreaks. Over the last few years bacterial disease problems have been brought under control, largely due to the use of a ... -
Variations in silver stained nucleolar organiser regions(AgNORs) in normal, irradiated and neoplastic tissues
(Trinity College (Dublin, Ireland). Department of Microbiology, 2001)Nucleolar organiser regions (NORs) are loops of ribosomal DNA which contain the genes that transcribe to ribosomal RNA. They are situated on the short arm of the acrocentric human chromosomes 13, 14, 15, 21 and 22. Several ... -
Molecular genetic investigations of the diversity and origins of Old and New World cattle population
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)One hundred and forty-nine Bos indicus mitochondrial DNA (mtDNA) control region sequences sampled from the Indian subcontinent, the Near East and East Asia were assessed in order to investigate the domestic origins and ... -
On the molecular genetics of bipolar affective disorder
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)This thesis describes genome-wide gene mapping analyses as applied to bipolar affective disorder (BPAD). This condition is a severe recurrent psychiatric disorder, with a substantial familial component and an estimated ... -
On the molecular genetics of retinal dystrophies and glaucoma
(Trinity College (Dublin, Ireland). Department of Genetics, 2000)The central aim of this thesis was the elucidation of the underlying molecular pathologies of inherited diseases of the eye. Previous linkage studies on a large Spanish kindred (family FA-84), segregating adRP, resulted ... -
On the molecular genetics of bipolar disorder
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)A modified genome scan, concentrating primarily on gene rich regions of the genome was employed by this group to search for regions harboring susceptibility loci for bipolar disorder in a panel of 48 Irish sib-pair families ... -
Helicobacter pylori infection : in vitro diagnostic methods, antimicrobial susceptibility testing, epidemiology of recrudescence and clarithromycin resistance
(Trinity College (Dublin, Ireland). Department of Microbiology, 2000)H. pylori is a Gram-negative, non-spore forming, curved bacterium that colonises the gastric epithelium of the human stomach. H. pylori is firmly established as an aetiological agent in peptic ulcer disease and successful ...
