Browsing Immunology by Title
Now showing items 1-20 of 54
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A numerical, phenotypical and functional characterization of innate T cell populations in CVID
(Trinity College (Dublin, Ireland). Department of Immunology, 2016)Common Variable Immunodeficiency (CVID) is a primary antibody deficiency characterized by widespread B cell defects, low serum immunoglobulin levels, recurrent infections and frequent idiopathic complications, including ... -
Altered distributions and functions of natural killer T cells and γδ T cells in neonates with neonatal encephalopathy, in school-age children at follow-up, and in children with cerebral palsy
(2021)We enumerated conventional and innate lymphocyte populations in neonates with neonatal encephalopathy (NE), school-age children post-NE, children with cerebral palsy and age-matched controls. Using flow cytometry, we ... -
Altered endotoxin responsiveness in healthy children with Down syndrome.
(2018)Background: Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we examined ... -
Analysis of the autoantibody response directed against tissue transglutaminase in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2006)Coeliac disease is an inflammatory disease of the proximal small intestine caused by wheat gluten ingestion in genetically susceptible individuals. The mucosal pathology in coeliac disease is characterised by villous ... -
CD1d expression and invariant natural killer T-cell numbers are reduced in patients with upper gastrointestinal cancers and are further impaired by commonly used chemotherapies
(2020)Esophageal and gastric cancers collectively cause over 1.1 million deaths annually and only 20-30% of patients respond favorably to current therapies. Cellular therapies using invariant natural killer T (iNKT) cells are ... -
Characterisation of gut mucosa in patients with potential coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2007)Coeliac disease is a gluten dependent enteropathy with a high incidence and increased risk of mortality. Diagnosis of coeliac disease is based on a biopsy of small intestine. However, it is now believed that many individuals ... -
Characterisation of mouse strains with spontaneous mutations, leading to epidermal barrier dysfunction and inflammation
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Atopic dermatitis is a chronic pruritic skin disease, associated with eczematous lesions, epidermal barrier dysfunction, and Immunoglobulin-E-mediated sensitization to food and environmental allergens. The complex ... -
Characterising Cytokine Gene Expression Signatures in Patients with Severe Sepsis
(2013)Introduction. Severe sepsis in humans may be related to an underlying profound immune suppressive state. We investigated the link between gene expression of immune regulatory cytokines and the range of illness severity in ... -
Defiency of natural killer receptor expressing cells in haemophagocytic lymphohistiocytosis
(Trinity College (Dublin, Ireland). Department of Immunology, 2002)Two children, patient A and patient B, were diagnosed on clinical and histological grounds to have haemophagocytic lymphohistiocytosis (HLH) (Henter et al. 1991a; Arico et al. 2001a). Clinical presentation of HLH consists ... -
Design, optimisation and functional relevance of in silico tools for the study of coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2008)Peptide-MHC interaction is a crucial pre-requisite for the recognition of antigen by T cells. It has long been recognised that peptides with a high affinity for MHC molecules are more likely to elicit a pronounced T cell ... -
Distinct and Overlapping Effector Functions of Expanded Human CD4, CD8? and CD4CD8? Invariant Natural Killer T Cells
(2011)CD1d-restricted invariant natural killer T (iNKT) cells have diverse immune stimulatory/regulatory activities through their ability to release cytokines and to kill or transactivate other cells. Activation of iNKT cells ... -
Distinct hepatic myeloid and lymphoid cell repertoires are associated with susceptibility and resistance to Ascaris infection
(2021)The soil-transmitted helminth Ascaris lumbricoides infects ~800 million people worldwide. Some people are heavily infected, harbouring many worms, whereas others are only lightly infected. The mechanisms behind this ... -
Effect of nutritional status and nutritional supplementation on clinical, nutritional and immunological outcomes among HIV infected adults in Uganda
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2019) -
Epigenetic targeting of CD1d increases cytolytic activity of invariant natural killer T cells against non-small cell lung cancer cells
(Trinity College (Dublin, Ireland). Department of Immunology, 2016)Lung cancer is the most common form of cancer-related death in the world, accounting for approximately 19.4% of all cancer mortalities. Currently platinum-based therapies are the gold-standard of care for non-small cell ... -
Evolutionary origins and functions of Schistosoma mansoni Pellino
(Trinity College (Dublin, Ireland). Department of Immunology, 2012)The immune system of modern man has innate signalling pathways that arose in ancestral species. This is exemplified by the discovery of the Toll-like receptor (TLR) pathway using free-living model organisms, specifically ... -
Examining the role of lymphocytes in health and in neonatal encephalopathy and the influence of mucosal associated T cells on B cell functions
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2022)Background. Neonatal encephalopathy (NE) is a neurological syndrome in term babies characterised by altered levels of consciousness, seizures, abnormal tone and reflexes, and/or failure to initiate or maintain respiration. ... -
Functional studies on human γδ T cells and their interactions with dendritic cells and B cells
(Trinity College (Dublin, Ireland). Department of Immunology, 2016)γδ T cells are innate T cells that play central roles in protection against microorganisms and cellular stress. There are three main subsets in humans: Vδ1, Vδ2 and Vδ3 T cells. The most abundant of these, Vδ2 T cells, ... -
Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis.
(Springer, 2011)AIMS/HYPOTHESIS: The innate immune cells, invariant natural killer T cells (iNKT cells), are implicated in the pathogenesis of psoriasis, an inflammatory condition associated with obesity and other metabolic diseases, ...
