Browsing Haematology by Date of Publication
Now showing items 1-20 of 39
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Genetic analysis of the human prohibitin gene (PHB) in breast and other cancers
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2000)Prohibitin, an evolutionarily conserved gene situated on chromosome 17q21, was originally identified as a gene with antiproliferative properties. Studies of a Japanese population have shown prohibitin to be somatically ... -
The protein C pathway : linking inflammation and coagulation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2000)Activated protein C (APC) is a natural anticoagulant and plays a pivotal role in coagulation homeostasis by inhibiting factors Villa and Va. Recent data suggests that APC also negatively regulates pro-inflammatory cytokine ... -
Isolation and characterisation of a monocyte protein C receptor : implications for novel therapeutic strategies in sepsis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2003)The protein C (PC) pathway provides a unique interface between the processes of coagulation, inflammation and fibrinolysis. Used as an adjunct to standard treatment, PC/activated PC to date, has been shown to be the only ... -
The coagulation & inflammation interface : the pathophysiological basis for disease states
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2003)The molecular and cellular pathways of coagulation and inflammation have traditionally been regarded as separate entities, however recent research has demonstrated that they are closely linked through endothelial and ... -
Cellular and molecular mechanisms associated with sensitivity to DNA damaging agents in various human genetic disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2005)The integrity of the genome is important to cellular and organism homeostasis. It is under constant threat due to intrinsic and extrinsic factors which contribute to a variety of genetic alterations and so genomic integrity ... -
An investigation into the potential use of Beta-Galactoside binding protein as a novel anti-leukaemic agent
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2005)Chronic myelogenous leukaemia (CML) is characterised at the molecular level by a (9;22) translocation which places the abl proto-oncogene under the control of the breakpoint cluster region (bcr) gene promoter generating a ... -
Multifunctional specificity of the protein C/activated protein C Gla domain.
(American Society for Biochemistry and Molecular Biology, 2006)Activated protein C (APC) has potent anticoagulant and anti-inflammatory properties that are mediated in part by its interactions with its cofactor protein S and the endothelial cell protein C receptor (EPCR). The protein ... -
Defining inherited haematological disease within the Irish traveller population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2006)The Traveller Community in Ireland constitutes a minority of nomadic or semi-nomadic people, sharing a common Irish ancestry. The Traveller Health Study showed that in 1987, Travellers were only reaching the life expectancy ... -
ADAMTS13 substrate recognition of von Willebrand factor A2 domain.
(2006)ADAMTS13 controls the multimeric size of circulating von Willebrand factor (VWF) by cleaving the Tyr1605?Met1606 bond in theA2 domain. To examine substrate recognition, we expressed in bacteria and purified three A2 ... -
Prostate cancer progression to androgen independence - do changes in the androgen receptor CAG repeat number play a role?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2007)Prostate cancer is the commonest non-cutaneous male malignancy and is the second commonest cause of cancer-related deaths in many Western countries. Approximately half of all men diagnosed with prostate cancer will have ... -
A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin.
(2008)The ordered, directional migration of T-lymphocytes is a key process during immune surveillance, immune response, and development. A novel series of pyrrolo-1,5-benzoxazepines have been shown to potently induce apoptosis ... -
Drug-induced veno-occlusive disease of the liver : unravelling the role of the inflammatory and coagulation pathways
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2008)The thiopurines thioguanine (6TG) and mercaptopurine (6MP), along with Mylotarg (an antibody targeted agent), are used in the treatment of acute leukaemias. These drugs are more commonly associated with the development of ... -
Prognostic factors in chronic lymphocytic leukemia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2008)Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world, accounting for nearly 24% of all leukaemias. It is estimated that 7300 new cases were diagnosed in 2003 in the United States and there ... -
Detection of minimal residual disease and WT1 overexpression in childhood acute leukaemia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2008)Minimal residual disease (MRD), the post-treatment presence of a small submicroscopic amount of leukaemic cells in the bone marrow or other sites undetectable by conventional methods, has been recently shown to be one of ... -
Dissociation of activated protein C functions by elimination of protein S cofactor enhancement.
(2008)Activated protein C (APC) plays a critical anticoagulant role in vivo by inactivating procoagulant factor Va and factor VIIIa and thus down-regulating thrombin generation. In addition, APC bound to the endothelial cell ... -
Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition.
(2009)Plasmodium falciparum infection results in adhesion of infected erythrocytes to blood vessel endothelium, and acute endothelial cell activation, together with sequestration of platelets and leucocytes. We have previously ... -
Investigations into Pyrrolo-1,5-Benzoxazepine-15-induced apoptosis of chronic B-cell malignancies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2009)Multiple myeloma and chronic lymphocytic leukaemia (CLL) are chronic B-cell malignancies, which are characterised by the accumulation of malignant cells with low proliferative capacity and defective apoptotic mechanisms. ... -
Platelet factor 4 impairs the anticoagulant activity of activated protein C.
(2009)Platelet factor 4 (PF4) is an abundant platelet -granule chemokine released following platelet activation. PF4 interacts with thrombomodulin and the -carboxyglutamic acid (Gla) domain of protein C, thereby enhancing ... -
Variation in DNA repair genes XRCC3, XRCC4, and XRCC5 and susceptibility ot myeloma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2010)Cytogenetic analysis in myeloma reveals marked chromosomal instability. Both widespread genomic alterations and evidence of aberrant class switch recombination, the physiological process that regulates maturation of the ... -
Modulation of activated protein C (APC) anticoagulant and cytoprotective function
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2011)Activated protein C (APC) is an anticoagulant glycoprotein that attenuates thrombin generation. Moreover, it has recently been demonstrated that APC possesses anti-inflammatory, anti-apoptotic and endothelial cell barrier ...
